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Articles 1 - 30 of 110
Full-Text Articles in Life Sciences
Monarch Science Observer, Volume 7, College Of Sciences, Old Dominion University
Monarch Science Observer, Volume 7, College Of Sciences, Old Dominion University
College of Sciences Newsletter
December-Fall 2020 issue of Monarch Science Observer, ODU College of Sciences Newsletter.
Exploring The Niche Of Rickettsia Montanensis (Rickettsiales: Rickettsiaceae) Infection Of The American Dog Tick (Acari: Ixodidae), Using Multiple Species Distribution Model Approaches, Catherine A. Lippi, Holly Gaff, Alexis L. White, Heidi K. St. John, Allen L. Richards, Sadie J. Ryan
Exploring The Niche Of Rickettsia Montanensis (Rickettsiales: Rickettsiaceae) Infection Of The American Dog Tick (Acari: Ixodidae), Using Multiple Species Distribution Model Approaches, Catherine A. Lippi, Holly Gaff, Alexis L. White, Heidi K. St. John, Allen L. Richards, Sadie J. Ryan
Biological Sciences Faculty Publications
The American dog tick, Dermacentor variabilis (Say) (Acari: Ixodidae), is a vector for several human diseasecausing pathogens such as tularemia, Rocky Mountain spotted fever, and the understudied spotted fever group rickettsiae (SFGR) infection caused by Rickettsia montanensis. It is important for public health planning and intervention to understand the distribution of this tick and pathogen encounter risk. Risk is often described in terms of vector distribution, but greatest risk may be concentrated where more vectors are positive for a given pathogen. When assessing species distributions, the choice of modeling framework and spatial layers used to make predictions are important. …
Fine-Scale Patterns Of Genetic Structure In The Host Plant Chamaecrista Fasciculata (Fabaceae) And Its Nodulating Rhizobia Symbionts, Mahboubeh Hosseinalizadeh Nobarinezhad, Lisa A. Wallace
Fine-Scale Patterns Of Genetic Structure In The Host Plant Chamaecrista Fasciculata (Fabaceae) And Its Nodulating Rhizobia Symbionts, Mahboubeh Hosseinalizadeh Nobarinezhad, Lisa A. Wallace
Biological Sciences Faculty Publications
In natural plant populations, a fine-scale spatial genetic structure (SGS) can result from limited gene flow, selection pressures or spatial autocorrelation. However, limited gene flow is considered the predominant determinant in the establishment of SGS. With limited dispersal ability of bacterial cells in soil and host influence on their variety and abundance, spatial autocorrelation of bacterial communities associated with plants is expected. For this study, we collected genetic data from legume host plants, Chamaecrista fasciculata, their Bradyrhizobium symbionts and rhizosphere free-living bacteria at a small spatial scale to evaluate the extent to which symbiotic partners will have similar SGS …
In The Margins: Reconsidering The Range And Contribution Of Diazotrophs In Nearshore Environments, Corday R. Selden
In The Margins: Reconsidering The Range And Contribution Of Diazotrophs In Nearshore Environments, Corday R. Selden
OES Theses and Dissertations
Dinitrogen (N2) fixation enables primary production and, consequently, carbon dioxide drawdown in nitrogen (N) limited marine systems, exerting a powerful influence over the coupled carbon and N cycles. Our understanding of the environmental factors regulating its distribution and magnitude are largely based on the range and sensitivity of one genus, Trichodesmium. However, recent work suggests that the niche preferences of distinct diazotrophic (N2 fixing) clades differ due to their metabolic and ecological diversity, hampering efforts to close the N budget and model N2 fixation accurately. Here, I explore the range of N2 fixation …
Ixodes Scapularis Src Kinase Is Required For Rickettsial Pathogen Survival In Ticks, Jeremy W. Turck
Ixodes Scapularis Src Kinase Is Required For Rickettsial Pathogen Survival In Ticks, Jeremy W. Turck
Biological Sciences Theses & Dissertations
Anaplasma phagocytophilum is an obligate intracellular bacterium that causes disease in humans and animals. It is the causative agent for human anaplasmosis. A. phagocytophilum uses certain strategies to infect both vertebrates and invertebrates. It uses Ixodes scapularis ticks as a vector for spreading infection to other mammal species. This bacterium has a specific path for infection through the salivary glands of its vector host. It also suppresses certain functions such as the inhibition of apoptosis and ROS production in order to increase its survival in ticks. Src kinase, a non-receptor protein-tyrosine kinase, is a major player in cell signaling. Src …
Assessment Of Factors Influencing Migratory Landbird Use Of Forested Stopover Sites Along The Delmarva Peninsula During Autumn Migration, J. Andrew Arnold
Assessment Of Factors Influencing Migratory Landbird Use Of Forested Stopover Sites Along The Delmarva Peninsula During Autumn Migration, J. Andrew Arnold
Biological Sciences Theses & Dissertations
Autumn migration is a time when billions of birds move from breeding grounds in North America to wintering grounds in Central and South America, with many individuals relying on stopover habitats en route for resting and refueling purposes. These stopover sites are critical to the survival of the hundreds of species of migratory landbirds that migrate annually, and thus identifying important stopover sites is a high priority for conserving such taxa. The Delmarva Peninsula; a coastal region of Delaware, Maryland, and Virginia along the mid-Atlantic flyway; consists of forested habitats with ample food and shelter that likely serves as quality …
Wicked Ideas For Wicked Problems: Marine Debris And The Complexity Of Governance, Dawn Helene Driesbach
Wicked Ideas For Wicked Problems: Marine Debris And The Complexity Of Governance, Dawn Helene Driesbach
Graduate Program in International Studies Theses & Dissertations
Myriad challenges regarding earth's common spaces, those unregulated by sovereign state authorities, mount and intensify as resources diminish and competition for commercial, scientific and security advantages increases; the pollution and degradation of those spaces simultaneously expands. Threats to the global commons complicate efforts to achieve international consensus which impedes attempts to develop effective governance. As an example, marine debris is a growing problem and is an existential threat to the global commons.
This dissertation aims to characterize marine debris as a wicked problem and explores the complexity of governance in the global ocean commons by answering two fundamental questions. Under …
Drivers Of Rickettsial Pathogen Transmission And Spillover In Local Tick Populations In Southeastern Virginia, Alexandra Cumbie
Drivers Of Rickettsial Pathogen Transmission And Spillover In Local Tick Populations In Southeastern Virginia, Alexandra Cumbie
Biomedical Sciences Theses & Dissertations
Cases of spotted fever group rickettsiosis are becoming more prevalent in the United States. In Virginia, there are three human-biting ticks which are largely responsible for the spread of rickettsial pathogens and the increase in disease cases. These species include Dermacentor variabilis, Amblyomma americanum, and Amblyomma maculatum; all of which are vectors of rickettsial agents to vertebrate hosts. These species are sympatric as adults and have the potential to share large and small mammal hosts. Their interactions on and off host and their associated rickettsiae were the focus of this dissertation work. Amblyomma americanum is the vector …
Global Conservation Status Of Croaker And Drum (Family: Sciaenidae) And Role Of The Maw Trade, Claire E. Gorman
Global Conservation Status Of Croaker And Drum (Family: Sciaenidae) And Role Of The Maw Trade, Claire E. Gorman
Biological Sciences Theses & Dissertations
Understanding threats and drivers of extinction risk is critical to conserving marine biodiversity. Although marine bony fishes are some of the most diverse and abundant vertebrates in the world, overexploitation is the major threat to these taxa. Species in the family Sciaenidae are important marine resources in many parts of the world, supporting small- and large-scale fisheries for consumption and the international maw (dried swimbladder) trade. Sciaenids exhibit a diverse array of life history characteristics, such as high fecundity, large body size, formation of spawning aggregations, and longevity. Some characteristics increase their susceptibility to anthropogenic stressors. Despite being ecologically and …
Not Too Hot, Not Too Cold, But Moderately Variable: The Influence Of Environmental Variability On Coral Thermal Tolerance, Courtney Nicole Klepac
Not Too Hot, Not Too Cold, But Moderately Variable: The Influence Of Environmental Variability On Coral Thermal Tolerance, Courtney Nicole Klepac
Biological Sciences Theses & Dissertations
Anthropogenic climate change is causing an increase in the frequency and severity of marine heat waves, resulting in declining health of coral reef ecosystems worldwide. Coral bleaching events – the breakdown in symbiosis between the coral host and their intracellular photosynthetic algae – are increasingly common in recent years and contribute to widespread losses in coral cover. However, bleaching and heat stress responses vary across spatial scales both within and among coral species. Coral populations native to highly variable environments can have greater bleaching resistance than corals from more stable habitats and corals transplanted into these variable reef sites can …
Varroa Destructor Mites Vector And Transmit Pathogenic Honey Bee Viruses Acquired From An Artificial Diet, Francisco Posada-Florez, Eugene V. Ryabov, Matthew C. Heerman, Yanping Chen, Jay D. Evans, Daniel E. Sonenshine, Steven C. Cook
Varroa Destructor Mites Vector And Transmit Pathogenic Honey Bee Viruses Acquired From An Artificial Diet, Francisco Posada-Florez, Eugene V. Ryabov, Matthew C. Heerman, Yanping Chen, Jay D. Evans, Daniel E. Sonenshine, Steven C. Cook
Biological Sciences Faculty Publications
The ectoparasitic mite Varroa destructoris one of the most destructive pests of the honey bee (Apis mellifera) and the primary biotic cause of colony collapse in many regions of the world. These mites inflict physical injury on their honey bee hosts from feeding on host hemolymph and fat body cells/cellular components, and serve as the vector for deadly honey bee viruses, including Deformed wing virus (DWV) and the related Varroa destructor virus-1 (VDV-1) (i.e., DWV-like viruses). Studies focused on elucidating the dynamics of Varroa-mediated vectoring and transmission of DWV-like viruses may be confounded by viruses present in …
Modulation Of Ros In Nanosecond-Pulsed Plasma-Activated Media For Dosage-Dependent Cancer Cell Inactivation In Vitro, Chunqi Jiang, Esin Bengisu Sozer, Shutong Song, Nicola Lai, P. Thomas Vernier, Sigi Guo
Modulation Of Ros In Nanosecond-Pulsed Plasma-Activated Media For Dosage-Dependent Cancer Cell Inactivation In Vitro, Chunqi Jiang, Esin Bengisu Sozer, Shutong Song, Nicola Lai, P. Thomas Vernier, Sigi Guo
Bioelectrics Publications
Dosage control of reactive oxygen and nitrogen species (RONS) is critical to low-temperature plasma applications in cancer therapy. Production of RONS by atmospheric pressure, nonequilibrium plasmas in contact with liquid may be modulated via plasma conditions including plasma treatment time and pulse voltage and repetition frequency. In this study, a terephthalic acid-based probe was used to measure hydroxyl radicals [OHaq] in water exposed to plasma and to demonstrate that the OHag concentration increases linearly with treatment time. Fluorometric measurements of hydrogen peroxide concentration in plasma-activated water show a linear relationship between the H2O2 production …
Adaptive Divergence, Neutral Panmixia, And Algal Symbiont Population Structure In The Temperate Coral Astrangia Poculata Along The Mid-Atlantic United States, Hannah E. Aichelman, Daniel J. Barshis
Adaptive Divergence, Neutral Panmixia, And Algal Symbiont Population Structure In The Temperate Coral Astrangia Poculata Along The Mid-Atlantic United States, Hannah E. Aichelman, Daniel J. Barshis
Biological Sciences Faculty Publications
Astrangia poculata is a temperate scleractinian coral that exists in facultative symbiosis with the dinoflagellate alga Breviolum psygmophilum across a range spanning the Gulf of Mexico to Cape Cod, Massachusetts. Our previous work on metabolic thermal performance of Virginia (VA) and Rhode Island (RI) populations of A. poculata revealed physiological signatures of cold (RI) and warm (VA) adaptation of these populations to their respective local thermal environments. Here, we used whole-transcriptome sequencing (mRNA-Seq) to evaluate genetic differences and identify potential loci involved in the adaptive signature of VA and RI populations. Sequencing data from 40 A. poculata individuals, including 10 …
An Accurate Vegetation And Non-Vegetation Differentiation Approach Based On Land Cover Classification, Chiman Kwan, David Gribben, Bulent Ayhan, Jiang Li, Sergio Bernabe, Antonio Plaza
An Accurate Vegetation And Non-Vegetation Differentiation Approach Based On Land Cover Classification, Chiman Kwan, David Gribben, Bulent Ayhan, Jiang Li, Sergio Bernabe, Antonio Plaza
Electrical & Computer Engineering Faculty Publications
Accurate vegetation detection is important for many applications, such as crop yield estimation, landcover land use monitoring, urban growth monitoring, drought monitoring, etc. Popular conventional approaches to vegetation detection incorporate the normalized difference vegetation index (NDVI), which uses the red and near infrared (NIR) bands, and enhanced vegetation index (EVI), which uses red, NIR, and the blue bands. Although NDVI and EVI are efficient, their accuracies still have room for further improvement. In this paper, we propose a new approach to vegetation detection based on land cover classification. That is, we first perform an accurate classification of 15 or more …
Potential Virus-Mediated Nitrogen Cycling In Oxygen-Depleted Oceanic Waters, M. Consuelo Gazitúa, Dean R. Vik, Simon Roux, Ann C. Gregory, Benjamin Bolduc, Brittany Widner, Margaret R. Mulholland, Steven J. Hallam, Osvaldo Ulloa, Matthew B. Sullivan
Potential Virus-Mediated Nitrogen Cycling In Oxygen-Depleted Oceanic Waters, M. Consuelo Gazitúa, Dean R. Vik, Simon Roux, Ann C. Gregory, Benjamin Bolduc, Brittany Widner, Margaret R. Mulholland, Steven J. Hallam, Osvaldo Ulloa, Matthew B. Sullivan
OES Faculty Publications
Viruses play an important role in the ecology and biogeochemistry of marine ecosystems. Beyond mortality and gene transfer, viruses can reprogram microbial metabolism during infection by expressing auxiliary metabolic genes (AMGs) involved in photosynthesis, central carbon metabolism, and nutrient cycling. While previous studies have focused on AMG diversity in the sunlit and dark ocean, less is known about the role of viruses in shaping metabolic networks along redox gradients associated with marine oxygen minimum zones (OMZs). Here, we analyzed relatively quantitative viral metagenomic datasets that profiled the oxygen gradient across Eastern Tropical South Pacific (ETSP) OMZ waters, assessing whether OMZ …
Biomechanical And Biophysical Properties Of Breast Cancer Cells Under Varying Glycemic Regimens, Diganta Dutta, Xavier-Lewis Palmer, Jose Ortega-Rodas, Vasundhara Balraj, Indrani Ghosh Dastider, Surabhi Chandra
Biomechanical And Biophysical Properties Of Breast Cancer Cells Under Varying Glycemic Regimens, Diganta Dutta, Xavier-Lewis Palmer, Jose Ortega-Rodas, Vasundhara Balraj, Indrani Ghosh Dastider, Surabhi Chandra
Electrical & Computer Engineering Faculty Publications
Diabetes accelerates cancer cell proliferation and metastasis, particularly for cancers of the pancreas, liver, breast, colon, and skin. While pathways linking the 2 disease conditions have been explored extensively, there is a lack of information on whether there could be cytoarchitectural changes induced by glucose which predispose cancer cells to aggressive phenotypes. It was thus hypothesized that exposure to diabetes/high glucose alters the biomechanical and biophysical properties of cancer cells more than the normal cells, which aids in advancing the cancer. For this study, atomic force microscopy indentation was used through microscale probing of multiple human breast cancer cells (MCF-7, …
Deepfrag-K: A Fragment-Based Deep Learning Approach For Protein Fold Recognition, Wessam Elhefnawy, Min Li, Jianxin Wang, Yaohang Li
Deepfrag-K: A Fragment-Based Deep Learning Approach For Protein Fold Recognition, Wessam Elhefnawy, Min Li, Jianxin Wang, Yaohang Li
Computer Science Faculty Publications
Background: One of the most essential problems in structural bioinformatics is protein fold recognition. In this paper, we design a novel deep learning architecture, so-called DeepFrag-k, which identifies fold discriminative features at fragment level to improve the accuracy of protein fold recognition. DeepFrag-k is composed of two stages: the first stage employs a multi-modal Deep Belief Network (DBN) to predict the potential structural fragments given a sequence, represented as a fragment vector, and then the second stage uses a deep convolutional neural network (CNN) to classify the fragment vector into the corresponding fold.
Results: Our results show that DeepFrag-k yields …
Identification Of Planktothrix (Cyanobacteria) Blooms And Effects On The Aquatic Macroinvertebrate Community In The Non-Tidal Potomac River, Usa, Joshua Henesy, Jennifer L. Wolny, John E. Mullican, Detbra S. Rosales, Joseph S. Pitula, Joseph W. Love
Identification Of Planktothrix (Cyanobacteria) Blooms And Effects On The Aquatic Macroinvertebrate Community In The Non-Tidal Potomac River, Usa, Joshua Henesy, Jennifer L. Wolny, John E. Mullican, Detbra S. Rosales, Joseph S. Pitula, Joseph W. Love
Virginia Journal of Science
Using transverse cross-sectional transects, a survey of 31 km of the non-tidal Potomac River was conducted from White’s Ferry, Virginia to Brunswick, Maryland, USA, between June and September in 2013 through 2015 to assess a recurring benthic cyanobacteria bloom. Abundant benthic cyanobacteria blooms were detected during the 2014 and 2015 sampling seasons and the primary taxon was identified morphologically and molecularly as Planktothrix cf. isothrix. When present, P. cf. isothrix blooms were concentrated from river center to the Maryland shoreline. This pattern was correlated with significantly greater benthic chlorophyll-a and phycocyanin concentrations. In an apparent response to …
Monarch Science Observer, Volume 6, College Of Sciences, Old Dominion University
Monarch Science Observer, Volume 6, College Of Sciences, Old Dominion University
College of Sciences Newsletter
October-Fall 2020 issue of Monarch Science Observer, ODU College of Sciences Newsletter.
Central Administration Of Agouti-Related Peptide Increases Food Intake In Japanese Quail, Tyler Lindskoog, Mark Bohler, Elizabeth R. Gilbert, Mark A. Cline
Central Administration Of Agouti-Related Peptide Increases Food Intake In Japanese Quail, Tyler Lindskoog, Mark Bohler, Elizabeth R. Gilbert, Mark A. Cline
Virginia Journal of Science
Agouti-related peptide is a 132-amino acid peptide associated with stimulating food intake in birds and mammals. The aim of the present study was to investigate the effect of AgRP in 7-day old Japanese quail. In Experiment 1, we tested 0.25, 0.5 and 1.0 nmol AgRP and found no effect on food intake or water intake over a 3 hour duration. In Experiment 2, we tested we tested 0.25, 0.5 and 1.0 nmol AgRP and found no effect on food or water intake over a 24 hour duration. In Experiment 3, we tested 0.0625 and 0.125 nmol AgRP and found no …
Assessment Of Coordination And Proprioception In Youth With Autism Spectrum Disorder, Taylor Kristina Jones
Assessment Of Coordination And Proprioception In Youth With Autism Spectrum Disorder, Taylor Kristina Jones
Human Movement Sciences Theses & Dissertations
Autism spectrum disorder (ASD) is characterized by social and communicative delays. It is known that those with ASD exhibit lower activity levels and decreased proprioception to some extent. The biomechanics of movement in ASD has not been assessed thoroughly enough to provide information on ASD specific movement patterns, and no studies have been performed examining work and recovery. The purpose of this study is to examine whether 1) inter-limb and intra-limb coordination patterns during walking and running differ between youth with ASD and neurotypical sex, age, and BMI-matched controls. Youth with ASD (N=8) and their BMI, age, and sex matched …
Innovative Approaches In The Discovery Of Aquatic Mycobacteriophages, Janis H. Doss
Innovative Approaches In The Discovery Of Aquatic Mycobacteriophages, Janis H. Doss
Biomedical Sciences Theses & Dissertations
Bacteriophages (phages), viruses that infect bacteria, have many applications in medicine, agriculture, molecular biology, and other fields. As antibiotic resistance becomes an increasing problem, interest in phages has grown. The traditional techniques of phage discovery are successful for some phages, but others require modified procedures to achieve detectable host infection.
Mycobacterium is a diverse bacterial genus characterized by a unique cell wall containing mycolic acids, which aids in survival and pathogenesis. The aims of the present research were to isolate mycobacteriophages, use bioinformatics techniques to analyze mycobacterial prophages, and combine genetic analysis with multi-well plate host range studies to identify …
Validation Of Nanosecond Pulse Cancellation Using A Quadrupole Exposure System, Hollie A. Ryan
Validation Of Nanosecond Pulse Cancellation Using A Quadrupole Exposure System, Hollie A. Ryan
Biomedical Engineering Theses & Dissertations
Nanosecond pulsed electric fields (nsPEFs) offer a plethora of opportunities for developing integrative technologies as complements or alternatives to traditional medicine. Studies on the biological effects of nsPEFs in vitro and in vivo have revealed unique characteristics that suggest the potential for minimized risk of complications in patients, such as the ability of unipolar nsEPs to create permanent or transient pores in cell membranes that trigger localized lethal or non-lethal outcomes without consequential heating. A more recent finding was that such responses could be diminished by applying a bipolar pulse instead, a phenomenon dubbed bipolar cancellation, paving the way …
Do Different Pathologies Affect The Relationship Between The Stiffness Of The Plantar Fascia And The Function Of The Mtp Joint?, Madeline Ryan Pauley
Do Different Pathologies Affect The Relationship Between The Stiffness Of The Plantar Fascia And The Function Of The Mtp Joint?, Madeline Ryan Pauley
Biomedical Engineering Theses & Dissertations
Compared to healthy individuals, individuals with plantar fasciitis and diabetes experience material and structural property changes to soft tissues in the feet. The purpose of this study was to compare the relationship between material properties, power absorption, and energy storage characteristics to metatarsal power between healthy, plantar fasciitis symptomatic and asymptomatic, and diabetic participants. Investigating material change differences as well as energy storage and transfer trends in different pathology groups can lead to a better overall understanding of power transfer at the metatarsophalangeal joint (MTP). Participants were recruited for kinematic gait analysis and lower extremity shear wave elastography analysis and …
Monarch Science Observer, Volume 5, College Of Sciences, Old Dominion University
Monarch Science Observer, Volume 5, College Of Sciences, Old Dominion University
College of Sciences Newsletter
August-Summer 2020 issue of Monarch Science Observer, ODU College of Sciences Newsletter.
Aging, Gait Variability, And Adaptability, Collin Douglas Bowersock
Aging, Gait Variability, And Adaptability, Collin Douglas Bowersock
Health Services Research Dissertations
The purpose of this work was to study the relationships between age, measures of gait variability, and locomotor adaptability. Measures of gait variability are used to identify maladapted locomotor behavior, motor disease, and risk of falls. The first aim was to determine the relationships between age and measures of gait variability. Thirty-four participants (23-71 years old) walked on a treadmill for 6 minutes at their preferred speed. Variability of stride times and lengths was computed via linear measures (standard deviation and coefficient of variation) and nonlinear measures (sample entropy and detrended fluctuation analysis). Movement trajectory variability of the dominant knee …
Repression Of Tick Microrna-133 Induces Organic Anion Transporting Polypeptide Expression Critical For Anaplasma Phagocytophilumsurvival In The Vector And Transmission To The Vertebrate Host, Ellango Ramasamy, Vikas Taank, John F. Anderson, Hameeda Sultana, Girish Neelakanta
Repression Of Tick Microrna-133 Induces Organic Anion Transporting Polypeptide Expression Critical For Anaplasma Phagocytophilumsurvival In The Vector And Transmission To The Vertebrate Host, Ellango Ramasamy, Vikas Taank, John F. Anderson, Hameeda Sultana, Girish Neelakanta
Biological Sciences Faculty Publications
The microRNAs (miRNAs) are important regulators of gene expression. In this study, we provide evidence for the first time to show that rickettsial pathogen Anaplasma phagocytophilum infection results in the down-regulation of tick microRNA-133 (miR-133), to induce Ixodes scapularis organic anion transporting polypeptide (isoatp4056) gene expression critical for this bacterial survival in the vector and for its transmission to the vertebrate host. Transfection studies with recombinant constructs containing transcriptional fusions confirmed binding of miR-133 to isoatp4056 mRNA. Treatment with miR-133 inhibitor resulted in increased bacterial burden and isoatp4056 expression in ticks and tick cells. In contrast, treatment with …
Secretion Of Proteins And Antibody Fragments From Transiently Transfected Endothelial Progenitor Cells, Loree Heller, Reynald Thinard, Melanie Chevalier, Sezgi Arpag, Yu Jing, Ruth Greferath, Richard Heller, Claude Nicolau
Secretion Of Proteins And Antibody Fragments From Transiently Transfected Endothelial Progenitor Cells, Loree Heller, Reynald Thinard, Melanie Chevalier, Sezgi Arpag, Yu Jing, Ruth Greferath, Richard Heller, Claude Nicolau
Bioelectrics Publications
In neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis and amyotrophic lateral sclerosis, neuroinflammation can lead to blood-brain barrier (BBB) breakdown. After intravenous or intra-arterial injection into mice, endothelial progenitor cells (EPCs) home to the damaged BBB to promote neurovascular repair. Autologous EPCs transfected to express specific therapeutic proteins offer an innovative therapeutic option. Here, we demonstrate that EPC transfection by electroporation with plasmids encoding the reporter protein GFP or an anti-beta-amyloid antibody fragment (Fab) leads to secretion of each protein. We also demonstrate the secreted anti-beta-amyloid Fab protein functions in beta-amyloid aggregate solubilization.
Soil Labile Organic Carbon Fractions And Soil Enzyme Activities After 10 Years Of Continuous Fertilization And Wheat Residue Incorporation, Ligan Zhang, Xi Chen, Yujun Xu, Mengcan Jin, Xinxin Ye, Hongjian Gao, Wenying Chu, Jingdong Mao, Michael L. Thompson
Soil Labile Organic Carbon Fractions And Soil Enzyme Activities After 10 Years Of Continuous Fertilization And Wheat Residue Incorporation, Ligan Zhang, Xi Chen, Yujun Xu, Mengcan Jin, Xinxin Ye, Hongjian Gao, Wenying Chu, Jingdong Mao, Michael L. Thompson
Chemistry & Biochemistry Faculty Publications
Labile organic carbon (LOC) fractions and related enzyme activities in soils are considered to be early and sensitive indicators of soil quality changes. We investigated the influences of fertilization and residue incorporation on LOC fractions, enzyme activities, and the carbon pool management index (CPMI) in a 10-year field experiment. The experiment was composed of three treatments: (1) no fertilization (control), (2) chemical fertilizer application alone (F), and (3) chemical fertilizer application combined with incorporation of wheat straw residues (F + R). Generally, the F + R treatment led to the highest concentrations of the LOC fractions. Compared to the control …
Workshop #2: Health And Infection Control Measures During The 2020 Hurricane Season: After-Action Report (Aar), Converge Nsf Working Group, Joshua G, Behr, Wie Yusuf, Jennifer Marshall, Elizabeth Dunn
Workshop #2: Health And Infection Control Measures During The 2020 Hurricane Season: After-Action Report (Aar), Converge Nsf Working Group, Joshua G, Behr, Wie Yusuf, Jennifer Marshall, Elizabeth Dunn
Presentations, Lectures, Posters, Reports
Participants in the CONVERGE NSF Working Group Workshop 2 (Health) breakout sessions identified that along with populations traditionally considered vulnerable during hurricane season (e.g., special-needs evacuees and the elderly), there will be new vulnerable populations based on their heightened risks from exposure to COVID-19. There is also overlap between these groups of vulnerable evacuees, including individuals with physical, intellectual or developmental disabilities; those with immunodeficiency, chronic, acute, or infectious illnesses; pregnant women and infants; and immigrants, non-English speakers, and other socially vulnerable groups.
This indicates a potentially greater number of special-needs evacuees at shelters. Simultaneously, fear of contracting COVID-19, particularly …