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Using Crispr To Induce A Knock-Out Of Dprl-1 In Drosophila Melanogaster, Alicia Walker
Using Crispr To Induce A Knock-Out Of Dprl-1 In Drosophila Melanogaster, Alicia Walker
Summer Research
Phosphatase of regenerating liver (PRL) is a protein that controls cell processes such as growth and division which has unknown targets. PRL has been found to have both oncogenic and tumor suppressive properties. This study aimed to create a knock out of PRL in Drosohpila melanogaster in order to assess its role in development and in order to illuminate its activity when it is expressed in cancers. We hypothesize that dPRL-1 plays an important role in embryogenesis and that the progeny which lack this gene will be unviable. The CRISPR/Cas9 system was selected as the method in which to create …