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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Fetal Cocaine Exposure Causes Epigenetic Changes In The Rat Heart, Kurt D. Meyer
Fetal Cocaine Exposure Causes Epigenetic Changes In The Rat Heart, Kurt D. Meyer
Loma Linda University Electronic Theses, Dissertations & Projects
Cocaine abuse continues to be prevalent in the United States and other industrialized nations, in addition to the negative health effects that cocaine abuse has on the user, a mother who uses cocaine while pregnant also exposes the developing fetus to cocaine. Although there have been many studies of the effects of cocaine on the adult heart, studies of cocaine on the fetal heart and its potential delayed pathophysiological effects on cardiac function in adult offspring are extremely limited. The studies of the present project sought to enhance the understanding of the effect of cocaine exposure on the fetal heart …
Localization And Expression Of The Aer Receptor In Escherichia Coli, Daniel Salcedo
Localization And Expression Of The Aer Receptor In Escherichia Coli, Daniel Salcedo
Loma Linda University Electronic Theses, Dissertations & Projects
In Escherichia coli, chemotactic movement towards an energetically-favorable environment is mediated by five transmembrane chemoreceptors. These sensory proteins respond to numerous environmental signals, including amino acids, sugars, and pH. The aerotaxis receptor, Aer, is an intracellular sensor that responds to oxygen concentration and other parameters affecting cellular energy levels. Bacterial chemotaxis receptors form dimeric signaling units that organize into tetramers and hexamers and form large clusters at the cell poles. A cluster arrangement could increase receptor sensitivity by lateral communication between dimers, thus amplifying the signal from one dimer. We have shown that Aer forms dimers, trimer of dimers, …