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Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
Development Of An In Vitro Assay To Predict Patient Response To Radiotheraphy, Mary Sheridan
Development Of An In Vitro Assay To Predict Patient Response To Radiotheraphy, Mary Sheridan
Doctoral
At the present time, the treatment plan for a patient with cancer is usually based on parameters such as tumour site, histological type, and tumour stage and performance status. However, it is well know that the radiosensitivity of human cancers varies widely from one patient to another (Fertil et al., 1981), and that even within these broad categories some tumours will show greater response to radiotherapy than others. If those patients unlikely to be cured by radiotherapy could be identified prior to commencement of treatment, alternative or more aggressive therapies might be selected which may give a better chance of …
Identification And Characterization Of Genes Associated With V-Jun Induced Cell Transformation, Martin Toralballa Hadman
Identification And Characterization Of Genes Associated With V-Jun Induced Cell Transformation, Martin Toralballa Hadman
Biological Sciences Theses & Dissertations
The v-jun oncogene was initially identified as the causative agent for fibrosarcomas in chickens. Studies show that overexpression of v-Jun proteins transforms chicken embryo fibroblasts (CEF) in vitro, and forms tumors in chickens in vivo. The mechanisms for this are not clearly defined. Conceivably, overexpression of an unregulated transcription factor would cause cell transfonnation by illicit regulation of its target genes. In support of this, we show that in vivo v-Jun complexes exhibit differential binding to in vitro generated AP-1 and 'AP-1 like' target sequences, suggesting that the pattern of target gene expression is altered during cell transformation. …
Gold, Electron Microscopy, And Cancer Therapy, James F. Hainfeld
Gold, Electron Microscopy, And Cancer Therapy, James F. Hainfeld
Scanning Microscopy
Radioactive gold has properties suitable for radiotherapy and can provide lethal irradiation to cells. If the gold is conjugated to a targeting molecule, such as an antibody, it may be possible to specifically deliver the dose to tumor cells. Various gold particles are possible candidates and include gold colloids with adsorption of antibodies or gold clusters with covalent attachment. Different sizes of gold particles are available and some may be preferred for certain situations. Problems with intravenous injection and in vivo delivery are numerous, and a more tractable application is the direct instillation into the urinary bladder of radiogold immunoconjugates …
Perceived Risks Of Emfs And Landowner Compensation, Linda J. Orel
Perceived Risks Of Emfs And Landowner Compensation, Linda J. Orel
RISK: Health, Safety & Environment (1990-2002)
Although public concerns about EMFs may eventually prove groundless, they can nevertheless depress the market value of residential property near powerlines. Ms. Orel argues that the scientific truth, as courts increasingly recognize, should play no role in determining whether or how much landowners should recover.
A Survey Of Residual Cancer Risks Permitted By Health, Safety And Environmental Policy, March Sadowitz, John D. Graham
A Survey Of Residual Cancer Risks Permitted By Health, Safety And Environmental Policy, March Sadowitz, John D. Graham
RISK: Health, Safety & Environment (1990-2002)
The authors describe permitted U.S. residual cancer risks, focusing on numerical levels specifically and implicitly authorized by statute or regulation. They also discuss potential changes.