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Full-Text Articles in Life Sciences
Estrogen Induced Eosinophil Migration Into The August Rat Uterus Is Associated With Intercellular Adhesion Molecule Expression, Daniel R. Orcutt
Estrogen Induced Eosinophil Migration Into The August Rat Uterus Is Associated With Intercellular Adhesion Molecule Expression, Daniel R. Orcutt
Masters Theses
Estrogen causes an influx of eosinophils into the uterus in female rats. The diapedesis of eosinophils out of the vasculature has also been observed in allergic reactions, parasitic infections, and atopic dermatitis, and has been associated with cellular adhesion molecules (CAMs). Antibody blocking studies against ICAM-1/ LFA-1 and VCAM-1/VLA-4 have suggested that both ligand/receptor sets of CAMs are involved in the selective recruitment of eosinophils out of the vasculature. ICAM- 1 is expressed on the vascular endothelium and decreases in expression when IL-4 is introduced. VLA-4 is present on eosinophils and is suspected to allow selective migration of eosinophils out …
Expression Of Integrated And Methylated Hiv-Ltr In Human T-Cells And Monkey Kidney Cells By Frog Virus 3 Infection, Celene M. Spangler
Expression Of Integrated And Methylated Hiv-Ltr In Human T-Cells And Monkey Kidney Cells By Frog Virus 3 Infection, Celene M. Spangler
Masters Theses
DNA methylation has been implicated in the suppression of transcription of a large spectrum of eukaryotic genes. Frog virus 3 (FV3) contains genomic DNA that is the most extensively methylated of all known animal viruses. However, FV3 gene expression is tightly regulated in a sequential fashion in infected cells. Therefore, FV3 must have evolved mechanism(s) to overcome the inhibitory effects of DNA methylation. FV3 has been shown to induce expression of methylated foreign genes in transient transfections. This study was designed to establish if this FV3 induced expression of methylated genes could be demonstrated in stable cell lines which contain …
The Effect Of Insulin Mimetics On Enzymes Of Fatty Acid Biosynthesis, Eric A. Berg
The Effect Of Insulin Mimetics On Enzymes Of Fatty Acid Biosynthesis, Eric A. Berg
Masters Theses
Fatty acid biosynthesis, an insulin regulated pathway, is the process of producing fatty acid chains from 2 and 3 carbon units. Two enzymes in this pathway that insulin affects are glucose-6-phosphate dehydrogenase (G6PDH) and fatty acid synthase (FAS). Sodium vanadate and sodium selenate have demonstrated insulin-like effects in several tissue and cell types. These mimetic effects include increasing glucose transport, regulating glycolytic enzymes, normalizing plasma glucose levels and activities of insulin regulated enzymes in diabetic rats. Our goal was to examine effects of sodium vanadate and sodium selenate on fatty acid biosynthesis in two insulin responsive systems: Isolated rat hepatocytes …