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Assessment Of Tattoo And Silicone Wounds In Terms Of Time Of Treatment And Perceived Treatment Quality, M Pettitt
Electronic Theses and Dissertations
At the point of injury, critical medical tasks include locating and identifying an injury as well as applying the appropriate initial care. Over the past decade, to increase the fidelity of wound representation and ultimately the quality of medical care, a considerable amount of research and development has occurred to improve simulated wounds during training, primarily at the point of injury. As material and techniques mature and as more relevant data is collected on tissue properties, examining what fidelity is required for training at the point of injury is crucial. The main objective of this effort was to assess a …
Downregulation In Ifngr1 Increases Suspectiblity To Mycobacterium Avium Subspecies Paratuberculosis Infection In Crohn's Disease, Zin Mar Htun
Electronic Theses and Dissertations
BACKGROUND: Crohn's disease (CD) is an inflammatory bowel disease (IBD) and has been associated with Mycobacterium avium subspecies paratuberculosis (MAP). MAP has been detected in stool, tissue and blood samples from patients with CD. Gamma interferon (γ-IFN) is an inflammatory cytokine that plays a crucial role in killing intracellular pathogens like MAP, and its receptor (IFNGR1) mutations cause immunodeficiency and severe disseminated mycobacterial infections. The role of MAP in association with IFNGR1 mutation in CD patients have not been investigated. METHODS: In this study, we investigated blood samples of 79 human subjects for MAP infection in association with IFNGR1 gene …
Chaperonin Containing Tcp1 (Cct) As A Target For Cancer Therapy, Ana Carr
Chaperonin Containing Tcp1 (Cct) As A Target For Cancer Therapy, Ana Carr
Electronic Theses and Dissertations
Treatments for aggressive cancers like triple negative breast cancer (TNBC) and small-cell lung cancer (SCLC) have not improved and remain associated with debilitating side effects. There is an unmet medical need for better, druggable targets and improved therapeutics. To this end, we investigated the role of Chaperonin-Containing TCP1 (CCT), an evolutionarily conserved protein-folding complex composed of eight subunits (CCT1-8), in oncogenesis. Our laboratory was the first to report that the CCT2 subunit is highly expressed in breast cancer and could be therapeutically targeted. To determine whether CCT is a marker of disease progression in other cancers, we analyzed CCT2 gene …
Cathepsin B Regulates Vldl Secretion Through Lfabp Cleavage, Simeon Thibeaux
Cathepsin B Regulates Vldl Secretion Through Lfabp Cleavage, Simeon Thibeaux
Electronic Theses and Dissertations
The liver is tasked with managing the concentration of various metabolites in the blood, and of particular importance is the uptake of free fatty-acid (FFA), as elevated concentrations of FFA are toxic to cells. FFAs are transported across the cell membrane by CD36 and distributed by LFABP to the endoplasmic reticulum (ER), where they are esterified to glycerol, yielding more chemically inert triglyceride (TAG), which is essential to the process of VLDL assembly. VLDL secretion distributes energy rich TAG to peripheral tissues, and its dysfunction leads to hepatic steatosis, which may progress into hepatocellular carcinoma. The present study examined the …