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Biochemistry, Biophysics, and Structural Biology Commons™
Open Access. Powered by Scholars. Published by Universities.®
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- Library research in the Geosciences (3)
- Collection development (2)
- Environmental information resources (2)
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- DNA (1)
- DNA methylation (1)
- Endocytosis (1)
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- Flavobacterium columnare, columnaris disease, chondroitin AC lyase, complementation, csl operon (1)
- GTPases (1)
- Gene expression (1)
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Articles 1 - 15 of 15
Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Upregulation Of The Predominant Cystic Fibrosis Causing Mutation Df508-Cftr By Triazole Compounds In Epithelial Cells, Maggie Taylor
Upregulation Of The Predominant Cystic Fibrosis Causing Mutation Df508-Cftr By Triazole Compounds In Epithelial Cells, Maggie Taylor
Undergraduate Research Conference
Cystic fibrosis is a common genetic disease that is caused by a mutation in the plasma membrane protein CFTR, which stands for Cystic Fibrosis Transmembrane-conductance Regulator. When this membrane protein is mutated, it impairs its chloride ion channel function, blocking the movement of chloride ions that travel in and out of the cell. Previous studies have demonstrated that the most prevalent CFTR mutation, ∆F508-CFTR, can be partially reversed using small molecules (Heda and Marino, BBRC, 271:659-664, 2000). In this study, I have investigated the effects of several triazole compounds known to bind and transport chloride ions in cultured cells, on …
Two And Three-Dimensional Radiographic Imaging Of Contrast Agents In Heterogeneous Live Cell Media To Understand Contrast-Induced Toxicity, Fahaneda Hassan, Aldona Gjoni, Subhendra Sarkar
Two And Three-Dimensional Radiographic Imaging Of Contrast Agents In Heterogeneous Live Cell Media To Understand Contrast-Induced Toxicity, Fahaneda Hassan, Aldona Gjoni, Subhendra Sarkar
Publications and Research
Radiographic imaging was done using low and high energy radiography equipment. The test hypothesis that macromolecular aggregation changes sample noise in imaging samples for optical imaging methods. Inorganic complexes scatter radiation at the molecular level and may increase the sample noise locally. At high and low photon energies in various x-ray machines, sample and background noise were gathered and compared with those from mammography systems from mammography researchers. The samples with high macromolecular aggregates were prepared using various animal cell compositions and imaged under different conditions that produced different macromolecular dynamics within the samples and thus different image-based sample noise. …
A Crispr Platform For Rapid And Inducible Genome Editing In Human Non-Small Cell Lung Cancer Cells, Lloyd Bartley
A Crispr Platform For Rapid And Inducible Genome Editing In Human Non-Small Cell Lung Cancer Cells, Lloyd Bartley
Posters-at-the-Capitol
Non-small cell lung cancer (NSCLC) accounts for about 85% of lung cancer, which is the leading cause of cancer death in the world. High mortality rate associated with NSCLC is partially attributed to the limited understanding of NSCLC as well as ineffective therapeutic treatments. The initiation and progression of NSCLC involves genetic changes leading to alterations in the control of tissue development and homeostatic maintenance. Better knowledge about these genetic abnormalities is imperative for developing new chemotherapeutic drugs for NSCLC. Recent research demonstrates that the expression of paraoxonase 2 (PON2), a lactonase/arylesterase with anti-oxidant properties, are markedly enhanced in cancer …
Development Of A Pd-L1 Pet Imaging Biomarker, Caleb Jack Bridgwater
Development Of A Pd-L1 Pet Imaging Biomarker, Caleb Jack Bridgwater
Posters-at-the-Capitol
Immunotherapy strategies are very promising treatments for cancer patients. Specifically, Immune checkpoint inhibitor therapy focusing on the PD-1/PD-L1 pathway shows long-lasting positive results in many cancer patients. Unfortunately, not all the patients can benefit from this highly effective treatment. Hence, there is a great need for predictive biomarkers. Immunohistochemical (IHC) staining has been used as a way of predicting patient response, yet shows many problems. For example, IHC utilizes an invasive biopsy and sample fixing, which creates an incomplete and delayed picture of the patient’s biochemistry and the tumor microenvironment, consequently ignoring metastases.
The purpose of this study is to …
Applied Drug Development And Combinatorial Strategies For Antimicrobial Treatment, Steven K. Lai Hing
Applied Drug Development And Combinatorial Strategies For Antimicrobial Treatment, Steven K. Lai Hing
Andrews Research Conference
Streptococcus mutans JH1140 is a strain of bacteria which produces a lantibiotic product, named mutacin 1140. Mutacin 1140 has been shown to be effective at inhibiting Gram-positive bacterial infections caused by Staphylococcus aureus and Streptococcus pneumoniae. Mutacin 1140 is a ribosomally synthesized peptide antibiotic that undergoes extensive posttranslational modifications (PTM). We have found that Mutacin 1140 and an aminoglycoside, Kanamycin, when combined together, act synergistically against Staphylococcus aureus. This was determined by performing serial kill curve dilution overlays on solid media, followed up with kill curve by microdilution plate, and most recently confirmed with kill curve CFU count plates …
Epigenetic Regulation Of Gene Expression During Spermatogenesis, Karishma Nayak
Epigenetic Regulation Of Gene Expression During Spermatogenesis, Karishma Nayak
Senior Honors Projects
In the US livestock production industry, improving reproductive efficiency will improve animal welfare and maintain reasonable costs of meat and milk for consumers. In recent research, abnormalities in epigenetic markers in sperm during spermatogenesis, has been linked to male subfertility in many species. Epigenetics is the study of changes in organisms caused by modifications of gene expression, including DNA methylation, rather than alteration of the genetic code itself. When this process is disturbed, it can negatively impact semen therefore decreasing its fertility. Through further research on how DNA methylation influences gene expression during spermatogenesis and its impact on sperm quality, …
Requirements Of Rab5 Activity In Highly Invasive Breast Cancer Cell Lines, Nicole Porther, M Alejandro Barbieri
Requirements Of Rab5 Activity In Highly Invasive Breast Cancer Cell Lines, Nicole Porther, M Alejandro Barbieri
Nicole Porther
Analysis Of The Chondroitinase Operon Of Flavobacterium Columnare, Erin L. Sorlien
Analysis Of The Chondroitinase Operon Of Flavobacterium Columnare, Erin L. Sorlien
Senior Honors Projects
Analysis of the chondroitinase operon of Flavobacterium columnare
Erin Sorlien
Major
Cell and Molecular Biology, Chemistry
Advisor
Dr. David R. Nelson
Date
May 2, 2013
Keywords
Flavobacterium columnare, columnaris disease, chondroitin AC lyase, complementation, csl operon
Abstract
Flavobacterium columnare, an opportunistic bacterial pathogen of fish, is the causative agent of columnaris disease (CD). The bacterium is a Gram-negative rod that exhibits gliding motility and avidly forms biofilms. CD affects both wild and cultured freshwater fish, and continues to cause large economic losses to the fish farming industry. According to an investigation conducted by the National Animal Health Monitoring System, CD …
Rab5 Function In Breast Cancer Cells, Nicole Porther, M Alejandro Barbieri
Rab5 Function In Breast Cancer Cells, Nicole Porther, M Alejandro Barbieri
Nicole Porther
Libraries At The University Of Massachusetts Amherst: Seeking An International Perspective, Maxine G. Schmidt
Libraries At The University Of Massachusetts Amherst: Seeking An International Perspective, Maxine G. Schmidt
Maxine G Schmidt
Presentation delivered to librarians in China, Japan and South Korea as part of my sabbatical research on the use of libraries by Asian students in their home countries.
Arcane Secrets Of The Umass Libraries, Maxine G. Schmidt
Arcane Secrets Of The Umass Libraries, Maxine G. Schmidt
Maxine G Schmidt
No abstract provided.
An Entrepreneurial Approach To Librarianship, Flora G. Shrode, Jennifer R. Duncan, Wendy Holliday
An Entrepreneurial Approach To Librarianship, Flora G. Shrode, Jennifer R. Duncan, Wendy Holliday
Flora Shrode
Librarians from Utah State University explain recent efforts to encourage subject librarians to take a more holistic view of their roles. We are shifting from a traditional emphasis primarily on collection development and refocusing on natural connections between collections, instruction, liaison, and reference service. The poster provides background about Utah State University’s situation and explains our approach to analyzing local needs and culture to inform development of a new organizational structure. We describe our vision of subject librarianship, the process by which we assessed librarians’ ideas and goals for performing as subject librarians, and the actions we are taking to …
An Entrepreneurial Approach To Librarianship, Flora Shrode, Jennifer Duncan, Wendy Holliday
An Entrepreneurial Approach To Librarianship, Flora Shrode, Jennifer Duncan, Wendy Holliday
Library Faculty & Staff Publications
Librarians from Utah State University explain recent efforts to encourage subject librarians to take a more holistic view of their roles. We are shifting from a traditional emphasis primarily on collection development and refocusing on natural connections between collections, instruction, liaison, and reference service. The poster provides background about Utah State University’s situation and explains our approach to analyzing local needs and culture to inform development of a new organizational structure. We describe our vision of subject librarianship, the process by which we assessed librarians’ ideas and goals for performing as subject librarians, and the actions we are taking to …
Umass Libraries 2009, Maxine G. Schmidt
Important, But Odd And Obscure, Reasons To Use The Library, Maxine G. Schmidt
Important, But Odd And Obscure, Reasons To Use The Library, Maxine G. Schmidt
Maxine G Schmidt
No abstract provided.