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Role Of Adrenergic Neurons In Motor Control: Examination Of Cerebellar Purkinje Neurons In Mice Following Selective Adrenergic Cell Ablation In Vivo, Monica Mansour

Honors Undergraduate Theses

Phenylethanolamine-N-methyltransferase (Pnmt) is the enzyme that catalyzes the conversion of noradrenaline to adrenaline. These catecholamines are synthesized in the medulla of the adrenal gland and by some neurons of the central nervous system. The precise location of Pnmt action in the brain and its physiological significance are unknown. Prior studies led by Aaron Owji, a graduate student in Dr. Ebert’s laboratory, showed that mice with selectively ablated Pnmt cells show signs of neurological defects such as abnormal gait, weakened grip strength, lack of balance, reduced movement, and defective reflexes during tail suspension tests.

The cerebellum is a small section of …