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Full-Text Articles in Life Sciences
Replication Of Gene-Gene Interactions In Large Alzheimer Disease Dataset, Kevin Boehme, Dr. John "Keoni" Kauwe
Replication Of Gene-Gene Interactions In Large Alzheimer Disease Dataset, Kevin Boehme, Dr. John "Keoni" Kauwe
Journal of Undergraduate Research
Alzheimer’s disease (AD) is a common and complex neurodegenerative disease. It is the most common cause of dementia and is characterized by the accumulation of amyloid plaques and neurofibrillary tangles. To date, many genetic loci have been found that modify AD risk, but collectively, they explain only a fraction of the heritability of the disease. It is hypothesized that rare variants with large effects as well as epistatic interactions account for much of the unexplained heritability in AD.
Granulins As Inflammatory Mediators In Alzheimer Disease, Randi G. Reed
Granulins As Inflammatory Mediators In Alzheimer Disease, Randi G. Reed
Honors Theses
Alzheimer disease (AD) is a neurodegenerative disorder characterized by severe memory deficit and cognitive decline among the elderly. This degeneration is caused by the aggregation and deposition of a protein called amyloid-β (Aβ) in the brain. Aggregation of Aβ causes neuroinflammation in addition to other toxic events. However, it is unclear whether inflammation from an external source, such as from a traumatic brain injury (TBI), could trigger Aβ aggregation. In this context, several pro-inflammatory mediators such as cytokines and chemokines have been suspects. It is now hypothesized that a group of proteins called granulins (Grns) are unique inflammatory mediators that …