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Applications Of Variable Number Tandem Repeat Genotyping In The Validation Of An Animal Medical Model And Gene Flow Studies In Threatened Populations Of Reptiles, Candace D. Smith Dec 2009

Applications Of Variable Number Tandem Repeat Genotyping In The Validation Of An Animal Medical Model And Gene Flow Studies In Threatened Populations Of Reptiles, Candace D. Smith

Graduate Theses and Dissertations

We used variable number tandem repeats (VNTR) to validate the chicken as a human medical model for Pulmonary Arterial Hypertension. We identified seven regions on four chromosomes and interrogated for VNTR markers that significantly associate with Pulmonary Hypertension Syndrome/ascites. In those regions, we identified 7 candidate genes; AGTR1, ACE, p38MAPK, SST, 5HT2B, NET1, and CALM3 for further analysis as significantly contributing QTL for ascites/PHS. We also used variable number tandem repeats to measure gene flow and gather evidence for multiple paternity in a population of Timber rattlesnakes, Crotalus horridus. We were able to verify 1 VNTR that can be used …


Evolution And Maintenance Of Plumage Polymorphism: The Case Of The Red-Footed Booby (Sula Sula), Patricia Carvalho Baiao Jul 2009

Evolution And Maintenance Of Plumage Polymorphism: The Case Of The Red-Footed Booby (Sula Sula), Patricia Carvalho Baiao

Dissertations

The red-footed booby (Sula sula) is considered one of the most polymorphic seabirds, with three recognized major adult plumage types: (1) white; (2) white-tailed brown; and (3) brown, and several degrees of intermediates. The ratio of these color morphs varies among populations, with the white morph typically predominating. However, there are a few populations that present an inversed ratio of color morphs, such as Isla Europa in the Indian Ocean and the Galapagos archipelago, with the white-tailed brown or brown morphs predominating. I studied natural populations of red-footed boobies from three geographic locations, namely, the Galapagos archipelago, Johnston Atoll in …