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Defining A Haplotype Encompassing The Lcorl-Ncapg Locus Associated With Increased Lean Growth In Beef Cattle, Leif E. Majeres
Defining A Haplotype Encompassing The Lcorl-Ncapg Locus Associated With Increased Lean Growth In Beef Cattle, Leif E. Majeres
Masters Theses
Numerous studies have shown genetic variation at the LCORL-NCAPG locus is strongly associated with growth traits in beef cattle. However, a causative molecular variant has yet to be identified. To define all possible candidate variants, 34 Charolais-sired calves were whole genome sequenced including 17 homozygous for a long-range haplotype associated with increased growth (QQ), and 17 homozygous for potential ancestral haplotypes for this region (qq). The Q haplotype was refined to an 814-kb region between chr6:37,199,897-38,014,080 and contained 218 variants not found in qq individuals. These variants include an insertion in an intron of NCAPG, …