Life Sciences Commons^™

Harnessing Exosomes As A Platform For Drug Delivery In Breast Cancer: A Systematic Review For In Vivo And In Vitro Studies, Abdulwahab Teflischi Gharavi, Saeed Irian, Azadeh Niknejad, Keykavous Parang, Mona Salimi

Pharmacy Faculty Articles and Research

Breast cancer remains a significant global health concern, emphasizing the critical need for effective treatment strategies, especially targeted therapies. This systematic review summarizes the findings from in vitro and in vivo studies regarding the therapeutic potential of exosomes as drug delivery platforms in the field of breast cancer treatment. A comprehensive search was conducted across bibliographic datasets, including Web of Science, PubMed, and Scopus, using relevant queries from several related published articles and the Medical Subject Headings Database. Then, all morphological, biomechanical, histopathological, and cellular-molecular outcomes were systematically collected. A total of 30 studies were identified based on the Preferred …

Effectiveness Of Intervention Studies Based On Diet And/Or Physical Activity In Treatment, Prevention, And Management Of Diabetes Among South Asians: A Systematic Review, Ishaan Arora

Theses and Dissertations

The purpose of this study was to describe diet and/or physical activity-based interventions and their control in cardiometabolic risk factors of diabetes for the South Asian (SA) population. A systematic review was conducted in accordance with the PRISMA guidelines. Seventeen randomized control trials meeting the inclusion criteria were included for analysis. Interventions with type-2 diabetic SA showed significant improvements in HbA1c% (4/5 studies), fasting blood glucose (3/4 studies), and postprandial glucose (2/2 studies). Interventions with at-risk/prediabetic and non-diabetic SA showed a modest change in overall outcomes, with significant change reported for post-prandial insulin (3/4 studies), BMI and weight (2/4 studies), …

The Role Of Footwear, Foot Orthosis And Training-Related Strategies In The Prevention Of Bone Stress Injuries: A Systematic Review And Meta-Analysis, Alexandre Lavigne, Dominic Chicoine, Jean-François Esculier, François Desmeules, Pierre Fremont, Blaise Dubois

International Journal of Exercise Science

International Journal of Exercise Science 16(3): 721-743, 2023. Objective: To evaluate the effectiveness of footwear, foot orthoses and training-related strategies to prevent lower extremity bone stress injury (BSI). Design: Systematic review and meta-analysis. Data sources: Four bibliographic databases (from inception until November 2021): Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and CINAHL. Eligibility criteria: Randomised controlled trials (RCTs) that assessed the risk of developing a BSI when using particular footwear, foot orthoses or training-related strategies such as muscle strengthening, stretching, and mechanical loading exercises. Results: Eleven studies were included in this systematic review. When wearing foot orthoses, the risk …

Effects Of Exercise On Cardiopulmonary Function In Patients With Obstructive Sleep Apnea: A Systematic Review And Meta-Analysis, Jiale Peng, Hong Ren

International Journal of Physical Activity and Health

Obstructive sleep apnea (OSA) is a common sleep disorder characterized by repeated episodes of apnea and hypopnea during sleep. Snoring and daytime sleepiness are the most common manifestations of OSA. Patients with OSA are considered to have poor cardiopulmonary function. Exercise has been proposed as a treatment for OSA that could lower apnea hypopnea indices (AHI) and improve sleep quality. Study shows that constantly aerobic exercise improved cardiopulmonary function in patients with chronic heart failure. However, whether exercise training will benefit cardiopulmonary functioning in patients with OSA is still in doubt. The purpose of this review is to investigate the …

Systematic Review Of Functional Outcomes In Cancer Rehabilitation, Alix Sleight, Lynn H. Gerber, Timothy F. Marshall, Alicia Livinski, Catherine M. Alfano, Shana Harrington Pt, Ph.D., Ann Marie Flores, Aneesha Virani, Xiaorong Hu, Sandra A. Mitchell, Mitra Varedi, Melissa Eden, Samah Hayek, Beverly Reigle, Anya Kerkman, Raquel Neves, Kathleen Jablonoski, Eileen Danaher Hacker, Virginia Sun, Robin Newman, Karen Kane Mcdonnell, Allison L'Hotta, Alana Schoenhals, Nicole L. Stout

Faculty Publications

Objective

To systematically review the evidence regarding rehabilitation interventions targeting optimal physical or cognitive function in adults with a history of cancer and describe the breadth of evidence as well as strengths and limitations across a range of functional domains.

Data Sources

PubMed, Cumulative Index to Nursing and Allied Health Plus, Scopus, Web of Science, and Embase. The time scope was January 2008 to April 2019.

Study Selection

Prospective, controlled trials including single- and multiarm cohorts investigating rehabilitative interventions for cancer survivors at any point in the continuum of care were included, if studies included a primary functional outcome measure. …

Functional Neuroimaging Techniques To Examine Falls And Cognition In Older Adults: A Systematic Review, Tia M. Seleem, Raphael Gabiazon

Undergraduate Student Research Internships Conference

Falls in older adults have been attributed to impaired cognition. There is potential for neuroimaging techniques to understand the biological components that are involved in the cognitive processes pertaining to falls. Therefore, the purpose of this systematic review was to analyze how functional neuroimaging can be used to examine the relationship between falls and cognition among older adults. The following five electronic databases were selected to identify peer-reviewed articles in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses: 1) Medline (via OVID), 2) PsycINFO (via OVID), 3) CINAHL (via EBSCO), 4) EMBASE (via OVID), and 5) Pubmed. …

Contextualizing The Impact Of Faculty-Led Short-Term Study Abroad On Students’ Global Competence: Characteristics Of Effective Programs, Colleen Fisher, Laurel Iverson Hitchcock, Ashley Neyer, Stacy C. Moak, Sarah Moore, Scott Marsalis

Journal of Global Awareness

Short-term faculty-led study abroad programs are high-impact pedagogical practices designed to enhance students' global competency. However, there is a gap in our understanding regarding the specific educational components of short-term faculty-led study abroad programs that promote global competency. This systematic review examined nearly two decades of research on such programs (n=86) to assess the educational components associated with increases in students' global competencies using Steinberg's (2017) educational components as a framework. Results indicated that the educational components included in global competency-building education abroad courses varied substantially across programs and global regions. The components most strongly supporting enhanced global competency were …

Characterization Of Mef2c-Related Disorders: Genotype, Phenotype, And Gene Pathway Dysregulation, Jessica Ann Cooley Coleman

All Dissertations

MEF2C­-related disorders are characterized by intellectual disability, developmental delay, lack of speech, seizures, stereotypic movements, hypotonia, and brain abnormalities and are caused by pathogenic alterations involving the MEF2C gene. Despite published cases, MEF2C­-related disorders are difficult to recognize clinically. These studies sought to further characterize MEF2C­-related disorders by investigating the genotypes, phenotypes, and gene functions (or dysfunctions) associated with the disorder.

Tremors have been reported in some patients with MEF2C­-related disorders, but the concept of tremors has been complicated by vague definitions and numerous categorization methods. We performed a concept analysis following the Walker and Avant …

Exercise Interventions For Relieving Anxiety Symptoms For People With Autism Spectrum Disorder: A Systematic Review, Kathryn Riis

College of Health Sciences Posters

Background: Clinical anxiety is a common comorbidity in people with autism spectrum disorder (ASD). The focus of interventional therapies tends to be activities which improve gross motor function, communication, social interactions, and other behavioral skills. Certain forms of exercise have been successful in lowering anxiety levels while improving physical function.

Objective: The purpose of this systematic review was to examine the effectiveness of the use of exercise as an intervention to reduce anxiety in people with ASD.

Methods: Two databases, PubMed and Medline, were searched utilizing key terms. This yielded 35 articles for review. PRISMA systematic search procedures identified 9 …

Exposure Characterization And Assessment Of Airborne Chemicals And Sars-Cov-2 Transmission In New York City Nail Salons, Amelia P. H. Watkins

Dissertations and Theses

Background: Currently, there are 156,000 people employed as manicurists or pedicurists in the United States. Employment in this sector is expected to grow by 10% over the next decade. Exposure assessments have revealed that salon workers are chronically exposed to a variety of substances that cause respiratory sensitization, developmental problems, contact dermatitis, blood, liver, and kidney issues, as well as nervous system impacts. Most recently, the SARS-Cov-2 pandemic has raised the issue of the vulnerability of nail salon workers to airborne infectious diseases as well. This dissertation aims to characterize and assess the chemical exposures that nail salon workers …

Effects Of Lycopene And The Mediterranean Diet On Prostate Cancer: A Critical Analysis Of The Data, Natalie Silk, Dianzheng Zhang

Research Day

Background: Prostate cancer (PCa) is one of the most widespread cancers diagnosed in men in the United States and is the second leading cause of cancer-related deaths worldwide. PCa will be a major cancer-related burden both socially and economically in the near future. It has been shown that dietary intake of natural anti-inflammatory agents are capable of inhibiting cancer progression, but due to the nature of dietary studies it is difficult to accurately conclude that diet is capable of impacting chronic diseases and mortality.This systematic review aims to collect and evaluate literature focused on prostate cancer progression and the natural …

Systematic Review Of Race/Ethnicity In Parkinson's Disease, Amia Fisher

Honors Theses

The goal of this study was to examine race/ethnicity with an emphasis on African Ancestry in Parkinson’s Disease (PD) through a systematic review. Out of 448 scholarly articles that were originally extracted from the search, 445 were excluded due to their irrelevance regarding race/ethnicity and African ancestry in PD. Three scholarly articles were obtained through a PubMed/MEDLINE search for the review. Amongst the three sources that were chosen, there were more than 450,000 participants with PD that ranged in ages 40-65+; each case of PD within these studies were reported from 1993-2005. The varying races/ethnicities of White/non-Hispanic White, Black/African American, …

A Systematic Review Of Brainstem Contributions To Autism Spectrum Disorder, Ala Seif, Carly Shea, Susanne Schmid, Ryan A Stevenson

Anatomy and Cell Biology Publications

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects one in 66 children in Canada. The contributions of changes in the cortex and cerebellum to autism have been studied for decades. However, our understanding of brainstem contributions has only started to emerge more recently. Disruptions of sensory processing, startle response, sensory filtering, sensorimotor gating, multisensory integration and sleep are all features of ASD and are processes in which the brainstem is involved. In addition, preliminary research into brainstem contribution emphasizes the importance of the developmental timeline rather than just the mature brainstem. Therefore, the purpose of this systematic review …

Validity And Reliability Of Physiological Data In Applied Settings Measured By Wearable Technology: A Rapid Systematic Review, Bryson Carrier, Brenna Barrios, Brayden D. Jolley, James W. Navalta

Kinesiology and Nutrition Sciences Faculty Publications

The purpose of this review was to evaluate the current state of the literature and to identify the types of study designs, wearable devices, statistical tests, and exercise modes used in validation and reliability studies conducted in applied settings/outdoor environments. This was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We identified nine articles that fit our inclusion criteria, eight of which tested for validity and one tested for reliability. The studies tested 28 different devices with exercise modalities of running, walking, cycling, and hiking. While there were no universally common analytical techniques used …

Effects Of Vitamin D Supplementation On Lipid Profile In Adults With The Metabolic Syndrome: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Fatme Alanouti, Myriam Abboud, Dimitrios Papandreou, Nadine Mahboub, Suzan Haidar, Rana Rizk

All Works

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Background: Metabolic syndrome (MetS) increases the risk of cardiovascular disease, with atherogenic dyslipidemia being a major contributing factor. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement to assess whether vitamin D supplementation (VDS) alleviates dyslipidemia in adults with MetS. Scientific databases (PUBMED, MEDLINE, CINAHL, EMBASE, Cochrane Library, ClinicalTrials.gov, International Clinical Trials Registry Platform) and the gray literature were searched for randomized controlled trials of VDS, reporting on blood lipids. A narrative review, meta-analyses, sensitivity analyses, and appraisal of the risk of …

Antecedents Of Career Development Success: Insights Into 10 Years Of Research, Sara Karam Nassredine, Nasser Fathi Easa

BAU Journal - Creative Sustainable Development

This paper intends to review a flow of previous literature on the antecedents of career development success over ten years, from 2008 to 2018. A systematic literature review has been employed to extract the constitution of literature. A total of 41 relevant articles have been extracted from 16 different top ranked journals. Drawing on the literature, a conceptual model is provided as a clear depiction of what has been studied. Specifically, dependent, independents, mediators, and moderators variables are determined. The systematic literature review identifies six main themes; leadership, organizational and individual commitment, talent management, human resources management practices, career management …

Vitamin D Supplementation And Blood Pressure In Children And Adolescents: A Systematic Review And Meta-Analysis, Myriam Abboud

All Works

© 2020 by the author. Licensee MDPI, Basel, Switzerland. Suboptimal vitamin D status is associated with elevated blood pressure (BP) in children and adolescents. Whether vitamin D supplementation reduces BP remains unclear. To systematically review whether vitamin D supplementation reduces BP in children and adolescents, we conducted a literature review according to the PRISMA statement. We included vitamin-D supplementation human interventions studies that reported on BP as an outcome. We searched PUBMED, MEDLINE, CINAHL, EMBASE, the Cochrane Library, and the clinical trials website. We also hand searched the references of the included articles and previous reviews of vitamin D therapy. …

Evidence-Based Toxicology For The 21st Century: Opportunities And Challenges, Martin L. Stephens, Melvin E. Andersen, Richard A. Becker, Kellyn Betts, Kim Boekelheide, Ed Carney, Robert Chapin, Dennis Devlin, Suzanne C. Fitzpatrick, John R. Fowle Iii, Patricia Harlow, Thomas Hartung, Sebastian Hoffman, Michael P. Holsapple, Abigail Jacobs, Richard Judson, Olga Naidenko, Tim Pastoor, Grace Patlewicz, Andrew Rowan, Roberta Scherer, Rashid Shaikh, Ted Simon, Douglas Wolf, Joanne Zurlo

Martin Stephens, PhD

The Evidence-based Toxicology Collaboration (EBTC) was established recently to translate evidence-based approaches from medicine and health care to toxicology in an organized and sustained effort. The EBTC held a workshop on “Evidence-based Toxicology for the 21st Century: Opportunities and Challenges” in Research Triangle Park, North Carolina, USA on January 24-25, 2012. The presentations largely reflected two EBTC priorities: to apply evidence-based methods to assessing the performance of emerging pathwaybased testing methods consistent with the 2007 National Research Council report on “Toxicity Testing in the 21st Century” as well as to adopt a governance structure and work processes to move that …

Adaptation Of The Systematic Review Framework To The Assessment Of Toxicological Test Methods: Challenges And Lessons Learned With The Zebrafish Embryotoxicity Test, Martin L. Stephens, Sevcan Gül Akgün-Ölmez, Sebastian Hoffman, Rob De Vries, Burkhard Flick, Thomas Hartung, Manoj Lalu, Alexandra Maertens, Hilda Witters, Robert Wright, Katya Tsaioun

Martin Stephens, PhD

Systematic review methodology is a means of addressing specific questions through structured, consistent, and transparent examinations of the relevant scientific evidence. This methodology has been used to advantage in clinical medicine, and is being adapted for use in other disciplines. Although some applications to toxicology have been explored, especially for hazard identification, the present preparatory study is, to our knowledge, the first attempt to adapt it to the assessment of toxicological test methods. As our test case, we chose the zebrafish embryotoxicity test (ZET) for developmental toxicity and its mammalian counterpart, the standard mammalian prenatal development toxicity study, focusing the …

Adaptation Of The Systematic Review Framework To The Assessment Of Toxicological Test Methods: Challenges And Lessons Learned With The Zebrafish Embryotoxicity Test, Martin L. Stephens, Sevcan Gül Akgün-Ölmez, Sebastian Hoffman, Rob De Vries, Burkhard Flick, Thomas Hartung, Manoj Lalu, Alexandra Maertens, Hilda Witters, Robert Wright, Katya Tsaioun

Toxicology and Animal Models in Research Collection

Systematic review methodology is a means of addressing specific questions through structured, consistent, and transparent examinations of the relevant scientific evidence. This methodology has been used to advantage in clinical medicine, and is being adapted for use in other disciplines. Although some applications to toxicology have been explored, especially for hazard identification, the present preparatory study is, to our knowledge, the first attempt to adapt it to the assessment of toxicological test methods. As our test case, we chose the zebrafish embryotoxicity test (ZET) for developmental toxicity and its mammalian counterpart, the standard mammalian prenatal development toxicity study, focusing the …

Vitamin D Status And Risk Of Incident Tuberculosis Disease: A Nested Case-Control Study, Systematic Review, And Individual-Participant Data Meta-Analysis, Omowunmi Aibana, Chuan-Chin Huang, Said Aboud, Alberto Arnedo-Pena, Mercedes C. Becerra, Juan Bautista Bellido-Blasco, Ramesh Bhosale, Roger Calderon, Rabia Hussain, Najeeha Talat Iqbal

Department of Pathology and Laboratory Medicine

Background: Few studies have evaluated the association between preexisting vitamin D deficiency and incident tuberculosis (TB). We assessed the impact of baseline vitamins D levels on TB disease risk.
Methods and Findings: We assessed the association between baseline vitamin D and incident TB in a prospective cohort of 6,751 HIV-negative household contacts of TB patients enrolled between September 1, 2009, and August 29, 2012, in Lima, Peru. We screened for TB disease at 2, 6, and 12 months after enrollment. We defined cases as household contacts who developed TB disease at least 15 days after enrollment of the index patient. …

Bias During The Evaluation Of Animal Studies, Andrew Knight

Andrew Knight, Ph.D.

My recent book entitled The Costs and Benefits of Animal Experiments seeks to answer a key question within animal ethics, namely: is animal experimentation ethically justifiable? Or, more precisely, is it justifiable within the utilitarian cost:benefit framework that fundamentally underpins most regulations governing animal experimentation? To answer this question I reviewed more than 500 scientific publications describing animal studies, animal welfare impacts, and alternative research, toxicity testing and educational methodologies. To minimise bias I focused primarily on large-scale systematic reviews that had examined the human clinical and toxicological utility of animal studies. Despite this, Dr. Susanne Prankel recently reviewed my …

A Systematic Review Of Genetic Influence On Psychological Resilience, Kosuke Niitsu, Michael J. Rice, Julia F. Houfek, Scott F. Stoltenberg, Kevin A. Kupzyk, Cecilia R. Barron

Department of Psychology: Faculty Publications

When exposed to adversity, some individuals are at an increased risk of posttraumatic stress disorder, experiencing persistent biopsychosocial disturbances, whereas others adapt well, described as resilience. Resilience is a complex biopsychosocial phenomenon conceptualized as adaptation to adversity influenced by an individual’s genetic variants, epistasis, epigenetics, and gene-by-environment interactions. Studies on psychological resilience have focused on behavioral and psychosocial variables with far less examination of the genetic contributions. The purpose of this review is to identify specific genetic variants contributing to the biological capacity for psychological resilience. PubMed and PsycINFO were searched using the following key words: psychological resilience AND genotype …

Efficacy And Tolerability Of Atomoxetine Use For Patients With Autism Spectrum Disorders And Attention-Deficit/Hyperactivity Disorder (Adhd) Symptoms: A Systematic Review And Meta-Analysis, Angie El-Said

Honors Undergraduate Theses

Introduction: Patients with autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) show more symptoms of ADHD. Since there are more adverse events caused by psychostimulants compared to non-psychostimulants, the use of a non-psychostimulant such as atomoxetine might prove more beneficial for younger patients and/or those with comorbid ADHD. Objective: The aim of this thesis is to determine the efficacy and tolerability of atomoxetine in ASD patients presenting with ADHD, by examining (a) differences in ADHD symptoms for participants receiving atomoxetine versus those receiving placebos, and (b) risk differences in adverse events between these participants. Methods: An electronic search of both …

Current State Of Commercial Wearable Technology In Physical Activity Monitoring 2015-2017, Jennifer Bunn, James W. Navalta, Charles J. Fountaine, Joel Reece

International Journal of Exercise Science

International Journal of Exercise Science 11(7): 503-515, 2018. Wearable physical activity trackers are a popular and useful method to collect biometric information at rest and during exercise. The purpose of this systematic review was to summarize recent findings of wearable devices for biometric information related to steps, heart rate, and caloric expenditure for several devices that hold a large portion of the market share. Searches were conducted in both PubMed and SPORTdiscus. Filters included: humans, within the last 5 years, English, full-text, and adult 19+ years. Manuscripts were retained if they included an exercise component of 5-min or greater and …

The Epidemiology And Economic Burden Of Obesity And Related Cardiometabolic Disorders In The United Arab Emirates: A Systematic Review And Qualitative Synthesis, Hadia Radwan, Rami A. Ballout, Hayder Hasan, Nader Lessan, Mirey Karavetian, Rana Rizk

All Works

Copyright © 2018 Hadia Radwan et al. Background. Noncommunicable diseases (NCDs) are considered as a global health problem and considered as a public health priority with the more considerable increasing trend of obesity and cardiometabolic disorders rates in the Middle Eastern countries. This systematic review aims at assessing the prevalence, incidence rates, and trends, as well as the cost of obesity and related cardiometabolic disorders in the United Arab Emirates (UAE). Methods. A highly sensitive strategy was used to retrieve original observational studies, addressing the epidemiology and cost of obesity and related cardiometabolic disorders in the UAE, irrespective of nationality …

Neurofeedback With Fmri: A Critical Systematic Review, Robert T. Thibault, Amanda Macpherson, Michael Lifshitz, Raquel R. Roth, Amir Raz

Psychology Faculty Articles and Research

Neurofeedback relying on functional magnetic resonance imaging (fMRI-nf) heralds new prospects for self-regulating brain and behavior. Here we provide the first comprehensive review of the fMRI-nf literature and the first systematic database of fMRI-nf findings. We synthesize information from 99 fMRI-nf experiments—the bulk of currently available data. The vast majority of fMRI-nf findings suggest that self-regulation of specific brain signatures seems viable; however, replication of concomitant behavioral outcomes remains sparse. To disentangle placebo influences and establish the specific effects of neurofeedback, we highlight the need for double-blind placebo-controlled studies alongside rigorous and standardized statistical analyses. Before fMRI-nf can join the …

Optimal Nutrition For Endurance Exercise: A Systematic Review, Sarah E. Andrus Ms, Bruce W. Andrus Md Ms

Dartmouth Scholarship

Introduction

As fatigue in endurance events correlates with depletion of muscle glycogen, the traditional approach to nutritional support has been carbohydrate loading. However, there has been recent interest in improving athletic endurance performance by novel diets in the days to weeks prior to endurance events, the pre-event meal, and during exercise.

Methods

We searched PubMed and SCOPUS for randomized trials published from 1992-2017 with a primary endpoint of endurance performance. We identified 407 citations which were examined against our inclusion criteria of randomization or crossover allocation to diet and for which a primary outcome was endurance performance.

Results

Twenty full …

Therapeutic Strategies And Drug Development For Vascular Cognitive Impairment, Eric E. Smith, Alicja Cieslak, Philip Barber, Jerry Chen, Yu-Wei Chen, Ida Donnini, Jodi D. Edwards, Richard Frayne, Thalia S. Field, Janka Hegedus, Victoria Hanganu, Zahinoor Ismail, Jamila Kanji, Makoto Nakajima, Raza Noor, Stefano Peca, Demetrios Sahlas, Mukul Sharma, Luciano A. Sposato, Richard H. Swartz, Charlotte Zerna, Sandra E. Black, Vladimir Hachinski

Anatomy and Cell Biology Publications

No abstract provided.

Interspecies Communication In Homo Sapiens And Canis Lupis Familiaris: A Meta Analysis, Karissa Panzino

Honors College

Interspecies communication is a fundamental aspect of many creatures. Knowing what another animal is saying could not only prove interesting, it could quite literally save a life. For humans, human-canine communication is arguably the most prevalent form of interspecies communication, and is important not only because of the close proximity of humans to dogs, but also because of the co-evolutionary aspects that have driven humans closer to “man’s best friend”. While there are some sources that allow for a consistent analysis of results in this field, it is still developing and constantly changing. A meta-analysis was performed to identify sources …