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Th1 Cells In Cancer-Associated Inflammation, Güneş Di̇nç Akbulut, Di̇dem Özkazanç, Güneş Esendağli
Th1 Cells In Cancer-Associated Inflammation, Güneş Di̇nç Akbulut, Di̇dem Özkazanç, Güneş Esendağli
Turkish Journal of Biology
The immune system is not only evolved to protect the body from pathogens, but it also recognizes and eliminates cancer cells. CD4+ helper T (Th) lymphocytes are central intercessors differentiated according to the character of physiological or pathological status. Generation of type 1 Th (Th1) cells is primarily associated with a pathological insult that must be removed through immune elimination. Upon interacting with other immune and transformed cells, Th1 cells can hamper cancer progression. Therefore, it is a major obstacle for tumor cells to become insensitive or resistant to Th1-oriented actions. The organism employs various mechanisms to return to a …