Life Sciences Commons^™

Effects Of Bariatric Surgery On Adipokine-Induced Inflammation And Insulin Resistance, Zeynep Goktas, Naima Moustaid-Moussa, Chwan-Li Shen, Mallory Boylan, Huanbiao Mo, Shu Wang

Nutrition Faculty Publications

Over a third of the US population is obese and at high risk for developing type 2 diabetes, insulin resistance, and other metabolic disorders. Obesity is considered a chronic lowgrade inflammatory condition that is primarily attributed to expansion and inflammation of adipose tissues. Indeed, adipocytes produce and secrete numerous proinflammatory and anti-inflammatory cytokines known as adipokines.When the balance of these adipokines is shifted toward higher production of proinflammatory factors, local inflammation within adipose tissues and subsequently systemic inflammation occur. These adipokines including leptin, visfatin, resistin, apelin, vaspin, and retinol binding protein-4 can regulate inflammatory responses and contribute to the pathogenesis …