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Articles 31 - 32 of 32
Full-Text Articles in Life Sciences
Hepatitis C Virus Core And Nonstructural Protein 3 Proteins Induce Pro- And Anti-Inflammatory Cytokines And Inhibit Dendritic Cell Differentiation, Angela Dolganiuc, Karen Kodys, Andrea Kopasz, Christopher Marshall, Twan Do, Laszlo Romics, Pranoti Mandrekar, Maria Zapp, Gyongyi Szabo
Hepatitis C Virus Core And Nonstructural Protein 3 Proteins Induce Pro- And Anti-Inflammatory Cytokines And Inhibit Dendritic Cell Differentiation, Angela Dolganiuc, Karen Kodys, Andrea Kopasz, Christopher Marshall, Twan Do, Laszlo Romics, Pranoti Mandrekar, Maria Zapp, Gyongyi Szabo
Gyongyi Szabo
Antiviral immunity requires recognition of viral pathogens and activation of cytotoxic and Th cells by innate immune cells. In this study, we demonstrate that hepatitis C virus (HCV) core and nonstructural protein 3 (NS3), but not envelope 2 proteins (E2), activate monocytes and myeloid dendritic cells (DCs) and partially reproduce abnormalities found in chronic HCV infection. HCV core or NS3 (not E2) triggered inflammatory cytokine mRNA and TNF-alpha production in monocytes. Degradation of I-kappa B alpha suggested involvement of NF-kappa B activation. HCV core and NS3 induced production of the anti-inflammatory cytokine, IL-10. Both monocyte TNF-alpha and IL-10 levels were …
Differential Endocytosis Of Tissue Plasminogen Activator By Serpins Pai-1 And Pai-2 On Human Peripheral Blood Monocytes, Jodi A. Lee, David Croucher, Marie Ranson
Differential Endocytosis Of Tissue Plasminogen Activator By Serpins Pai-1 And Pai-2 On Human Peripheral Blood Monocytes, Jodi A. Lee, David Croucher, Marie Ranson
Faculty of Science - Papers (Archive)
Generation of the broad spectrum protease plasmin is facilitated by the tissue (t-PA) and urokinase (u-PA) plasminogen activators, within multiple physiological and disease states. Finely tuned control of this proteolytic cascade is exerted by the plasminogen activator inhibitors type-1 (PAI-1/SERPINE1) and 2 (PAI-2/SERPINB2). Expression of this network of activators and inhibitors by cells of myeloid lineage appears to be highly interchangeable between physiological environments, and whilst the role of PAI-1 and PAI-2 in regulating u-PA-dependent functions is well established, the interaction between t-PA and PAI-2 on these cell types is poorly characterised. To this end, we used freshly isolated peripheral …