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The Hippocampus As Episodic Encoder: Does It Play Tag?, Robert H.I. Dale Sep 1985

The Hippocampus As Episodic Encoder: Does It Play Tag?, Robert H.I. Dale

Scholarship and Professional Work - LAS

Rawlins’s characterization of the hippocampus as a “high-capacity, immediate-term memory store” captures the essential idea in a number of previous models. For example, Gaffan (1974), Gray (1984), Hirsh (1980), Kesner (Bierley, Kesner & Novak 1983), Olton (Olton, Becker & Handelmann 1979), Solomon (1980), and Winocur (1980) all agree that hippocampal animals show memory deficits when required to identify, for whatever reason, one specific event out of a list of recent events. Although these authors disagree on a number of details, Rawlins has identified their models common ground, the core of each model. (It is only fair to note that Gaffan …


The Effect Of High Energy (Hze) Particle Radiation (40ar) On Aging Parameters Of Mouse Hippocampus And Retina, D. E. Philpott, W. Sapp, J. Miquel, K. Kato, R. Corbett, J. Stevenson, S. Black, K. A. Lindseth, E. V. Benton Jul 1985

The Effect Of High Energy (Hze) Particle Radiation (40ar) On Aging Parameters Of Mouse Hippocampus And Retina, D. E. Philpott, W. Sapp, J. Miquel, K. Kato, R. Corbett, J. Stevenson, S. Black, K. A. Lindseth, E. V. Benton

Scanning Electron Microscopy

Eight month old C57BL6 mice were exposed (head only) to 0.5 rad or 50 rads of Argon particles at the Lawrence Berkeley Radiation Facility, CA. Neuromotor performance was assessed monthly for six months beginning twelve weeks post-irradiation using a ''string test". The decline in motor performance was dose-related and none of the animals was able to complete the task after four months of testing. Morphological changes were monitored six and twelve months post-irradiation by light and electron microscopy. The synaptic density in the CA-1 area of the hippocampus decreased six and twelve months after irradiation. The decrease after twelve months …