Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
The Subjective Experience Of Mild Traumatic Brain Injury In Pediatric Patients, Ruta Clair, Mary Henigan, Sarah Allen, Katy Tresco
The Subjective Experience Of Mild Traumatic Brain Injury In Pediatric Patients, Ruta Clair, Mary Henigan, Sarah Allen, Katy Tresco
Research Day
Mild Traumatic Brain Injury is a neurologic insult that impacts a child’s functioning across domains. Risk factors include previous concussion history, force of impact, and gender. Current research regarding return to school following a brain injury suggests the need for accommodations in a number of areas of learning including changes in schedule, reduced exposure to screens and text, limitations to classroom expectations for tasks such as reading and note-taking, and modified testing. A one-size-fits-all approach to accommodations is problematic as recovery rates vary widely. Studies have also suggested that mood symptoms are comorbid with concussion recovery. Further, pediatric concussion patients …
The Effectiveness Of Coenzyme Q1 And Q10 In Mitigating Myocardial Reperfusion/Ischemia (Mi/R) Injury, Myles Ashitey, Jakob Sutton, Joseph Venditto, Kevin Kucharski, Jason Robbie, Daniel Kuo, Robert Barsotti, Lindon Young, Qian Chen
The Effectiveness Of Coenzyme Q1 And Q10 In Mitigating Myocardial Reperfusion/Ischemia (Mi/R) Injury, Myles Ashitey, Jakob Sutton, Joseph Venditto, Kevin Kucharski, Jason Robbie, Daniel Kuo, Robert Barsotti, Lindon Young, Qian Chen
Research Day
Mitochondria may be a principle source of oxidative stress causing MI/R injury. Coenzyme Q10 (CoQ10) is essential for electron transport in normal mitochondria, has antioxidant properties but its bioavailability is likely reduced due to oxidative stress during MI/R. Coenzyme Q1 (CoQ1) is a derivative of CoQ10, but is a more potent antioxidant than CoQ10 due to a shorter isoprene chain. We hypothesize that CoQ1 will exhibit better cardioprotective effects during MI/R. CoQ1 (MW=250 g/mol; 20 μM, n=5) and CoQ10 (MW=863 g/mol; 20 μM, n=5) were given at reperfusion in isolated rat hearts subjected to I (30 min)/R (45 min). We …
Protein Kinase C (Pkc) Delta Activation Negatively Regulates Phorbol 12-Myristate 13-Acetate (Pma) Induced Superoxide (So) Release In Polymorphonuclear Leukocytes (Pmns), Stephanie Liu, Stephanie Percy, Samuel Johannson, Christine Adekayode, Gregory Stoner, Amelie Bottex, Jovan Adams, Robert Barsotti, Qian Chen
Protein Kinase C (Pkc) Delta Activation Negatively Regulates Phorbol 12-Myristate 13-Acetate (Pma) Induced Superoxide (So) Release In Polymorphonuclear Leukocytes (Pmns), Stephanie Liu, Stephanie Percy, Samuel Johannson, Christine Adekayode, Gregory Stoner, Amelie Bottex, Jovan Adams, Robert Barsotti, Qian Chen
Research Day
It’s known that PMA is a broad-spectrum PKC activator that augments SO release in PMNs viaNADPH oxidase activation. It was shown that PKC delta (δ) negatively regulates PMN elastase release which suggests that PKC δ may also negatively regulate PMN NADPH oxidase SO release. To test the hypothesis, we altered PKC δ activity using selective cell permeable PKC δ activator, inhibitor peptides, and rottlerin, another type of PKC δ inhibitor. We predict that PKC δ activation would attenuate PMA-induced PMN SO release, whereas PKC δ inhibition would augment the response. Isolated PMNs (5x106) from male Sprague-Dawley rats were incubated in …
Financial Toxicity: A Side Effect Of Radiation Therapy For Cancer?, Tejash Patel, Joshua Palmer, Harriet Eldredge-Hindy, John Smyles, Jessie Dinome, Usha Babaria, Richard Stabile, Eric Gressen, Shari Rudoler, Scot Fisher
Financial Toxicity: A Side Effect Of Radiation Therapy For Cancer?, Tejash Patel, Joshua Palmer, Harriet Eldredge-Hindy, John Smyles, Jessie Dinome, Usha Babaria, Richard Stabile, Eric Gressen, Shari Rudoler, Scot Fisher
Research Day
The field of oncology is ever-changing, as new treatment options become available and treatment plans are unceasingly optimized. While the US remains at the forefront of medical innovation and treatment options for serious and complex conditions such as cancer, costs for cancer care are extremely high and continue to increase. Modern healthcare does not come without a price, and medical expenses can have a profound economic impact on American households. Nearly half of bankruptcy filings are in some way a result of medical expenses. While recent healthcare initiatives have increased access to care, many remain underinsured while facing increasing copayments …
Cadaveric And Chart Retrospective On Shoulder Variation: Morphology And Pain, Jeff Capone, Kerin M. Claeson, Lauren Noto-Bell
Cadaveric And Chart Retrospective On Shoulder Variation: Morphology And Pain, Jeff Capone, Kerin M. Claeson, Lauren Noto-Bell
Research Day
Osteopathic Manipulative Treatment (OMT) is a category of several types of manual techniques used by osteopathic physicians. According to the osteopathic tradition, structure and function are intimately related. This project examined the relationship between shoulder structure and function in an osteopathic framework, with a specific goal to understand how the structure of the acromion affects the development of shoulder injuries. For the first part of this project, cadaveric dissections were performed and muscle diameters were taken of structures within the subacromial space. The second part of this project assessed the efficacy of OMT in shoulder somatic dysfunction for patients treated …