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Full-Text Articles in Life Sciences
Spatial Control Of Cdc42 Activation Regulates Cell Width And Growth Zone Formation, Felice D. Kelly
Spatial Control Of Cdc42 Activation Regulates Cell Width And Growth Zone Formation, Felice D. Kelly
Student Theses and Dissertations
The fission yeast Schizosaccharomyces pombe is a rod--â€shaped cell that grows by linear extension at the cell tips, with a nearly constant width throughout the cell cycle. This simple geometry makes it a good system to study the control of cellular dimensions. Here I used the width of the cell as a model for the control of growth zone size. To identify genes that influence cell size I carried out a near--â€genome--â€widescreen for mutants wider than wild--â€type cells. I found eleven deletion mutants that were wider; seven of the deleted genes are implicated in the control of the small GTPase …
Controls Over S-Phase And Over Nuclear Synchrony, Lee Maxine Kiang
Controls Over S-Phase And Over Nuclear Synchrony, Lee Maxine Kiang
Student Theses and Dissertations
Nearly forty years ago, cell fusion experiments revealed two tenets of our understanding of the cell cycle today. One, controls maintain ordered progression of the cell cycle. Two, diffusible factors in the cytoplasm promote cell cycle transitions. The studies presented here stem from those principles. In fission yeast, Schizosaccharomyces pombe, we have investigated the controls over S-phase within the cell cycle and over S-phase and mitosis among multiple nuclei within a common cytoplasm. To achieve faithful replication of the genome in each cell cycle, re-initiation of S-phase is prevented in G2 and origins are restricted from re-firing within S-phase. Failure …