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Full-Text Articles in Life Sciences
Integrated Structural And Functional Analysis Of The Protective Effects Of Kinetin Against Oxidative Stress In Mammalian Cellular Systems, Muhammad Naseem, Eman M. Othman, Moustafa Fathy, Jibran Iqbal, Fares M. Howari, Fatima A. Alremeithi, Geema Kodandaraman, Helga Stopper, Elena Bencurova, Dimitrios Vlachakis, Thomas Dandekar
Integrated Structural And Functional Analysis Of The Protective Effects Of Kinetin Against Oxidative Stress In Mammalian Cellular Systems, Muhammad Naseem, Eman M. Othman, Moustafa Fathy, Jibran Iqbal, Fares M. Howari, Fatima A. Alremeithi, Geema Kodandaraman, Helga Stopper, Elena Bencurova, Dimitrios Vlachakis, Thomas Dandekar
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© 2020, The Author(s). Metabolism and signaling of cytokinins was first established in plants, followed by cytokinin discoveries in all kingdoms of life. However, understanding of their role in mammalian cells is still scarce. Kinetin is a cytokinin that mitigates the effects of oxidative stress in mammalian cells. The effective concentrations of exogenously applied kinetin in invoking various cellular responses are not well standardized. Likewise, the metabolism of kinetin and its cellular targets within the mammalian cells are still not well studied. Applying vitality tests as well as comet assays under normal and hyper-oxidative states, our analysis suggests that kinetin …
Calcium Signaling In The Ventricular Myocardium Of The Goto-Kakizaki Type 2 Diabetic Rat, L. Al Kury, M. Smail, M. A. Qureshi, V. Sydorenko, A. Shmygol, M. Oz, J. Singh, F. C. Howarth
Calcium Signaling In The Ventricular Myocardium Of The Goto-Kakizaki Type 2 Diabetic Rat, L. Al Kury, M. Smail, M. A. Qureshi, V. Sydorenko, A. Shmygol, M. Oz, J. Singh, F. C. Howarth
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© 2018 L. Al Kury et al. The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients' age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+ transport in the Goto-Kakizaki …
Coral Spawning In The Gulf Of Oman And Relationship To Latitudinal Variation In Spawning Season In The Northwest Indian Ocean, E. J. Howells, D. Abrego, G. O. Vaughan, J. A. Burt
Coral Spawning In The Gulf Of Oman And Relationship To Latitudinal Variation In Spawning Season In The Northwest Indian Ocean, E. J. Howells, D. Abrego, G. O. Vaughan, J. A. Burt
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Despite a wealth of information on sexual reproduction in scleractinian corals, there are regional gaps in reproductive records. In the Gulf of the Oman in the Arabian Sea, reproductive timing was assessed in four common species of broadcast spawning corals using field surveys of gamete maturity and aquarium observations of spawning activity. The appearance of mature gametes within the same month for Acropora downingi, A. hemprichii, Cyphastrea microphthalma and Platygyra daedalea (≥ 75% of colonies, n = 848) indicated a synchronous and multi-specific spawning season. Based on gamete disappearance and direct observations, spawning predominantly occurred during April in 2013 (75- …
Dmsp Biosynthesis By An Animal And Its Role In Coral Thermal Stress Response, Jean Baptiste Raina, Dianne M. Tapiolas, Sylvain Forêt, Adrian Lutz, David Abrego, Janja Ceh, Francois O. Seneca, Peta L. Clode, David G. Bourne, Bette L. Willis, Cherie A. Motti
Dmsp Biosynthesis By An Animal And Its Role In Coral Thermal Stress Response, Jean Baptiste Raina, Dianne M. Tapiolas, Sylvain Forêt, Adrian Lutz, David Abrego, Janja Ceh, Francois O. Seneca, Peta L. Clode, David G. Bourne, Bette L. Willis, Cherie A. Motti
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Globally, reef-building corals are the most prolific producers of dimethylsulphoniopropionate (DMSP), a central molecule in the marine sulphur cycle and precursor of the climate-active gas dimethylsulphide. At present, DMSP production by corals is attributed entirely to their algal endosymbiont, Symbiodinium. Combining chemical, genomic and molecular approaches, we show that coral juveniles produce DMSP in the absence of algal symbionts. DMSP levels increased up to 54% over time in newly settled coral juveniles lacking algal endosymbionts, and further increases, up to 76%, were recorded when juveniles were subjected to thermal stress. We uncovered coral orthologues of two algal genes recently identified …