Life Sciences Commons^™

Dysregulated Interferon Response Underlying Severe Covid-19, Leann Lopez, Peter C. Sang, Yun Tian, Yongming Sang

Agricultural and Environmental Sciences Faculty Research

Innate immune interferons (IFNs), including type I and III IFNs, constitute critical antiviral mechanisms. Recent studies reveal that IFN dysregulation is key to determine COVID-19 pathogenesis. Effective IFN stimulation or prophylactic administration of IFNs at the early stage prior to severe COVID-19 may elicit an autonomous antiviral state, restrict the virus infection, and prevent COVID-19 progression. Inborn genetic flaws and autoreactive antibodies that block IFN response have been significantly associated with about 14% of patients with life-threatening COVID-19 pneumonia. In most severe COVID-19 patients without genetic errors in IFN-relevant gene loci, IFN dysregulation is progressively worsened and associated with the …

Knowledge, Attitudes, And Practices Against The Growing Threat Of Covid-19 Among Medical Students Of Pakistan, Khola Noreen, Zil-E Rubab, Muhammad Umar, Rehana Rehman, Mukhtiar Baig, Fizzah Baig

Department of Biological & Biomedical Sciences

Background: On account of the COVID-19 pandemic, many changes have been implicated in university medical students. We are cognizant that pandemic can be controlled with dedicated contributions from all involved in the healthcare profession. Therefore, it is important to know the pandemic and application of knowledge by the medical students to formulate a further line of management in Pakistan.
Objective: We aimed toinvestigate the knowledge, attitudes, and practices (KAP) regarding COVID-19 and its impact on medical students of Pakistan.
Methods: A cross-sectional survey was conducted in June 2020 by a validated self-administered questionnaire. The survey instrument was tailored from a …

Sex Differences In Self-Report Anxiety And Sleep Quality During Covid-19 Stay-At-Home Orders, Jeremy Bigalke, Ian Greenlund, Jason R. Carter

Michigan Tech Publications

Background: COVID-19 and home isolation has impacted quality of life, but the perceived impact on anxiety and sleep remains equivocal. The purpose of this study was to assess the impact of COVID-19 and stay-at-home orders on self-report anxiety and sleep quality, with a focus on sex differences. We hypothesized that the COVID-19 pandemic would be associated with increased anxiety and decreased sleep quality, with stronger associations in women. Methods: One hundred three participants (61 female, 38 ± 1 years) reported perceived changes in anxiety and sleep quality due to stay-at-home orders during the COVID-19 pandemic and were administered the Spielberger …

Applications Of Non-Invasive Neuromodulation For The Management Of Disorders Related To Covid-19, Abrahão Fontes Baptista, Adriana Baltar, Alexandre Hideki Okano, Alexandre Moreira, Ana Carolina Pinheiro Campos, Ana Mércia Fernandes, André Russowsky Brunoni, Bashar W. Badran, Clarice Tanaka, Daniel Ciampi De Andrade, Daniel Gomes Da Silva Machado, Edgard Morya, Eduardo Trujillo, Jaiti K. Swami, Joan A. Camprodon, Katia Monte-Silva, Katia Nunes Sá, Isadora Nunes, Juliana Barbosa Goulardins, Marom Bikson, Pedro Sudbrack-Oliveira, Priscila De Carvalho, Rafael Jardim Duarte-Moreira, Rosana Lima Pagano, Samuel Katsuyuki Shinjo, Yossi Zana

Publications and Research

Background: Novel coronavirus disease (COVID-19) morbidity is not restricted to the respiratory system, but also affects the nervous system. Non-invasive neuromodulation may be useful in the treatment of the disorders associated with COVID-19.

Objective: To describe the rationale and empirical basis of the use of non-invasive neuromodulation in the management of patients with COVID-10 and related disorders.

Methods: We summarize COVID-19 pathophysiology with emphasis of direct neuroinvasiveness, neuroimmune response and inflammation, autonomic balance and neurological, musculoskeletal and neuropsychiatric sequela. This supports the development of a framework for advancing applications of non-invasive neuromodulation in the management COVID-19 and related disorders.

Results: …

Immunogenetic Association Underlying Severe Covid-19, Kendall Mccoy, Autumn Peterson, Yun Tian, Yongming Sang

Agricultural and Environmental Sciences Faculty Research

SARS-CoV2 has caused the current pandemic of new coronavirus disease 2019 (COVID-19) worldwide. Clinical outcomes of COVID-19 illness range broadly from asymptotic and mild to a life-threatening situation. This casts uncertainties for defining host determinants underlying the disease severity. Recent genetic analyses based on extensive clinical sample cohorts using genome-wide association studies (GWAS) and high throughput sequencing curation revealed genetic errors and gene loci associated with about 20% of life-threatening COVID-19 cases. Significantly, most of these critical genetic loci are enriched in two immune signaling pathways, i.e., interferon-mediated antiviral signaling and chemokine-mediated/inflammatory signaling. In line with these genetic profiling studies, …

Update On The Use Of Transcranial Electrical Brain Stimulation To Manage Acute And Chronic Covid-19 Symptoms, Giuseppina Pilloni, Marom Bikson, Bashar W. Badran, Mark S. George, Steven A. Kautz, Alexandre Hideki Okano, Abrahão Fontes Baptista, Leigh E. Charvet

Publications and Research

The coronavirus disease 19 (COVID-19) pandemic has resulted in the urgent need to develop and deploy treatment approaches that can minimize mortality and morbidity. As infection, resulting illness, and the often prolonged recovery period continue to be characterized, therapeutic roles for transcranial electrical stimulation (tES) have emerged as promising non-pharmacological interventions. tES techniques have established therapeutic potential for managing a range of conditions relevant to COVID-19 illness and recovery, and may further be relevant for the general management of increased mental health problems during this time. Furthermore, these tES techniques can be inexpensive, portable, and allow for trained self-administration. Here, …

Covid-19_Umaine News_Campus As Living Laboratory, University Of Maine Division Of Marketing And Communications

Division of Marketing & Communications

Screenshot of UMaine News press release regarding EES 217 field course led by Kate Ruskin, a University of Maine lecturer and undergraduate coordinator in the Ecology and Environmental Sciences Program being held on campus to assess the tick risk on UMaine’s campus, in collaboration with UMaine professor Allison Gardner’s lab, the EES 217 students examined the vegetation, wildlife and abiotic associations of ticks on campus.

Covid-19_Umaine News_Animal And Veterinary Sciences Seniors: Capstone Stories, University Of Maine Division Of Marketing And Communications

Division of Marketing & Communications

Screenshot of UMaine News press release regarding University of Maine animal and veterinary sciences capstone course AVS 401, students having the opportunity to combine their knowledge and skills with ongoing research of UMaine faculty.

Fundamental Shifts In Research, Ethics And Peer Review In The Era Of The Covid-19 Pandemic, Edward Barroga, Janet B. Matanguihan

Biology Educator Scholarship

The era of the coronavirus disease 2019 (COVID-19) pandemic has led to fundamental shifts in research, ethics, and peer review including reframing of the research design, adapting methodologies to the study type, transitioning of research mechanics, changing research methodologies, overcoming data collection and standardization constraints, upholding research standards and ethics, maintaining informativeness and social value, and providing guarded peer review flexibility. Indeed, the COVID-19 crisis, despite disrupting research worldwide to an unprecedented degree, has also become a catalyst to develop strategies of adaptation to this disruption. As the COVID-19 pandemic continuous to evolve, new, cost-effective, and highly flexible research models …

Eating Habits And Lifestyle During Covid-19 Lockdown In The United Arab Emirates: A Cross-Sectional Study, Leila Cheikh Ismail, Tareq M. Osaili, Maysm N. Mohamad, Amina Al Marzouqi, Amjad H. Jarrar, Dima O.Abu Jamous, Emmanuella Magriplis, Habiba I. Ali, Haleama Al Sabbah, Hayder Hasan, Latifa M.R. Almarzooqi, Lily Stojanovska, Mona Hashim, Reyad R.Shaker Obaid, Sheima T. Saleh, Ayesha S.Al Dhaheri

All Works

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The coronavirus disease is still spreading in the United Arab Emirates (UAE) with subsequent lockdowns and social distancing measures being enforced by the government. The purpose of this study was to assess the effect of the lockdown on eating habits and lifestyle behaviors among residents of the UAE. A cross-sectional study among adults in the UAE was conducted using an online questionnaire between April and May 2020. A total of 1012 subjects participated in the study. During the pandemic, 31% reported weight gain and 72.2% had less than eight cups of …

Outbreak Of Coronavirus Disease 2019 (Covid 19) In Pakistan: Psychological Impact And Coping Strategies Of Health Care Professionals, Khola Noreen, Muhammad Umar, Syed Arshad Sabir, Rehana Rehman

Department of Biological & Biomedical Sciences

Objective: This study was conducted to explore factors that can impact psychological health and coping strategies to help health care professionals (HCPs) to perform their duties.
Methods: A cross sectional survey was conducted using structured questionnaire electronically shared with the participants after ethical approval. Descriptive statistics were calculated for socio demographic variables. Chi squared χ² test was used to compare the responses between different groups of HCPs.
Results: Survey was completed by 250 participants. They performed their duties diligently during outbreak but were concerned about their safety, had fear of infecting themselves and their family members. Lack of evidence-based …

Intention To Vaccinate Against The Novel 2019 Coronavirus Disease: The Role Of Health Locus Of Control And Religiosity, Ayokunle Olagoke, Olakanmi Olagoke, Ashley M. Hughes

Health and Kinesiology Faculty Publications

The urgency to develop a vaccine against the 2019 coronavirus (COVID-19) has waxed stronger in speed, scale, and scope. However, wisdom dictates that we take a vantage position and start to examine the demographic predictors of COVID-19 vaccine hesitancy. The objective of this study was to examine the role of health locus of control (HLOC) in the relationship between religiosity and COVID-19 vaccination intention. In a cross-sectional survey (N = 501), we found a significantly negative association between religiosity and COVID-19 vaccination intention. This relationship was partially mediated by external HLOC. Collaborative efforts with religious institutions may influence COVID-19 vaccine …

Covid-19_Umaine News_Carter Recent Guest In ‘Maine Calling’ Segment About Mainers Helping Each Other During Pandemic, University Of Maine Division Of Marketing And Communications

Division of Marketing & Communications

Screenshot of UMaine in the News regarding Maine Public featuring Hannah Carter, Dean of University of Maine Cooperative Extension, on a segment of 'Maine Calling' about how Mainers have helped one another during the COVID-19 pandemic.

Covid-19_Umaine News_Marine Science Course Connects Distant Students Of Sustainability Science, University Of Maine Division Of Marketing And Communications

Division of Marketing & Communications

Screenshot of UMaine News release regarding Marine science course connecting distant students of sustainability science.

Covid-19_Umaine News_Umaine Professors Contribute To Report Advising How Governments Can Tackle Biodiversity Loss Through Covid-19 Recovery, University Of Maine Division Of Marketing And Communications

Division of Marketing & Communications

Screenshot of UMaine News release regarding two University of Maine professors contributing to a report that explores how governments can help mitigate ecosystem and species loss through their COVID-19 stimulus and recovery plans.

Return To Campus_Learning Environment, University Of Maine

University of Maine Communications

Screenshot of University of Maine Fall 2020 webpage regarding SFR220 - Environment and Society, professor Jessica Leahy cancelling a week of lectures focused on public lands and asked students to spend an hour hiking, walking and otherwise experiencing conservation areas near them. Also, for SFR478 - Tools for Forest Management Leahy modified the course to take advantage of forests managed by the University of Maine and Orono Land Trust that were within walking distance of campus.

Mitchell Center_Safety Nets And Boostraps Talk Webpage, University Of Maine Senator George J. Mitchell Center For Sustainability Solutions

Mitchell Center for Sustainability Solutions

Screenshot of webpage regarding a talk from the University of Maine Senator George J. Mitchell Center for Sustainability Solutions titled "Safety nets and bootstraps: Mainers and food security in the time of COVID-19".

Ensuring A Post-Covid Economic Agenda Tackles Global Biodiversity Loss, Pamela Mcelwee, Esther Turnout, Mireille Chiroleu-Assouline, Jennifer Clapp, Cindy Isenhour, Tim Jackson, Eszter Kelemen, Daniel C. Miller, Graciela Rusch, Joachim H. Spangenberg, Anthony Waldron, Rupert J. Baumgartner, Brent Bleys, Michael W. Howard, Eric Mungatana, Hien Ngo, Irene Ring, Rui Santos

Teaching, Learning & Research Documents

Report that explores how governments can help mitigate ecosystem and species loss through their COVID-19 stimulus and recovery plans.

Lifelines Fall 2020, Southern Adventist University

Lifelines - Biology Department Newsletter

The Fall 2020 issue of Lifelines contains articles on Insights from the Professor, Alumni Highlight, and Department Happenings.

Endothelial Cell Contributions To Covid-19, Alexandra E. Oxford, Fabio Halla, Evan B. Robertson, Brad E. Morrison

Biology Faculty Publications and Presentations

Understanding of the clinical, histological and molecular features of the novel coronavirus 2019 (Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)) has remained elusive. Coronavirus disease 2019 (COVID-19) caused by this virus has unusual clinical presentation with regard to other related coronaviruses. Recent reports suggest that SARS-CoV-2, unlike other related viruses, infects and replicates within endothelial cells, which may explain a significant portion of the observed clinical pathology. Likewise, mounting evidence associates vascular and endothelial cell dysfunction with increased mortality. This review focuses on understanding how endothelial cell pathology is caused by SARS-CoV-2 at the molecular and cellular levels and how …

Covid-19_Umaine News_Plant Studies During The Pandemic Umaine Instructor Incorporates Flexibility, Support Network O Preserve Outdoor Learning, University Of Maine Division Of Marketing And Communications

Division of Marketing & Communications

Screenshot of Maine News release regarding Jose "Dudu" Meireles, UMaine assistant professor of plant systematics incorporating flexibility, support network to preserve outdoor learning.mark

A Review Of The Preclinical And Clinical Efficacy Of Remdesivir, Hydroxychloroquine, And Lopinavir-Ritonavir Treatments Against Covid-19, Dawid Maciorowski, Samir Z. El Idrissi, Yash Gupta, Brian J. Medernach, Michael B. Burns, Daniel P. Becker Ph.D., Ravi Durvasula, Prakasha Kempaiah

Chemistry: Faculty Publications and Other Works

In December of 2019, an outbreak of a novel coronavirus flared in Wuhan, the capital city of the Hubei Province, China. The pathogen has been identified as a novel enveloped RNA beta-coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus SARS-CoV-2 is associated with a disease characterized by severe atypical pneumonia known as coronavirus 2019 (COVID-19). Typical symptoms of this disease include cough, fever, malaise, shortness of breath, gastrointestinal symptoms, anosmia, and, in severe cases, pneumonia.¹ The high-risk group of COVID-19 patients includes people over the age of 60 years as well as people with existing cardiovascular …

Covid-19_Umaine News_Press Herald Talks With Savoie About Increased Interest In Canning, University Of Maine Division Of Marketing And Communications

Division of Marketing & Communications

Screenshot of UMaine in the News regarding the Portland Press Herald speaking with Kathleen Savoie, University of Maine Cooperative Extension educator, about attendance at UMaine Extension webinars focused on food preservation and the burgeoning demand for canning support and supplies.

Covid-19_Umaine News_Bdn Interviews Coffin About Contact Tracing For Livestock, University Of Maine Division Of Marketing And Communications

Division of Marketing & Communications

Screenshot of UMaine in the News regarding Donna Coffin, a University of Maine Cooperative Extension professor, being interviewed for a Bangor Daily News story about contact tracing for livestock

Covid-19_Umaine News_Mccarty Highlights Supply Shortages In Maine Public Segment, University Of Maine Division Of Marketing And Communications

Division of Marketing & Communications

Screenshot of UMaine in the News regarding Kate McCarty, a University of Maine Cooperative Extension food systems professional talking with Maine Public about the increase in home canning during the pandemic, and the resulting shortage of food preservation supplies.

Commentary: Physiological And Psychological Impact Of Face Mask Usage During The Covid-19 Pandemic, Jennifer Scheid, Shannon Lupien, Gregory Scott Ford, Sarah West

Articles & Book Chapters

In this commentary, we discuss the physiological effects of wearing masks for prolonged periods of time, including special considerations, such as mask wearing among those who engage in exercise training, and concerns for individuals with pre-existing chronic diseases. In healthy populations, wearing a mask does not appear to cause any harmful physiological alterations, and the potentially life-saving benefits of wearing face masks seem to outweigh the documented discomforts (e.g. headaches). However, there continues to be controversy over mask wearing in the United States, even though wearing a mask appears to have only minor physiological drawbacks. While there are minimal physiological …

Covid-19_Umaine News_Umaine 4-H Centers Partner With Maine K–12 Schools To Provide Outdoor And Stem Education For Students, University Of Maine Division Of Marketing And Communications

Division of Marketing & Communications

Screenshot of Maine News release regarding the University of Maine Cooperative Extension's 4-H Learning Centers playing a pivotal role in the education plans of K-12 schools in Maine communities.

Are Pangolins Scapegoats Of The Covid-19 Outbreak-Cov Transmission And Pathology Evidence?, Siew Woh Choo, Jinfeng Zhou, Xuechen Tian, Siyuan Zhang, Shen Qiang, Stephen James O'Brien, Ka Yun Tan, Sara Platto, Klaus-Peter Koepfli, Agostinho Antunes, Frankie Thomas Sitam

Biology Faculty Articles

The COVID‐19 outbreak has infected over 6 million people across the world. The origin of COVID‐19 coronavirus (CoV) remains unknown, although pangolins have been suggested as potential hosts. We investigated two pangolins seized in Guangdong Province, China. Molecular screening revealed CoV in one pangolin (“Dahu”), while another (“Meidong”) was infected by Ehrlichia ruminantium. Dahu exhibited difficulty breathing, infections of lung, intestines, and nostrils, as revealed by computed tomography imaging and necropsy. Previous phylogenetic analyses showed bat coronavirus RaTG13 is closer to COVID‐19 CoV compared to pangolin coronavirus. Over 20 caregivers have had close physical contact with CoV‐positive Dahu, but …

Covid-19_Umaine News_Marble Talks With Daily Bulldog About Virtual Fair, University Of Maine Division Of Marketing And Communications

Division of Marketing & Communications

Screenshot of UMaine in the News regarding Tara Marble, University of Maine Cooperative Extension 4-H Youth development professional talking with Daily Bulldog about their virtual fair

Mesenchymal Stem Cells And Their Extracellular Vesicles: A Potential Game Changer For The Covid-19 Crisis, Dina H. Kassem, Mohamed M. Kamal

Pharmacy

Corona virus disease 2019 (COVID-19) is a global public health crisis. The high infectivity of the disease even from non-symptomatic infected patients, together with the lack of a definitive cure or preventive measures are all responsible for disease outbreak. The severity of COVID-19 seems to be mostly dependent on the patients’ own immune response. The over-activation of the immune system in an attempt to kill the virus, can cause a “cytokine storm” which in turn can induce acute respiratory distress syndrome (ARDS), as well as multi-organ damage, and ultimately may lead to death. Thus, harnessing the immunomodulatory properties of mesenchymal …