Open Access. Powered by Scholars. Published by Universities.®
- Keyword
- Publication Type
Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
Opening Remarks, Jay Cox
Eco-Connections, Margaret Costello
Caenorhabditis Elegans Atx-2 Promotes Germline Proliferation And The Oocyte Fate, Eleanor M. Maine, Dave Hansen, Deborah Springer, Valarie E. Vought
Caenorhabditis Elegans Atx-2 Promotes Germline Proliferation And The Oocyte Fate, Eleanor M. Maine, Dave Hansen, Deborah Springer, Valarie E. Vought
Biology - All Scholarship
In the Caenorhabditis elegans germline, proliferation is induced by Notch-type signaling. Entry of germ cells into meiosis is triggered by activity of the GLD-1 and GLD-2 pathways, which function redundantly to promote meiosis and/or inhibit proliferation. Activation of the germline Notch-type receptor, GLP-1, ultimately inhibits the activities of the GLD-1 and GLD-2 pathways. We previously identified several ego (enhancer of glp-1) genes that promote germline proliferation and interact genetically with the GLP-1 signaling pathway. Here, we show that atx-2 is an ego gene. Our data suggest that ATX-2 is not a positive regulator of the GLP-1 signaling pathway and GLP-1 …