Life Sciences Commons^™

Bridging The Translational Gap Between Rodent And Human Pain Research, Tayler Diane Sheahan

Arts & Sciences Electronic Theses and Dissertations

The treatment of chronic pain is an immense clinical and societal burden rooted in the ineffectiveness and adverse side effects of existing analgesics. Extensive efforts have been directed towards the development of novel pain therapies with maximal efficacy and minimal unwanted effects; however, putative therapeutic targets identified in preclinical rodent models rarely translate in clinical trials. The poor translational record of basic pain research findings has been attributed, in part, to the use of suboptimal rodent pain models and behavioral endpoints used to assess putative analgesics, as well as differences in the pharmacological profiles of rodents and humans. The work …

An Examination Of The Influence Of Social Physique Anxiety On Effort And Exercise Participation In College Students, Trellony M. Irwin

Honors Theses

The purpose of this study was to investigate whether an individual’s perception of others influenced exercise participation and effort in women and men participants involved in exercise classes in a campus recreation facility. The study consists of a survey that utilizes the Social Physique Anxiety Scale, the Ratings of Perceived Exertion (RPE) Scale, and demographic information. Results revealed that participants’ social physique anxiety accounted for roughly 30% of the variance in self-reported physical activity. However, when it came to participant effort during the group exercise classes, there was only roughly 2% variance between social physique anxiety and RPE. Further, the …

Pharmaceutical And Natural (Exercise) Mechanisms To Mitigate The Negative Impact Of Ptsd And Chronic Stress On Synaptic Plasticity And Memory, Roxanne M. Miller

Theses and Dissertations

Synapses can be altered due to experiences in a process called synaptic plasticity, which causes memory formations. Synapses can be strengthened through methods known as long-term potentiation (LTP) or weakened through long-term depression (LTD). Stresses can cause changes by altering synapses through either LTP or LTD. Rats were used to study the effects of post-traumatic stress disorder (PTSD)-like symptoms and a prophylactic treatment using pharmaceuticals. The first model used was the single prolonged stress (SPS) with two weeks of chronic light, which was not as effective for causing changes in synaptic plasticity. The second model, seven days of social defeat …

Pharmaceutical And Natural (Exercise) Mechanisms To Mitigate The Negative Impact Of Ptsd And Chronic Stress On Synaptic Plasticity And Memory, Roxanne M. Miller

Theses and Dissertations

Synapses can be altered due to experiences in a process called synaptic plasticity, which causes memory formations. Synapses can be strengthened through methods known as long-term potentiation (LTP) or weakened through long-term depression (LTD). Stresses can cause changes by altering synapses through either LTP or LTD. Rats were used to study the effects of post-traumatic stress disorder (PTSD)-like symptoms and a prophylactic treatment using pharmaceuticals. The first model used was the single prolonged stress (SPS) with two weeks of chronic light, which was not as effective for causing changes in synaptic plasticity. The second model, seven days of social defeat …

Physical Activity And Associated Energy Intake In Undergraduate College Students, Erin Marie Fejes

Theses and Dissertations

Background: College students often develop unhealthy eating habits. Poor eating habits can lead to chronic disease.

Methods: Energy intake and physical activity data from 35 undergraduate students enrolled in a 100-level kinesiology class were recorded and analyzed. Energy intake data was self-reported, while physical activity data was recorded via an activity tracker.

Results: Data points were analyzed twice: each day separately and as averages for each participant. When analyzed as averages, grams of total fat and grams of carbohydrate were the most significantly correlated with minutes of moderate to vigorous+ physical activity (both p<0.01). When analyzed by day, grams of protein, total fat, saturated fat, carbohydrate, sugar, and fiber were all found to be significantly correlated with minutes of moderate to vigorous physical activity to the p≤0.01 level.

Conclusion: An increase in physical activity …

Insulin Resistance And T1d: The Effect Of Exercise On Skeletal Muscle Lipid Metabolism, Michelle Dotzert

Electronic Thesis and Dissertation Repository

Insulin resistance is a characteristic of Type 2 Diabetes (T2D) and metabolic syndrome, and until recently has not been considered in the context of Type 1 Diabetes (T1D). A new classification, Double Diabetes, encompasses the presence of insulin resistance in T1D. Unfortunately, these individuals are at significantly higher risk of cardiovascular complications than those with T1D alone. In T2D, abnormal skeletal muscle lipid metabolism and the accumulation of insulin desensitizing lipid metabolites contribute the development of insulin resistance. There is some evidence to suggest this occurs in the context of T1D as well. Exercise training is an effective means to …

Effect Modification Of The Association Between Aerobic Physical Activity And Diabetes-Related Mortality By Race-Ethnicity: A Population-Based Prospective Study Using Nhanes Iii And 1999-2006 Nhanes, William Robert Boyer Ii

Doctoral Dissertations

Purpose: To examine potential effect modification by race-ethnicity of the relationship between physical activity (PA) and diabetes-related mortality risk using a sample of U.S. adults from the Third National Health and Nutrition Examination Survey (NHANES III). Methods: The sample (n=10,717) included adults (≥20 years) who attended the Mobile Examination Center (MEC). An age-standardized PA score (PAS) was calculated from the self-reported frequency and intensity of 12 leisure-time aerobic activities. The PA scores were then grouped into three categories: inactive (PAS = 0), insufficiently active (PAS >0 - Results: There was no interaction between PA and race-ethnicity (p=0.83). Compared to inactive …

The Effect Of Insulin Treatment And Exercise Modality On Skeletal Muscle Fiber Size In Streptozotocin-Induced Type 1 Diabetic Rats, John Z. Nickels

Electronic Thesis and Dissertation Repository

Severe Type 1 Diabetes Mellitus (T1DM) is known to have several negative effects on skeletal muscle mass, a condition known as diabetic myopathy. One of these effects is the atrophy of the glycolytic muscle fibers. However, the role of intensity of insulin treatment and exercise modality in attenuating this loss in fiber cross-sectional area (CSA) specifically has yet to be determined. The purpose of this investigation was to determine the effects of 12 weeks of differing intensity of insulin therapy and exercise modality on the CSA of plantaris muscle fibers, identified by myosin heavy chain (MHC) of STZ-induced T1DM rats. …

Examination Of The Monoamine Oxidase A Gene Promoter On Motivation To Exercise And Levels Of Voluntary Physical Activity, Erin M. Kinney

Senior Theses

Purpose: The purpose of this study was to examine the genetic basis underlying voluntary exercise. Monoamine oxidase A (MAO-A) is an enzyme that acts on monoamine neurotransmitters, such as dopamine, to cause inactivation. There are several polymorphisms in the promoter region of the MAO-A gene, and these variations change transcriptional activity and the amount of MAO-A produced, leading to alterations in available dopamine levels. Interestingly, polymorphisms in MAO-A have been associated recently with physical activity level. This study sought to determine whether there is an association between motivation to exercise, levels of voluntary physical activity, and MAO-A gene polymorphisms.

Methods: …

The Effects Of Caffeine Ingestion On The Hemostatic Response To Simulated Firefighting Activities, Sierra D. Wassell

Masters Theses, 2010-2019

Sudden cardiac events are the leading cause of death among firefighters, and it is acknowledged that most ischemic events are due to an occlusive thrombus formation. In addition, due to the demanding job requirements and shift work, firefighters commonly overuse caffeine. The purpose of this study was to examine the potential effects of caffeine on the hemostatic response to simulated firefighting activity. Twelve healthy male firefighters (age, 31.3 ± 5.4 yrs; weight, 94.2 ± 13.1 kg; BMI, 28.7 ± 2.9 kg·m^-2) participated in this study, wearing full personal protective equipment (PPE) and self-contained breathing apparatus (SCBA). Subjects completed …

The Effects Of Including Physical Activity In Classrooms With Children With Language Disorders, Shelby E. Auer

Honors Theses

As obesity becomes a rising concern in the United States and the importance of high test scores continues to add stress to students, physical activity opportunities are beginning to become less frequent in schools. The Center for Disease Control reports a total of 12.7 million children were classified as obese from 2011 to 2012 (CDC, 2015). While many researchers have also acknowledged this trend, the majority of studies focus on the correlation of physical activity in the classroom with increases in fitness and cognitive functioning levels among average population students, much like the research done by Webster, Russ, Vazou, Goh, …

The Relationship Between Body Image And Exercise Type, Ashley Littrell

Undergraduate Honors Theses

Exercise can have very beneficial effects on health and body satisfaction, but sometimes a negative body image gets in the way of exercising. Modern society holds certain beauty ideals in high regard, and these standards are often unattainable and unrealistic. These outside pressures to look a certain way can have a very negative effect on an individual’s body image, or the way that a person perceives his or her own appearance. There have been many studies done that have attempted to define the relationship between body image with exercise behaviors (Burger and Diony 2002, Hall and Pearson 2013). Some studies …

Nutrition And Exercise Plan For College Students, Rachel Walny

Honors Projects

This is a website designed to help college students lead a healthy and active lifestyle. Many students are unaware of the exercise and nutrition recommendations for adults and have not been in the practice of living on their own and cooking their own meals. It can also be difficult for college students to find time to exercise and eat healthy due to their busy schedules. This source is meant to take some of the planning and questioning out of the process and provide students with a resource that can guide them them in reaching their exercise and nutritional goals.

Assessing A Punching Bag Feedback Performance Device, Neil Deochand

Dissertations

Physical exercise has been integrated into treatment efforts in reversing the number of overweight and obese individuals. Furthermore, exercise extends mortality, enhances general quality of life, and it is a protective health factor for preventing the progression some mental health disorders. Electronic athletic training equipment easily allows monitoring of real-time physical activity, and enables tracking of progress made toward individualized performance goals. There are limitations to only using visual feedback (e.g., visual depictions of heart rate, speed, distance traveled, or calories burned etc.) to track and improve exercise and athletic performance, especially for some sports, such as boxing. This issue …

The Immediate And Extended Effect Of Diet And Exercise On Metabolic Flexibility, Timothy Allerton

LSU Doctoral Dissertations

Metabolic inflexibility is an emerging physiological marker indicative of metabolic dysfunction and associated with type 2 diabetes (T2D) and obesity. Exercise is a potent stimulus to improve metabolic health, however, not much is known about the acute effects of exercise on metabolic flexibility (METFLEX). The purpose of this dissertation was study the time-course of diet and exercise and its effects on METFLEX. Three studies were conducted to investigate molecular and clinical aspects of diet and exercise and how these stimuli may alter the metabolic response to fuel. The first study was conducted on obesity-prone, Osborne-Mendel (OM) and obesity-resistant S5B/Pl (S5B) …

The Effect Of Energy-Matched Exercise Intensity On Brain-Derived Neurotrophic Factor And Motor Learning, Jessica F. Baird

Theses and Dissertations

Brain plasticity is important to motor learning, and is a critical component of motor rehabilitation. Exercise prior to motor training may facilitate plasticity by increasing brain-derived neurotrophic factor (BDNF). However, many studies that have investigated exercise-enhanced plasticity have assessed motor skill performance on tasks involving single finger button presses or small movements of a joystick, results that may not relate to more complex, real-world movements. Additionally, while high-intensity exercise has been shown to benefit motor learning, the effects of low-intensity exercise have yet to be fully investigated. A bout of low-intensity exercise, when completed at an energy expenditure that is …