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- Flavivirus replication; nonstructural proteins; nonstructural protein interactions; cis-acting RNA sequences; conserved RNA structures; host factors; RNA-protein interactions; host cell remodeling (1)
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Articles 1 - 16 of 16
Full-Text Articles in Life Sciences
Replication Cycle And Molecular Biology Of The West Nile Virus, Margo A. Brinton
Replication Cycle And Molecular Biology Of The West Nile Virus, Margo A. Brinton
Biology Faculty Publications
West Nile virus (WNV) is a member of the genus Flavivirus in the family Flaviviridae. Flaviviruses replicate in the cytoplasm of infected cells and modify the host cell environment. Although much has been learned about virion structure and virion-endosomal membrane fusion, the cell receptor(s) used have not been definitively identified and little is known about the early stages of the virus replication cycle. Members of the genus Flavivirus differ from members of the two other genera of the family by the lack of a genomic internal ribosomal entry sequence and the creation of invaginations in the ER membrane rather than …
Nitric Oxide Regulates Neuronal Activity Via Calcium- Activated Potassium Channels, Lei Ray Zhong, Stephen Estes, Liana Artinian, Vincent Rehder
Nitric Oxide Regulates Neuronal Activity Via Calcium- Activated Potassium Channels, Lei Ray Zhong, Stephen Estes, Liana Artinian, Vincent Rehder
Biology Faculty Publications
Nitric oxide (NO) is an unconventional membrane-permeable messenger molecule that has been shown to play various roles in the nervous system. How NO modulates ion channels to affect neuronal functions is not well understood. In gastropods, NO has been implicated in regulating the feeding motor program. The buccal motoneuron, B19, of the freshwater pond snail Helisoma trivolvis is active during the hyper-retraction phase of the feeding motor program and is located in the vicinity of NO-producing neurons in the buccal ganglion. Here, we asked whether B19 neurons might serve as direct targets of NO signaling. Previous work established NO as …
Selective G-Quadruplex Dna Recognition By A New Class Of Designed Cyanines, Rupesh Nanjunda, Eric A. Owens, Leah E. Mickelson, Tyler L. Dost, Ekaterina M. Stroeva, Hang T. Huynh, Markus W. Germann, Maged M. Henary, W. David Wilson
Selective G-Quadruplex Dna Recognition By A New Class Of Designed Cyanines, Rupesh Nanjunda, Eric A. Owens, Leah E. Mickelson, Tyler L. Dost, Ekaterina M. Stroeva, Hang T. Huynh, Markus W. Germann, Maged M. Henary, W. David Wilson
Biology Faculty Publications
A variety of cyanines provide versatile and sensitive agents acting as DNA stains and sensors and have been structurally modified to bind in the DNA minor groove in a sequence dependent manner. Similarly, we are developing a new set of cyanines that have been designed to achieve highly selective binding to DNA G-quadruplexes with much weaker binding to DNA duplexes. A systematic set of structurally analogous trimethine cyanines has been synthesized and evaluated for quadruplex targeting. The results reveal that elevated quadruplex binding and specificity are highly sensitive to the polymethine chain length, heterocyclic structure and intrinsic charge of the …
‘Clustering’ Sirpα Into The Plasma Membrane Lipid Microdomains Is Required For Activated Monocytes And Macrophages To Mediate Effective Cell Surface Interactions With Cd47, Binh Ha, Zhiyuan Lv, Zhen Bian, Xiugen Zhang, Aarti Mishra, Yuan Liu
‘Clustering’ Sirpα Into The Plasma Membrane Lipid Microdomains Is Required For Activated Monocytes And Macrophages To Mediate Effective Cell Surface Interactions With Cd47, Binh Ha, Zhiyuan Lv, Zhen Bian, Xiugen Zhang, Aarti Mishra, Yuan Liu
Biology Faculty Publications
SIRPα, an ITIMs-containing signaling receptor, negatively regulates leukocyte responses through extracellular interactions with CD47. However, the dynamics of SIRPα-CD47 interactions on the cell surface and the governing mechanisms remain unclear. Here we report that while the purified SIRPα binds to CD47 and that SIRPα is expressed on monocytes and monocytic THP-1 or U937, these SIRPα are ineffective to mediate cell binding to immobilized CD47. However, cell binding to CD47 is significantly enhanced when monocytes transmigrating across endothelia, or being differentiated into macrophages. Cell surface labeling reveals SIRPα to be diffused on naïve monocytes but highly clustered on transmigrated monocytes and …
Activation Of High And Low Affinity Dopamine Receptors Generates A Closed Loop That Maintains A Conductance Ratio And Its Activity Correlate, Wulf-Dieter C. Krenz, Ryan M. Hooper, Anna R. Parker, Astrid A. Prinz, Deborah J. Baro
Activation Of High And Low Affinity Dopamine Receptors Generates A Closed Loop That Maintains A Conductance Ratio And Its Activity Correlate, Wulf-Dieter C. Krenz, Ryan M. Hooper, Anna R. Parker, Astrid A. Prinz, Deborah J. Baro
Biology Faculty Publications
Neuromodulators alter network output and have the potential to destabilize a circuit. The mechanisms maintaining stability in the face of neuromodulation are not well described. Using the pyloric network in the crustacean stomatogastric nervous system, we show that dopamine (DA) does not simply alter circuit output, but activates a closed loop in which DA-induced alterations in circuit output consequently drive a change in an ionic conductance to preserve a conductance ratio and its activity correlate. DA acted at low affinity type 1 receptors (D1Rs) to induce an immediate modulatory decrease in the transient potassium current (I A ) of a …
Lactobacillus Plantarum Dk119 As A Probiotic Confers Protection Against Influenza Virus By Modulating Innate Immunity, Min-Kyung Park, Vu Ngo, Young-Man Kwon, Young-Tae Lee, Sieun Yoo, Young-Hee Choo, Sung-Moon Hong, Hye Suk Hwang, Eun-Ju Ko, Yu-Jin Jung, Dae-Won Moon, Eun-Ji Jeong, Min-Chul Kim, Yu-Na Lee, Ji-Hun Jang, Joon-Suk Oh, Cheol-Hyun Kim, Sang-Moon Kang
Lactobacillus Plantarum Dk119 As A Probiotic Confers Protection Against Influenza Virus By Modulating Innate Immunity, Min-Kyung Park, Vu Ngo, Young-Man Kwon, Young-Tae Lee, Sieun Yoo, Young-Hee Choo, Sung-Moon Hong, Hye Suk Hwang, Eun-Ju Ko, Yu-Jin Jung, Dae-Won Moon, Eun-Ji Jeong, Min-Chul Kim, Yu-Na Lee, Ji-Hun Jang, Joon-Suk Oh, Cheol-Hyun Kim, Sang-Moon Kang
Biology Faculty Publications
Lactobacillus plantarum DK119 (DK119) isolated from the fermented Korean cabbage food was used as a probiotic to determine its antiviral effects on influenza virus. DK119 intranasal or oral administration conferred 100% protection against subsequent lethal infection with influenza A viruses, prevented significant weight loss, and lowered lung viral loads in a mouse model. The antiviral protective efficacy was observed in a dose and route dependent manner of DK119 administration. Mice that were treated with DK119 showed high levels of cytokines IL-12 and IFN-c in bronchoalveolar lavage fluids, and a low degree of inflammation upon infection with influenza virus. Depletion of …
The Effects Of Blocking Hippocampal Acetylcholine On Meal Onset In Male Rats, Jasmine Nicole Gentry
The Effects Of Blocking Hippocampal Acetylcholine On Meal Onset In Male Rats, Jasmine Nicole Gentry
Georgia State Undergraduate Research Conference
No abstract provided.
Outcrossing And Phenotypic Analysis Of A Hlh-25 Mutant, Emma K. Blasingame
Outcrossing And Phenotypic Analysis Of A Hlh-25 Mutant, Emma K. Blasingame
Georgia State Undergraduate Research Conference
No abstract provided.
Cloning And Initial Characterization Of A Likely Heme Binding Protein From Group B Streptococci, Darius J. Devlin
Cloning And Initial Characterization Of A Likely Heme Binding Protein From Group B Streptococci, Darius J. Devlin
Georgia State Undergraduate Research Conference
No abstract provided.
Daily Variation In Ctenophore Abundance During Summer 2012 In The Long Term Skidaway River Monitoring Program (Srimp) Site, Mariya Campbell
Daily Variation In Ctenophore Abundance During Summer 2012 In The Long Term Skidaway River Monitoring Program (Srimp) Site, Mariya Campbell
Georgia State Undergraduate Research Conference
No abstract provided.
Dual Role Of The Metalloprotease Ftsh In Biogenesis Of The Drrab Drug Transporter, Wen Li, Divya Kishore Rao, Parjit Kaur
Dual Role Of The Metalloprotease Ftsh In Biogenesis Of The Drrab Drug Transporter, Wen Li, Divya Kishore Rao, Parjit Kaur
Biology Faculty Publications
This study provides the first direct evidence for the dual role of the metalloprotease FtsH in membrane protein biogenesis. Using the physiological substrate DrrAB, it is shown that FtsH is not only responsible for proteolysis of unassembled DrrB protein but it also plays a much broader role in biogenesis of the DrrAB complex. Previous studies showed that the stable expression of DrrB in the membrane depends on simultaneous expression of DrrA. Here we show that DrrB is proteolyzed by FtsH when it is expressed alone. Moreover, DrrA and DrrB proteins expressed together in a temp-sensitive ftsH mutant strain of E. …
Genome-Wide Microarrray Analysis Reveals Roles For The Ref-1 Family Member Hlh-29 In Ferritin Synthesis And Peroxide Stress Response, Tam Quach, Han Ting Chou, Kun Wang, Gaolin Zheng Milledge, Casonya Johnson
Genome-Wide Microarrray Analysis Reveals Roles For The Ref-1 Family Member Hlh-29 In Ferritin Synthesis And Peroxide Stress Response, Tam Quach, Han Ting Chou, Kun Wang, Gaolin Zheng Milledge, Casonya Johnson
Biology Faculty Publications
In Caenorhabditis elegans, the six proteins that make up the REF-1 family have been identified as functional homologs of the Hairy/Enhancer of Split (HES) proteins. These transcription factors act in both Notch dependent and Notch-independent pathways to regulate embryonic events during development; however, their post-embryonic functions are not well defined. As a first step toward understanding how the REF-1 family works together to coordinate post-embryonic events, we used gene expression microarray analysis to identify transcriptional targets of HLH-29 in L4/young adult stage animals. Here we show that HLH-29 targets are genes needed for the regulation of growth and lifespan, including …
Do Viruses Require The Cytoskeleton?, Jason D. Matthews, Rachel Morgan, Christie Sleigher, Teryl K. Frey
Do Viruses Require The Cytoskeleton?, Jason D. Matthews, Rachel Morgan, Christie Sleigher, Teryl K. Frey
Biology Faculty Publications
Background: It is generally thought that viruses require the cytoskeleton during their replication cycle. However, recent experiments in our laboratory with rubella virus, a member of the family Togaviridae (genus rubivirus), revealed that replication proceeded in the presence of drugs that inhibit microtubules. This study was done to expand on this observation.
Findings: The replication of three diverse viruses, Sindbis virus (SINV; family Togaviridae family), vesicular stomatitis virus (VSV; family Rhabdoviridae), and Herpes simplex virus (family Herpesviridae), was quantified by the titer (plaque forming units/ml; pfu/ml) produced in cells treated with one of three anti-microtubule drugs (colchicine, noscapine, or paclitaxel) …
Redox-Sensitive Dna Binding By Homodimeric Methanosarcina Acetivorans Msvr Is Modulated By Cysteine Residues, Catherine E. Isom, Jessica Turner, Daniel J. Lessner, Elizabeth A. Karr
Redox-Sensitive Dna Binding By Homodimeric Methanosarcina Acetivorans Msvr Is Modulated By Cysteine Residues, Catherine E. Isom, Jessica Turner, Daniel J. Lessner, Elizabeth A. Karr
Biology Faculty Publications
Background: Methanoarchaea are among the strictest known anaerobes, yet they can survive exposure to oxygen. The mechanisms by which they sense and respond to oxidizing conditions are unknown. MsvR is a transcription regulatory protein unique to the methanoarchaea. Initially identified and characterized in the methanogen Methanothermobacter thermautotrophicus (Mth), MthMsvR displays differential DNA binding under either oxidizing or reducing conditions. Since MthMsvR regulates a potential oxidative stress operon in M. thermautotrophicus, it was hypothesized that the MsvR family of proteins were redox-sensitive transcription regulators.
Results: An MsvR homologue from the methanogen Methanosarcina acetivorans, MaMsvR, was overexpressed and purified. The two MsvR …
Turning T Cells On: Epigenetically Enhanced Expression Of Effector T-Cell Costimulatory Molecules On Irradiated Human Tumor Cells, Anita Kumari, Ercan Cacun, Susanna F. Greer, Charlie Garnett-Benson
Turning T Cells On: Epigenetically Enhanced Expression Of Effector T-Cell Costimulatory Molecules On Irradiated Human Tumor Cells, Anita Kumari, Ercan Cacun, Susanna F. Greer, Charlie Garnett-Benson
Biology Faculty Publications
Background: Sub-lethal doses of radiation can alter the phenotype of target tissue by modulating gene expression and making tumor cells more susceptible to T-cell-mediated immune attack. We have previously shown that sublethal tumor cell irradiation enhances killing of colorectal carcinoma cells by tumor-specific cytotoxic T cells by unknown mechanisms. Recent data from our lab indicates that irradiation of tumor cells results in the upregulation of OX40L and 41BBL, and that T cells incubated with irradiated tumor cells displayed improved CTL survival, activation and effector activity. The objective of this current study was to determine the mechanism of enhanced OX40L and …
Cross-Modal Plasticity Results In Increased Inhibition In Primary Auditory Cortical Areas, Yuting Mao, Sarah L. Pallas
Cross-Modal Plasticity Results In Increased Inhibition In Primary Auditory Cortical Areas, Yuting Mao, Sarah L. Pallas
Biology Faculty Publications
Loss of sensory input from peripheral organ damage, sensory deprivation, or brain damage can result in adaptive or maladaptive changes in sensory cortex. In previous research, we found that auditory cortical tuning and tonotopy were impaired by cross-modal invasion of visual inputs. Sensory deprivation is typically associated with a loss of inhibition. To determine whether inhibitory plasticity is responsible for this process, we measured pre- and postsynaptic changes in inhibitory connectivity in ferret auditory cortex (AC) after cross-modal plasticity.We found that blocking GABAA receptors increased responsiveness and broadened sound frequency tuning in the cross-modal group more than in the normal …