Life Sciences Commons^™

Bridging The Translational Gap Between Rodent And Human Pain Research, Tayler Diane Sheahan

Arts & Sciences Electronic Theses and Dissertations

The treatment of chronic pain is an immense clinical and societal burden rooted in the ineffectiveness and adverse side effects of existing analgesics. Extensive efforts have been directed towards the development of novel pain therapies with maximal efficacy and minimal unwanted effects; however, putative therapeutic targets identified in preclinical rodent models rarely translate in clinical trials. The poor translational record of basic pain research findings has been attributed, in part, to the use of suboptimal rodent pain models and behavioral endpoints used to assess putative analgesics, as well as differences in the pharmacological profiles of rodents and humans. The work …

Short-Term Effects Of Theracurmin Dose And Exercise Type On Pain, Walking Ability, And Muscle Function In Patients With Knee Osteoarthritis, Yun-A Shin, Min-Hwa Suk, Hee-Seung Jang, Hyejung Choi

Kinesiology Faculty Publications

The purpose of this study was to investigate the short-term of Theracurmin dose and exercise type on pain, walking ability, and muscle function in patients with knee osteoarthritis. Twenty-five patients with knee osteoarthritis randomly selected to Theracurmin intake (T) group and Theracurmin in combined with exercise (T+E) group. T group (n= 13) was taken orally a capsule of 700 mg, 3 times per day, (total 2,100 mg, 35 mg/kg-body weight). T+E group (n= 12) performed aerobic training of 30-min walking and weight training for increasing leg muscular strength. After treatment, the number of steps, muscle mass, range of motion of …

An Examination Of The Influence Of Social Physique Anxiety On Effort And Exercise Participation In College Students, Trellony M. Irwin

Honors Theses

The purpose of this study was to investigate whether an individual’s perception of others influenced exercise participation and effort in women and men participants involved in exercise classes in a campus recreation facility. The study consists of a survey that utilizes the Social Physique Anxiety Scale, the Ratings of Perceived Exertion (RPE) Scale, and demographic information. Results revealed that participants’ social physique anxiety accounted for roughly 30% of the variance in self-reported physical activity. However, when it came to participant effort during the group exercise classes, there was only roughly 2% variance between social physique anxiety and RPE. Further, the …

Pharmaceutical And Natural (Exercise) Mechanisms To Mitigate The Negative Impact Of Ptsd And Chronic Stress On Synaptic Plasticity And Memory, Roxanne M. Miller

Theses and Dissertations

Synapses can be altered due to experiences in a process called synaptic plasticity, which causes memory formations. Synapses can be strengthened through methods known as long-term potentiation (LTP) or weakened through long-term depression (LTD). Stresses can cause changes by altering synapses through either LTP or LTD. Rats were used to study the effects of post-traumatic stress disorder (PTSD)-like symptoms and a prophylactic treatment using pharmaceuticals. The first model used was the single prolonged stress (SPS) with two weeks of chronic light, which was not as effective for causing changes in synaptic plasticity. The second model, seven days of social defeat …

Pharmaceutical And Natural (Exercise) Mechanisms To Mitigate The Negative Impact Of Ptsd And Chronic Stress On Synaptic Plasticity And Memory, Roxanne M. Miller

Theses and Dissertations

Synapses can be altered due to experiences in a process called synaptic plasticity, which causes memory formations. Synapses can be strengthened through methods known as long-term potentiation (LTP) or weakened through long-term depression (LTD). Stresses can cause changes by altering synapses through either LTP or LTD. Rats were used to study the effects of post-traumatic stress disorder (PTSD)-like symptoms and a prophylactic treatment using pharmaceuticals. The first model used was the single prolonged stress (SPS) with two weeks of chronic light, which was not as effective for causing changes in synaptic plasticity. The second model, seven days of social defeat …

The Influence Of Exercise Empowerment On Life Stress, Tonya M. Parker, Colleen Lewis, Christina Beaudoin

Funded Articles

Background: Psychological stress – when an individual perceives that the environment exceeds their ability to meet the demands placed on them - is common in college students and exercise, and specifically instructional physical activity courses, is frequently cited as a one method of stress reduction. Objective: Determine any relationship between exercise empowerment and perceived life stress for those participating in instructional physical activity courses (IPAC). Methods: All undergraduate students (n = 3388) enrolled in IPAC in 15-week IPAC at a large university were surveyed on perceived life stress (PSS), empowerment in exercise (EES), and specific demographic variables. …

Physical Activity And Associated Energy Intake In Undergraduate College Students, Erin Marie Fejes

Theses and Dissertations

Background: College students often develop unhealthy eating habits. Poor eating habits can lead to chronic disease.

Methods: Energy intake and physical activity data from 35 undergraduate students enrolled in a 100-level kinesiology class were recorded and analyzed. Energy intake data was self-reported, while physical activity data was recorded via an activity tracker.

Results: Data points were analyzed twice: each day separately and as averages for each participant. When analyzed as averages, grams of total fat and grams of carbohydrate were the most significantly correlated with minutes of moderate to vigorous+ physical activity (both p<0.01). When analyzed by day, grams of protein, total fat, saturated fat, carbohydrate, sugar, and fiber were all found to be significantly correlated with minutes of moderate to vigorous physical activity to the p≤0.01 level.

Conclusion: An increase in physical activity …

Insulin Resistance And T1d: The Effect Of Exercise On Skeletal Muscle Lipid Metabolism, Michelle Dotzert

Electronic Thesis and Dissertation Repository

Insulin resistance is a characteristic of Type 2 Diabetes (T2D) and metabolic syndrome, and until recently has not been considered in the context of Type 1 Diabetes (T1D). A new classification, Double Diabetes, encompasses the presence of insulin resistance in T1D. Unfortunately, these individuals are at significantly higher risk of cardiovascular complications than those with T1D alone. In T2D, abnormal skeletal muscle lipid metabolism and the accumulation of insulin desensitizing lipid metabolites contribute the development of insulin resistance. There is some evidence to suggest this occurs in the context of T1D as well. Exercise training is an effective means to …

Clinical Outcomes Of Different Tempos Of Music During Exercise In Cardiac Rehabilitation Patients, Jarad S. Miller, Donna J. Terbizan

International Journal of Exercise Science

International Journal of Exercise Science 10(5): 681-689, 2017. This study examined the effects of stimulating and sedative music on ratings of perceived exertion (RPE), heart rate (HR), blood pressure (BP), and feeling status during exercise in cardiac rehabilitation (CR) patients. Twenty-two male and female older adults age 64 ± 8.0 y currently enrolled in phase III CR completed the study. Repeated measures crossover designs guided data collection. The manipulated independent variable was music condition (sedative, stimulating, and non-music control). The dependent variables were RPE, BP, HR, and feeling status with each represented by four repeated measures ANOVAs over time via …

Exercise-Induced Interleukin-6 And Metabolic Responses In Hot, Temperate, And Cold Conditions, Nicholas E. Dinan, Roksana B. Zak, Robert J. Shute, Terry Laursen, Matthew Bubak, D. Taylor La Salle, Matthew W.S. Heesch, Dustin R. Slivka

Journal of Human Performance in Extreme Environments

The purpose of this study was to determine the effects of exercise in hot, cold, and temperate environments on plasma interleukin-6 (IL-6). Eleven recreationally trained males (age = 25 ± 4 years, height = 178 ± 5 cm, weight = 79.4 ± 13.5 kg, body fat = 14.7 ± 3.6%, VO₂ peak = 54.6 ± 11.5 ml kg^-1 min^-1) performed a 1 hr cycling bout in hot (33 °C), cold (7 °C), and temperate (20 °C) environments at 60% of W_max followed by 3 hr of supine recovery in temperate conditions. Expired gases were measured …

Effect Modification Of The Association Between Aerobic Physical Activity And Diabetes-Related Mortality By Race-Ethnicity: A Population-Based Prospective Study Using Nhanes Iii And 1999-2006 Nhanes, William Robert Boyer Ii

Doctoral Dissertations

Purpose: To examine potential effect modification by race-ethnicity of the relationship between physical activity (PA) and diabetes-related mortality risk using a sample of U.S. adults from the Third National Health and Nutrition Examination Survey (NHANES III). Methods: The sample (n=10,717) included adults (≥20 years) who attended the Mobile Examination Center (MEC). An age-standardized PA score (PAS) was calculated from the self-reported frequency and intensity of 12 leisure-time aerobic activities. The PA scores were then grouped into three categories: inactive (PAS = 0), insufficiently active (PAS >0 - Results: There was no interaction between PA and race-ethnicity (p=0.83). Compared to inactive …

A Wellness Study Of 108 Individuals Using Personal, Dense, Dynamic Data Clouds., Nathan D Price, Andrew T Magis, John C Earls, Gustavo Glusman, Roie Levy, Christopher Lausted, Daniel T Mcdonald, Ulrike Kusebauch, Christopher L Moss, Yong Zhou, Shizhen Qin, Robert L Moritz, Kristin Brogaard, Gilbert S Omenn, Jennifer C Lovejoy, L Hood

Articles, Abstracts, and Reports

Personal data for 108 individuals were collected during a 9-month period, including whole genome sequences; clinical tests, metabolomes, proteomes, and microbiomes at three time points; and daily activity tracking. Using all of these data, we generated a correlation network that revealed communities of related analytes associated with physiology and disease. Connectivity within analyte communities enabled the identification of known and candidate biomarkers (e.g., gamma-glutamyltyrosine was densely interconnected with clinical analytes for cardiometabolic disease). We calculated polygenic scores from genome-wide association studies (GWAS) for 127 traits and diseases, and used these to discover molecular correlates of polygenic risk (e.g., genetic risk …

Alternative Interventions For Children Coping With Chronic Conditions: A Critical Review Of The Literature, Nina M. Pelsi, Kim S. Amer

DePaul Discoveries

Reduction of stressors and anxiety levels in adolescents with chronic illnesses is a critical concept in pediatric health care in America today. The many stressors associated with chronic illness include displaying physical and mental differences, social stigma, financial difficulty, and family stress. These stressors may affect the adolescent’s ability to learn and cope in everyday life. The current research was a critical review of the literature examining studies done with adolescents coping with chronic diseases and illnesses. The aim was to analyze the most efficacious non-pharmacological methods for reducing stressors in adolescents with chronic illness. A critical review of the …

The Effect Of Insulin Treatment And Exercise Modality On Skeletal Muscle Fiber Size In Streptozotocin-Induced Type 1 Diabetic Rats, John Z. Nickels

Electronic Thesis and Dissertation Repository

Severe Type 1 Diabetes Mellitus (T1DM) is known to have several negative effects on skeletal muscle mass, a condition known as diabetic myopathy. One of these effects is the atrophy of the glycolytic muscle fibers. However, the role of intensity of insulin treatment and exercise modality in attenuating this loss in fiber cross-sectional area (CSA) specifically has yet to be determined. The purpose of this investigation was to determine the effects of 12 weeks of differing intensity of insulin therapy and exercise modality on the CSA of plantaris muscle fibers, identified by myosin heavy chain (MHC) of STZ-induced T1DM rats. …

Examination Of The Monoamine Oxidase A Gene Promoter On Motivation To Exercise And Levels Of Voluntary Physical Activity, Erin M. Kinney

Senior Theses

Purpose: The purpose of this study was to examine the genetic basis underlying voluntary exercise. Monoamine oxidase A (MAO-A) is an enzyme that acts on monoamine neurotransmitters, such as dopamine, to cause inactivation. There are several polymorphisms in the promoter region of the MAO-A gene, and these variations change transcriptional activity and the amount of MAO-A produced, leading to alterations in available dopamine levels. Interestingly, polymorphisms in MAO-A have been associated recently with physical activity level. This study sought to determine whether there is an association between motivation to exercise, levels of voluntary physical activity, and MAO-A gene polymorphisms.

Methods: …

Role Of Exercise And Stress In Memory And Learning Of The Hippocampus, Paul Baker, Jeff Edwards

Journal of Undergraduate Research

Some of the most devastating diseases today are diseases of the mind. Common side effects of Alzheimer’s disease are dementia and memory loss and more than 44 million people suffer from the disease worldwide [1]. Other mental diseases such as Parkinson’s also have a dramatic impact on the memory and learning pathways. Understanding the mechanism involved with memory and learning will bring science that much closer to finding a permanent cure to these devastating diseases.

King-Devick Performance Following Moderate And High Exercise Intensity Bouts., Billymo Rist, Adrian Cohen, Alan J. Pearce

International Journal of Exercise Science

International Journal of Exercise Science 10(4): 619-628, 2017. The King-Devick (K-D) test is a concise, noninvasive assessment of oculomotor and cognitive function that has been shown to detect sub-optimal brain performance following sports head trauma. Used in a number of sports as a sideline concussion assessment tool, the K-D test can be administered by non-medical personnel. However, the issue regarding the effect of exercise on K-D performance has not been fully explored. Using a randomized crossover design, this study aimed to compare the effect of two intensities of exercise on K-D performance. Twenty males (21.2 ± 1.9 years) completed the …

Optimal Nutrition For Endurance Exercise: A Systematic Review, Sarah E. Andrus Ms, Bruce W. Andrus Md Ms

Dartmouth Scholarship

Introduction

As fatigue in endurance events correlates with depletion of muscle glycogen, the traditional approach to nutritional support has been carbohydrate loading. However, there has been recent interest in improving athletic endurance performance by novel diets in the days to weeks prior to endurance events, the pre-event meal, and during exercise.

Methods

We searched PubMed and SCOPUS for randomized trials published from 1992-2017 with a primary endpoint of endurance performance. We identified 407 citations which were examined against our inclusion criteria of randomization or crossover allocation to diet and for which a primary outcome was endurance performance.

Results

Twenty full …

The Effects Of Caffeine Ingestion On The Hemostatic Response To Simulated Firefighting Activities, Sierra D. Wassell

Masters Theses, 2010-2019

Sudden cardiac events are the leading cause of death among firefighters, and it is acknowledged that most ischemic events are due to an occlusive thrombus formation. In addition, due to the demanding job requirements and shift work, firefighters commonly overuse caffeine. The purpose of this study was to examine the potential effects of caffeine on the hemostatic response to simulated firefighting activity. Twelve healthy male firefighters (age, 31.3 ± 5.4 yrs; weight, 94.2 ± 13.1 kg; BMI, 28.7 ± 2.9 kg·m^-2) participated in this study, wearing full personal protective equipment (PPE) and self-contained breathing apparatus (SCBA). Subjects completed …

The Effects Of Including Physical Activity In Classrooms With Children With Language Disorders, Shelby E. Auer

Honors Theses

As obesity becomes a rising concern in the United States and the importance of high test scores continues to add stress to students, physical activity opportunities are beginning to become less frequent in schools. The Center for Disease Control reports a total of 12.7 million children were classified as obese from 2011 to 2012 (CDC, 2015). While many researchers have also acknowledged this trend, the majority of studies focus on the correlation of physical activity in the classroom with increases in fitness and cognitive functioning levels among average population students, much like the research done by Webster, Russ, Vazou, Goh, …

Triathlon Training For Women Breast Cancer Survivors: Feasibility And Initial Efficacy, Alex V. Ng, Alyson Cybulski, Ashley A. Engel, Paula E. Papanek, Megn A. Sheffer, Leslie J. Waltke, Judy A. Tjoe

Exercise Science Faculty Research and Publications

Exercise can improve quality of life (QOL) in breast cancer survivors. In contrast to many group or home-based exercise programs, little is known about the effectiveness of goal-oriented recreational activities.

Purpose

The purpose of this study was to evaluate a clinically overseen team triathlon training program on improving physiological and psychosocial health-related measures in female breast cancer survivors.

Methods

Twenty-three participants (age = 48 (8), BMI = 25 (1), mean (SE)) were recruited from a 14-week sprint triathlon (800-m swim, 20-km bike, 5-km run) team training program for women breast cancer survivors (4 (3) years post-surgery, chemo-, or radiation-therapy). Training …

The Relationship Between Body Image And Exercise Type, Ashley Littrell

Undergraduate Honors Theses

Exercise can have very beneficial effects on health and body satisfaction, but sometimes a negative body image gets in the way of exercising. Modern society holds certain beauty ideals in high regard, and these standards are often unattainable and unrealistic. These outside pressures to look a certain way can have a very negative effect on an individual’s body image, or the way that a person perceives his or her own appearance. There have been many studies done that have attempted to define the relationship between body image with exercise behaviors (Burger and Diony 2002, Hall and Pearson 2013). Some studies …

Nutrition And Exercise Plan For College Students, Rachel Walny

Honors Projects

This is a website designed to help college students lead a healthy and active lifestyle. Many students are unaware of the exercise and nutrition recommendations for adults and have not been in the practice of living on their own and cooking their own meals. It can also be difficult for college students to find time to exercise and eat healthy due to their busy schedules. This source is meant to take some of the planning and questioning out of the process and provide students with a resource that can guide them them in reaching their exercise and nutritional goals.

Resistance Training Contribute To The Aerobic Components Of An Exercise Session In Adults But Not As Much In Older Adults, Neha Bharti, Travis Hrubeniuk, Andrea Mayo, Martin Senechal, Danielle R. Bouchard

International Journal of Exercise Science

International Journal of Exercise Science 10(3): 406-416, 2017. Previous research has indicated that active adults are able to achieve moderate intensity as measured via heart rate during a typical resistance training (RT) session. The main objective was to identify if overweight adults and older adults can reach aerobic moderate intensity at a rate comparable to adults displaying a recommended body mass index. Twenty participants in each group were asked to visit a fitness facility twice if they self-reported doing RT for a minimum two days per week. At the first session baseline characteristics and maximal lifting capacity for each RT …

Assessing A Punching Bag Feedback Performance Device, Neil Deochand

Dissertations

Physical exercise has been integrated into treatment efforts in reversing the number of overweight and obese individuals. Furthermore, exercise extends mortality, enhances general quality of life, and it is a protective health factor for preventing the progression some mental health disorders. Electronic athletic training equipment easily allows monitoring of real-time physical activity, and enables tracking of progress made toward individualized performance goals. There are limitations to only using visual feedback (e.g., visual depictions of heart rate, speed, distance traveled, or calories burned etc.) to track and improve exercise and athletic performance, especially for some sports, such as boxing. This issue …

Efficacy Of A Mobile Application For Improving Gait Performance In Community-Dwelling Older Adults, Dustin Glenn Falls

Masters Theses & Specialist Projects

The United States is a rapidly aging nation. Older adults have higher rates of falls than any other age group. One in four older adults fall each year. Many of these falls are associated with sedentary lifestyles and decreased muscular strength effecting balance and gait performance. Physical activity (exercise) can reduce the risk of falls among older adults, yet adherence remains low. Exergames can increase adherence to interventions that promote health and physical activity. Social engagement can increase self-efficacy and motivation to exercise. By design, the Bingocize® health promotion mobile application (app) increases social engagement, while providing a multi-factorial fall …

A 15-Week Vitamin D Supplementation And Indoor Cycling Intervention Reduces Exercising Heart Rate, With No Effect On Glycaemic Control In Healthy Adults: A Pilot Investigation., Ffion Curtis, Rhys Thatcher, Sam Rice, Glen Davison

International Journal of Exercise Science

International Journal of Exercise Science 10(2): 274-283, 2017 Significant positive correlations are often observed between vitamin D concentrations and physical activity levels. Whilst this may be due to individuals who are physically active spending time outdoors (i.e. increased opportunity for vitamin D synthesis), there is growing evidence to suggest a more complex relationship between vitamin D status, physical fitness and health outcomes. To explore this further thirty-nine healthy adults were randomly allocated to 15 weeks of exercise training (Ex), no training (NoEx), 2000 IU/day vitamin D (VitD) and/or placebo (Pla) supplementation (giving four possible allocations: NoEx+VitD; NoEx+Pla; Ex+VitD; Ex+Pla). Vitamin …

Parental Influences And The Relationship To Their Children’S Physical Activity Levels, Nathan Chiarlitti, Angela Kolen

International Journal of Exercise Science

International Journal of Exercise Science 10(2): 205-212, 2017 Engaging in a physically active lifestyle relates positively to current health and reduces chances of chronic diseases in the future. Given escalating health care costs, it is paramount to reduce illnesses associated with a lack of physical activity and thus critical to identify factors that influence physical activity - especially in children, with the opportunity for a lifetime impact. One of these influencing factors may be parents/guardians. The intent of this study was to examine the relationship between children’s physical activity levels and parental factors including parental physical activity, support/encouragement, restrictiveness, and …

Implementing Exercise In Cancer Care: Study Protocol To Evaluate A Community-Based Exercise Program For People With Cancer, Prue Cormie, Stephanie Lamb, Robert Newton, Lani Valentine, Sandy Mckiernan, Nigel Spry, David Joseph, Dennis Taaffe, Christopher M. Doran, Daniel A. Galvão

Research outputs 2014 to 2021

Background

Clinical research has established the efficacy of exercise in reducing treatment-related side-effects and increasing wellbeing in people with cancer. Major oncology organisations have identified the importance of incorporating exercise in comprehensive cancer care but information regarding effective approaches to translating evidence into practice is lacking. This paper describes the implementation of a community-based exercise program for people with cancer and the protocol for program evaluation.

Methods/Design

The Life Now Exercise program is a community-based exercise intervention designed to mitigate and rehabilitate the adverse effects of cancer and its treatment and improve physical and psychosocial wellbeing in people with cancer. …

Metastable Pain-Attention Dynamics During Incremental Exhaustive Exercise, Agnė Slapšinskaitė, Robert Hristovski, Selen Razon, Natàlia Balagué, Gershon Tenenbaum

Selen Razon

No abstract provided.