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Full-Text Articles in Life Sciences
Biological Impact Of Feeding Rats With A Genetically Modified-Based Diet, Hanaa Oraby, Mahrousa Kandil, Nermeen Shaffie, Inas Ghaly
Biological Impact Of Feeding Rats With A Genetically Modified-Based Diet, Hanaa Oraby, Mahrousa Kandil, Nermeen Shaffie, Inas Ghaly
Turkish Journal of Biology
This work was conducted in the context of postmarketing biosafety assessment of genetically modified products. It presents a systematic approach based on a chronic toxicity study on Wistar albino rats, with a range of combined parameters including biochemical, histopathological, and cytogenetic to evaluate the negative impact of a genetically modified (GM) diet on animal health. Histopathological and biochemical analysis procedures were performed in the liver, kidney, and testis. Cytogenetic analysis was evaluated in germ cells and the liver. The results revealed that the laboratory diet used in our investigation was proved experimentally, using the PCR assay, to contain genetically modified …
Genotoxicity Of Metaphase-Arresting Methods In Barley, Aslihan Temel, Nermi̇n Gözükirmizi
Genotoxicity Of Metaphase-Arresting Methods In Barley, Aslihan Temel, Nermi̇n Gözükirmizi
Turkish Journal of Biology
Amiprophos-methyl (APM) and colchicine (COL) are therapeutic agents and are also used in plant science. Cell cycle synchronization (CCS) is mediated by hydroxyurea (HU) and APM. The genotoxic effects of APM are unclear. In order to assess the genotoxicity of APM separately and with HU and then compare it with COL, we treated 2-day-old barley (Hordeum vulgare 'Bornova-92') seedlings with 8 µM APM for 2 h, 1.25 mM COL for 18 h, or 1.25 mM HU for 18 h and 4 µM APM for 2 h, with a final ice-cold water incubation. Following treatment, seedlings were recovered without any substance …