Animal Sciences Commons^™

Livestock Animals To Study Infertility In Women, Mohamed A. Abedal-Majed, Andrea S. Cupp

Department of Animal Science: Faculty Publications

• Anovulation is a major cause of infertility in mammalian females.

• Ovarian research in humans is challenging due to the shortage of “normal tissue” that can be obtained from women that are trying to get pregnant.

• Livestock animals provide valuable resources to investigate the optimal intra-follicular environment required to facilitate folliculogenesis and translate to humans.

• Different livestock models may be more useful depending on the specific biological process studied.

Perturbations In Lineage Specification Of Granulosa And Theca Cells May Alter Corpus Luteum Formation And Function, Mohamed A. Abedel-Majed, Sarah M. Romereim, John S. Davis, Andrea S. Cupp

Department of Animal Science: Faculty Publications

Anovulation is a major cause of infertility, and it is the major leading reproductive disorder in mammalian females. Without ovulation, an oocyte is not released from the ovarian follicle to be fertilized and a corpus luteum is not formed. The corpus luteum formed from the luteinized somatic follicular cells following ovulation, vasculature cells, and immune cells is critical for progesterone production and maintenance of pregnancy. Follicular theca cells differentiate into small luteal cells (SLCs) that produce progesterone in response to luteinizing hormone (LH), and granulosa cells luteinize to become large luteal cells (LLCs) that have a high rate of basal …