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Prokinetic And Laxative Effects Of The Crude Methanolic Extract Of Viola Betonicifolia Whole Plant In Rodents, Naveed Muhammad, Najeeb Rehman,, Haroon Khan, Muhammad Saeed, Anwar Gilani
Prokinetic And Laxative Effects Of The Crude Methanolic Extract Of Viola Betonicifolia Whole Plant In Rodents, Naveed Muhammad, Najeeb Rehman,, Haroon Khan, Muhammad Saeed, Anwar Gilani
Department of Biological & Biomedical Sciences
Abstract Background: The present study was aimed to provide ethnopharmacological basis for the medicinal use of Viola betonicifolia whole plant in indigestion and constipation. Methods: Mice were used in in-vivo prokinetic and laxative studies while in-vitro experiments were conducted on isolated tissues of rabbit and guinea-pig gut preparations suspended in a tissue bath to measure isotonic contractions. Results: The crude methanolic extract of Viola betonicifolia (VBME) showed partially atropine-sensitive prokinetic (50 and 100 mg/kg) and laxative (30 and 100 mg/kg) activities in mice. When tested in isolated rabbit jejunum and guinea-pig ileum, VBME caused dose-dependent contractions at 0.01-0.3 mg/mL and …