Animal Sciences Commons^™

A Computational Psychiatry Approach Identifies How Alpha-2a Noradrenergic Agonist Guanfacine Affects Feature-Based Reinforcement Learning In The Macaque, S. A. Hassani, M. Oemisch, M. Balcarras, S. Westendorff, S Ardid, M. A. Van Der Meer, P. Tiesinga, T. Womelsdorf

Dartmouth Scholarship

Noradrenaline is believed to support cognitive flexibility through the alpha 2A noradrenergic receptor (a2A-NAR) acting in prefrontal cortex. Enhanced flexibility has been inferred from improved working memory with the a2A-NA agonist Guanfacine. But it has been unclear whether Guanfacine improves specific attention and learning mechanisms beyond working memory, and whether the drug effects can be formalized computationally to allow single subject predictions. We tested and confirmed these suggestions in a case study with a healthy nonhuman primate performing a feature-based reversal learning task evaluating performance using Bayesian and Reinforcement learning models. In an initial dose-testing phase we found a Guanfacine …