Life Sciences Commons^™

K-Shell Decomposition Reveals Structural Properties Of The Gene Coexpression Network Forneurodevelopment, Abdullah Ercüment Çi̇çek

Turkish Journal of Biology

Neurodevelopment is a dynamic and complex process, which involves interactions of thousands of genes. Understanding the mechanisms of brain development is important for uncovering the genetic architectures of neurodevelopmental disorders such as autism spectrum disorder and intellectual disability. The BrainSpan dataset is an important resource for studying the transcriptional mechanisms governing neurodevelopment. It contains RNA-seq and microarray data for 13 developmental periods in 8?16 brain regions. Various important studies used this dataset, in particular to generate gene coexpression networks. The topology of the BrainSpan gene coexpression network yielded various important gene clusters, which are found to play key roles in …