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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Parallel Quorum-Sensing System In Vibrio Cholerae Prevents Signal Interference Inside The Host., Samit Watve, Kelsey Barrasso, Sarah A Jung, Kristen J Davis, Lisa A Hawver, Atul Khataokar, Ryan G Palaganas, Matthew B Neiditch, Lark Perez, Wai-Leung Ng
Parallel Quorum-Sensing System In Vibrio Cholerae Prevents Signal Interference Inside The Host., Samit Watve, Kelsey Barrasso, Sarah A Jung, Kristen J Davis, Lisa A Hawver, Atul Khataokar, Ryan G Palaganas, Matthew B Neiditch, Lark Perez, Wai-Leung Ng
College of Science & Mathematics Departmental Research
Many bacteria use quorum sensing (QS) to regulate virulence factor production in response to changes in population density. QS is mediated through the production, secretion, and detection of signaling molecules called autoinducers (AIs) to modulate population-wide behavioral changes. Four histidine kinases, LuxPQ, CqsS, CqsR and VpsS, have been identified in Vibrio cholerae as QS receptors to activate virulence gene expression at low cell density. Detection of AIs by these receptors leads to virulence gene repression at high cell density. The redundancy among these receptors is puzzling since any one of the four receptors is sufficient to support colonization of V. …
Plant Lectin Can Target Receptors Containing Sialic Acid, Exemplified By Podoplanin, To Inhibit Transformed Cell Growth And Migration, Jhon Ochoa-Alvarez, Harini Krishnan, Yongquan Shen, Nimish Acharya, Min Han, Dean Mcnulty, Hitoki Hasegawa
Plant Lectin Can Target Receptors Containing Sialic Acid, Exemplified By Podoplanin, To Inhibit Transformed Cell Growth And Migration, Jhon Ochoa-Alvarez, Harini Krishnan, Yongquan Shen, Nimish Acharya, Min Han, Dean Mcnulty, Hitoki Hasegawa
Rowan-Virtua School of Osteopathic Medicine Departmental Research
Cancer is a leading cause of death of men and women worldwide. Tumor cell motility contributes to metastatic invasion that causes the vast majority of cancer deaths. Extracellular receptors modified by α2,3-sialic acids that promote this motility can serve as ideal chemotherapeutic targets. For example, the extracellular domain of the mucin receptor podoplanin (PDPN) is highly O-glycosylated with α2,3-sialic acid linked to galactose. PDPN is activated by endogenous ligands to induce tumor cell motility and metastasis. Dietary lectins that target proteins containing α2,3-sialic acid inhibit tumor cell growth. However, anti-cancer lectins that have been examined thus far target receptors …