Life Sciences Commons^™

Morphogenesis Is Coordinated With Nuclear Division In Germinating Aspergillus Nidulans Conidiospores, Steven D. Harris

Department of Plant Pathology: Faculty Publications

Germinating Aspergillus nidulans conidiospores switch to polarized apical growth following an initial period of isotropic expansion. At the same time, they re-enter the nuclear division cycle. The relationship between spore polarization and nuclear division was investigated by testing the effect of cell cycle inhibitors and temperature-sensitive cell cycle mutations on spore morphogenesis. On rich media, it was found that spore polarization is delayed if completion of the first mitosis is blocked. The observed delay may be dependent upon the activity of the mitosis-promoting NIMA kinase. An additional mechanism appears to prevent polarization as the spore progresses through its first S …

Cell Cycle-Dependent Sequencing Of Cell Fate Decisions In Caenorhabditis Elegans Vulva Precursor Cells, Victor Ambros

Dartmouth Scholarship

In Caenorhabditis elegans, the fates of the six multipotent vulva precursor cells (VPCs) are specified by extracellular signals. One VPC expresses the primary (1°) fate in response to a Ras-mediated inductive signal from the gonad. The two VPCs flanking the 1° cell each express secondary (2°) fates in response to lin-12-mediated lateral signaling. The remaining three VPCs each adopt the non- vulval tertiary (3°) fate. Here I describe experiments examining how the selection of these vulval fates is affected by cell cycle arrest and cell cycle-restricted lin-12 activity. The results suggest that lin-12 participates in two

INTRODUCTION

Cell-cell signaling is …

Effects Of Cytokines On Cell Cycle, Hati̇ce Güneş

Turkish Journal of Biology

Cytokines are cellular regulatory proteins. They are secreted by specific cells, which are activated by certain stimuli, in different tissues. Cytokines control numerous biological functions and one of their important effects is on cell division. Although some of the cytokines have a positive effect on the cell cycle, some play a negative role. The positive and negative effects of cytokines depend upon the cell type. In this paper, the moleculer mechanisms of cytokine effects on the cell cycle are examined.