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Renin Granularity In The Mouse Kidney, R. Williams Soller

Senior Scholar Papers

Briefly. the rennin-angiotensin-aldosterone triangle can be thou ht of as a regulator of renal perfusion. Renin, released by the kidney in response to any threat in its perfusion n, acts on its substrate to produce angiotensin I, a mild vasoconstrictor which by means of plasma converting enzymes secretes angiotensint II. This latter product not only stimulates aldosterone output by the adrenals, but also supports the animals’ blood pressure. With aldosterone binding at the distal tubules in the kidney and this causing increased sodium retention, restoration of renal perfusion occurs – a phenomenon which shuts off the original signal for rennin …