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Spatial Control Of Cdc42 Activation Regulates Cell Width And Growth Zone Formation, Felice D. Kelly

Student Theses and Dissertations

The fission yeast Schizosaccharomyces pombe is a rod--‐shaped cell that grows by linear extension at the cell tips, with a nearly constant width throughout the cell cycle. This simple geometry makes it a good system to study the control of cellular dimensions. Here I used the width of the cell as a model for the control of growth zone size. To identify genes that influence cell size I carried out a near--‐genome--‐widescreen for mutants wider than wild--‐type cells. I found eleven deletion mutants that were wider; seven of the deleted genes are implicated in the control of the small GTPase …