Life Sciences Commons^™

The Surfactant Dipalmitoylphophatidylcholine (Dppc) Modifies Acute Responses In Alveolar Carcinoma Cells In Response To Low Dose Silver Nanoparticle Exposure, Gordon Chambers, Anna Murphy, Kate Sheehy, Alan Casey

Articles

Nanotechnology is a rapidly growing field with silver nanoparticles (AgNP) in particular utilized in a wide variety of consumer products. This has presented a number of concerns relating to exposure and the associated toxicity to humans and the environment. As inhalation is the most common exposure route, this study investigates the potential toxicity of AgNP to A549 alveolar epithelial carcinoma cells and the influence of a major component of lung surfactant dipalmitoylphosphatidylcholine (DPPC) on toxicity. It was illustrated that exposure to AgNP generated low levels of oxidative stress and a reduction in cell viability. While DPPC produced no significant effect …

The Cosm Newsletter

The COSM Newsletter (2008-2018)

• Laura Regassa, GSTA 2015 Teacher of the Year
• The Department of Biology receives the Kay T. Reissing Terrestrial Snail Collection
• Biology Professor Invited to United Nations Meeting in Rome
• Charles and Sandra Chandler Research Scholarship Program
• Biology Student Kym Coley
• Announcing a New Scholarship in Biology
• Biology Professor coauthors environmental science textbook
• Biology faculty member makes research presentation in Bali, Indonesia
• Chemistry students attend NOBCChE Conference
• Graduate student gives talk at UGA
• Georgia Southern Scientists Map Wassaw Sound
• Graduates go to sea
• Department News
• Student News
• Professor Xiao-Jun Wang appointed as Editor
• Nanotechnology Computational group conducts research
• Updates from the …

Potential Of Biofluid Components To Modify Silver Nanoparticle Toxicity, Gordon Chambers, Anna Murphy, Kate Sheehy, Alan Casey

Articles

Abstract

Establishing realistic exposure scenarios is critical for cytotoxic investigation of silver nanoparticles (AgNP) in the gastrointestinal tract. This study investigated the potential interaction with and effect of biofluid components, namely cholic acid, deoxycholic acid and ursodeoxycholic acid, on AgNP toxicity. Two cell lines corresponding to organs related to the biofluid components were employed. These were HepG-2 a hepatocellular carcinoma derived from liver tissue and Hep2 an epithelial cell line. Physiochemical and cytotoxic screening was performed and the ability of biofluid components to modify AgNP cytotoxicity was explored. No alteration to the physiochemical characteristics of AgNP by biofluid components was …

Social Science Contributions Compared In Synthetic Biology And Nanotechnology, Philip Shapira, Jan Youtie, Yin Li

Philip Shapira

With growing attention to societal issues and implications of synthetic biology, we investigate sources of social science publication knowledge in synthetic biology and probe what might be learned by comparison with earlier rounds of social science research in nanotechnology. “Social science” research is broadly defined to include publications in conventional social science as well as humanities, law, ethics, business, and policy fields. We examine the knowledge clusters underpinning social science publications in nanotechnology and synthetic biology using a methodology based on the analysis of cited references. Our analysis finds that social science research in synthetic biology already has traction and …