Life Sciences Commons^™

Football Helmet Fitment And Its Effect On Helmet Performance, Ron Jadischke

Wayne State University Theses

A method and system to objectively quantify helmet fitment was designed and developed. It measures the pressure between the energy-absorbing material in the helmet and the athlete's head. This system is also capable of measuring surface pressure during impact events. A volunteer-based field study was conducted to quantify how helmets were fitting athletes in a real-life setting. The helmets fit athletes in varying degrees of tightness and evenness. Most athletes (59%) had the highest pressures in the frontal area and 29% had the highest pressure in the occipital area. A large-sized helmet on the Hybrid III headform represented how most …

Contact Pressure Distribution Of Osteochondral Defects Of The Knee: Effects Of Non-Vertical Walls, Scott Ensminger

Wayne State University Theses

Purpose: To examine the relationship between well-shouldered osteochondral defects and

defects of different geometries by studying their effects on rim stress concentration and

load redistribution in the human knee.

Methods: Ten fresh-frozen cadaveric knees were mounted at 30° of flexion in a materials

testing machine. Digital electronic pressure sensors were placed in the medial and lateral

compartments of the knee. Dynamic pressure readings were recorded throughout the

loading and holding phases as each knee was loaded to 700N and held for 5 seconds.

Artificial defects were created in each knee to simulate well-shouldered defects and

beveled-defects. Loading was repeated for …

Protein Based Biomimetic Approachs To Surface Hemocompatibility And Biocompatibility Enhancement, Matthew Thomas Dickerson

Theses and Dissertations--Chemical and Materials Engineering

T. pallidum can survive a primary immune response and continue growing in the host for an extended period of time. T. pallidum is thought to bind serum fibronectin (FN) through Tp0483 on the surface to obscure antigens. A Tp0483 fragment (rTp0483) was adsorbed onto functionalized self-assembled monolayers (SAMs) with FN. FN capture by adsorbed rTp0483 depended greatly on surface chemistry with COO- groups being best for FN binding. Hemocompatibility was determined by analysis of plasma protein adsorption, intrinsic pathway activation, and platelet activation. rTp0483+FN bound an equal or lesser amount of fibrinogen (Fg), human serum albumin (HSA), and factor XII …

Sustainable Disposal Of Brine, Bijoy Krishna Halder

Open Access Theses & Dissertations

To meet growing water demand, more water is being harvested from nontraditional sources like brackish water from deep underground aquifers. Since these sources contain salts, drinkable water is produced by separating salt and other minerals (TDS, Total Dissolved Solids) from water through a process commonly known as desalination. A typical desalination plant produces 50-60% potable water from brackish water and the remaining water (brine) is disposed in evaporation ponds or by injecting it below the ground surface. To maximize the limited water supply, inland desalination plants have developed technologies to reduce brine production commonly known as zero liquid discharge (ZLD) …

Dolphin Sound Production And Distribution On The West Florida Shelf, Peter Simard

USF Tampa Graduate Theses and Dissertations

This dissertation is an investigation of dolphin sound production and distribution off west central Florida. Although a wealth of information exists on the production of common sounds (whistles, echolocation) made by captive, trained dolphins, far less is known about free-ranging dolphin sound production and of unusual sounds. In addition, while inshore dolphin populations or communities are the subjects of research projects in many locations, dolphins in offshore waters are less commonly studied. The objectives of this dissertation were to contribute information on free-ranging dolphin sounds and continental shelf dolphin distribution.

While echolocation has been rigorously studied in captive, trained dolphins, …

Structural Basis Of Substrate Recognition In Thimet Oligopeptidase And Development Of Nanoparticles For Therapeutic Enzyme Delivery, Jonathan Mark Wagner

Theses and Dissertations--Molecular and Cellular Biochemistry

Neuropeptidases are responsible for degradation of signaling peptides in the central nervous system and periphery. Some neuropeptidases have also been shown to play a role as part of the cell’s hydrolytic machinery responsible for breaking down proteins and peptides into amino acids, and these enzymes therefore influence small peptide availability for antigen presentation. A better understanding of how neuropeptidases recognize their substrates could lead to therapeutics that modulate the activity of these important enzymes. Alternatively, re-engineering these enzymes to selectively hydrolyze undesirable peptides could make them attractive as therapeutics themselves. A key question in understanding the activity of these enzymes …

Economic Modeling & Optimization Of A Region Specific Multi-Feedstock Biorefinery Supply Chain, William H. Faulkner

Theses and Dissertations--Manufacturing Systems Engineering

The objective of this thesis is to include strategic and tactical level decisions into the biorefinery supply chain design for a specific region while comparing multiple conversion technologies and biomass feedstocks. The allocation of biomass feedstocks, products, and the respective supply chain configuration locations are determined while ensuring the regions monthly biomass availability and product market demand constraints are met. This research considers all actions required to bring the bio-based products to market from harvesting, storing, and processing the biomass to market distribution. Two different conversion technologies are chosen for comparison: one advanced conversion technology and one conventional technology. Potential …

Virus Capsids As Nanoscale Delivery Vessels Of Photoactive Compounds For Site-Specific Photodynamic Therapy, Brian Alexander Cohen

Legacy Theses & Dissertations (2009 - 2024)

The research presented in this work details the use of a viral capsid as an addressable delivery vessel of photoactive compounds for use in photodynamic therapy. Photodynamic therapy is a treatment that involves the interaction of light with a photosensitizing molecule to create singlet oxygen, a reactive oxygen species. Overproduction of singlet oxygen in cells can cause oxidative damage leading to cytotoxicity and eventually cell death. Challenges with the current generation of FDA-approved photosensitizers for photodynamic therapy primarily stem from their lack of tissue specificity. This work describes the packaging of photoactive cationic porphyrins inside the MS2 bacteriophage capsid, followed …

Bifunctional Bisphosphonates For Delivering Biomolecules To Bone, Jivan N. Yewle

Theses and Dissertations--Chemistry

Active targeting with controlled delivery of therapeutic agents to bone is an ideal approach for treatment of several bone diseases. Since bisphosphonates (BPs) are known to have high affinity to bone mineral and are being widely used in treatment of osteoporosis, they are well-suited for drug targeting to bone. For this purpose, bifunctional hydrazine-bisphosphonates (HBPs) with spacers of various lengths and lipophilicity were synthesized and studied. Crystal growth inhibition assays demonstrated that the HBPs with shorter spacers bound more strongly to bone mineral, hydroxyapatite (HA), than did alendronate. HBPs were also demonstrated to be non-toxic to MC3T3-E1 pre-osteoblasts. The targeted …

Investigations Of Oxidative Stress Effects And Their Mechanisms In Rat Brain After Systemic Administration Of Ceria Engineered Nanomaterials, Sarita S. Hardas

Theses and Dissertations--Chemistry

Advancing applications of engineered nanomaterials (ENM) in various fields create the opportunity for intended (e.g. drug and gene delivery) or unintended (e.g. occupational and environmental) exposure to ENM. However, the knowledge of ENM-toxicity is lagging behind their application development. Understanding the ENM hazard can help us to avoid potential human health problems associated with ENM applications as well as to increase their public acceptance. Ceria (cerium [Ce] oxide) ENM have many current and potential commercial applications. Beyond the traditional use of ceria as an abrasive, the scope of ceria ENM applications now extends into fuel cell manufacturing, diesel fuel additives …

Development Of A Noncontact Sensor For Monitoring Milk Coagulation And Cutting Time Prediction In Cheese Making, Molly D. Craft-Jenkins

Theses and Dissertations--Biosystems and Agricultural Engineering

Cheese products are manufactured more consistently and with better quality if the curd cutting time can be consistently selected. An optical sensor that accurately predicts cutting time has been developed for large cheese vats, but the initial cost of these sensors makes them uneconomical for small artisan cheese manufacturers. The small artisan cheese vats require an inexpensive sensor technology that can be implemented simply. The initial cost of purchasing a sensor and installing these sensors plus the need for a computational program for implementing the algorithm make this technology excessively expensive for these smaller cheese manufacturers. The objective of this …

Micropatterned Electrospun Nanofibrous Substrates As Scaffolds For Engineered Salivary Glands, David Alexander Soscia

Legacy Theses & Dissertations (2009 - 2024)

The salivary gland is a complex organ exhibiting a branching, 3-dimensional structure made up of acinar (saliva-producing), and ductal (saliva transporting and modifying) epithelial cells. The high surface area of the gland allows it to efficiently provide the mouth with saliva, maintaining oral cleanliness and comfort. Salivary gland hypofunction, a significant clinical problem often caused by the autoimmune disease Sjögren's syndrome or head and neck radiation for cancer patients, affects millions of Americans and is characterized by a loss of function of salivary gland acinar cells. Chronic xerostomia, or dry mouth, arises as a result of salivary gland hypofunction and …