Biochemistry, Biophysics, and Structural Biology Commons^™

The Maintenance Of Genomic Stability: Impacts Of The Loss Of Kif18a, Leslie Anne Sepaniac

Graduate College Dissertations and Theses

Regulated and repeated cell division is necessary for the development, growth, and reproduction of multicellular organisms. A central purpose of mitosis is to faithfully pass hereditary information from one cell onto two genetically identical daughter cells, thus maintaining genomic stability. Cells employ several mechanisms for maintaining genomic stability, including well-characterized cell cycle checkpoints. However, chromosome segregation errors can occur in spite of these regulatory mechanisms. Such errors can result in an improper number of chromosomes being distributed to daughter cells – termed aneuploidy – or improper localization of chromosomes into separate satellite nuclei – termed micronuclei. What, if any, additional …