Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
-
- Microbiome (2)
- Animal tissue (1)
- Antimicrobial activity (1)
- Bacterial infection (1)
- Bile (1)
-
- Cellular targets (1)
- Clinical manifestation (1)
- Compositional (1)
- Computational biology (1)
- Controlled study (1)
- Epigallocatechin gallate (1)
- Gastrointestinal tract (1)
- Gene sequence (1)
- Gram-positive (1)
- Host-pathogen interactions (1)
- Immune response (1)
- Lake (1)
- Lipid metabolism (1)
- Listeria (1)
- Lubomirskia baicalensis (1)
- Matrix completion (1)
- Membrane association (1)
- Metagenomics (1)
- Microbial community (1)
- Microbial diversity (1)
- Microbial ecology (1)
- Microbial evolution (1)
- Mortality (1)
- Neuroinvasion (1)
- Nonhuman (1)
Articles 1 - 8 of 8
Full-Text Articles in Life Sciences
The Antimicrobial Activity And Cellular Pathways Targeted By P-Anisaldehyde And Epigallocatechin Gallate In The Opportunistic Human Pathogen Pseudomonas Aeruginosa, Yetunde Adewumni, Sanchirmaa Namjilsuren, William D. Walker, Dahlia N. Amato, Douglas V. Amato, Olga V. Mavrodi, Derek L. Patton, Dmitri V. Mavrodi
The Antimicrobial Activity And Cellular Pathways Targeted By P-Anisaldehyde And Epigallocatechin Gallate In The Opportunistic Human Pathogen Pseudomonas Aeruginosa, Yetunde Adewumni, Sanchirmaa Namjilsuren, William D. Walker, Dahlia N. Amato, Douglas V. Amato, Olga V. Mavrodi, Derek L. Patton, Dmitri V. Mavrodi
Faculty Publications
Plant-derived aldehydes are constituents of essential oils that possess broad-spectrum antimicrobial activity and kill microorganisms without promoting resistance. In our previous study, we incorporated p-anisaldehyde from star anise into a polymer network called PANDAs (Pro-Antimicrobial Networks via Degradable Acetals) and used it as a novel drug delivery platform. PANDAs released p-anisaldehyde upon a change in pH and humidity, and controlled growth of the multi-drug resistant pathogen Pseudomonas aeruginosa PAO1. In this study, we identified cellular pathways targeted by p-anisaldehyde, by generating 10,000 transposon mutants of PAO1 and screened them for hypersensitivity to p-anisaldehyde. To improve the …
Analysis Of The Cody Rnome Reveals Rsad As A Stress-Responsive Riboregulator Of Overflow Metabolism In Staphylococcus Aureus, Yoann Augagneur, Alyssa N. King, Noëlla Germain-Amiot, Mohamed Sassi, John W. Fitzgerald, Gyan S. Sahukhal, Mohamed O. Elasri, Brice Felden, Shaun R. Brinsmade
Analysis Of The Cody Rnome Reveals Rsad As A Stress-Responsive Riboregulator Of Overflow Metabolism In Staphylococcus Aureus, Yoann Augagneur, Alyssa N. King, Noëlla Germain-Amiot, Mohamed Sassi, John W. Fitzgerald, Gyan S. Sahukhal, Mohamed O. Elasri, Brice Felden, Shaun R. Brinsmade
Faculty Publications
In Staphylococcus aureus, the transcription factor CodY modulates the expression of hundreds of genes, including most virulence factors, in response to the availability of key nutrients like GTP and branched‐chain amino acids. Despite numerous studies examining how CodY controls gene expression directly or indirectly, virtually nothing is known about the extent to which CodY exerts its effect through small regulatory RNAs (sRNAs). Herein, we report the first set of sRNAs under the control of CodY. We reveal that staphylococcal sRNA RsaD is overexpressed >20‐fold in a CodY‐deficient strain in three S. aureus clinical isolates and in S. epidermidis. …
Current Understanding Of West Nile Virus Clinical Manifestations, Immune Responses, Neuroinvasion, And Immunotherapeutic Implications, Fengwei Bai, E. Ashley Thompson, Parminder J.S. Vig, A. Arturo Leis
Current Understanding Of West Nile Virus Clinical Manifestations, Immune Responses, Neuroinvasion, And Immunotherapeutic Implications, Fengwei Bai, E. Ashley Thompson, Parminder J.S. Vig, A. Arturo Leis
Faculty Publications
West Nile virus (WNV) is the most common mosquito-borne virus in North America. WNV-associated neuroinvasive disease affects all ages, although elderly and immunocompromised individuals are particularly at risk. WNV neuroinvasive disease has killed over 2300 Americans since WNV entered into the United States in the New York City outbreak of 1999. Despite 20 years of intensive laboratory and clinical research, there are still no approved vaccines or antivirals available for human use. However, rapid progress has been made in both understanding the pathogenesis of WNV and treatment in clinical practices. This review summarizes our current understanding of WNV infection in …
Parasitic Microbiome Project: Grand Challenges, Nolwenn M. Dheilly, Joaquín Martínez Martínez, Karyna Rosario, Paul J. Brindley, Raina N. Fichorava, Jonathan Z. Kaye, Kevin D. Kohl, Laura J. Knoll, Julius Lukeš, Susan L. Perkins, Robert Poulin, Lynn Schriml, Luke R. Thompson
Parasitic Microbiome Project: Grand Challenges, Nolwenn M. Dheilly, Joaquín Martínez Martínez, Karyna Rosario, Paul J. Brindley, Raina N. Fichorava, Jonathan Z. Kaye, Kevin D. Kohl, Laura J. Knoll, Julius Lukeš, Susan L. Perkins, Robert Poulin, Lynn Schriml, Luke R. Thompson
Faculty Publications
No abstract provided.
Establishment Of Listeria Monocytogenes In The Gastrointestinal Tract, Morgan L. Davis, Steven C. Ricke, Janet R. Donaldson
Establishment Of Listeria Monocytogenes In The Gastrointestinal Tract, Morgan L. Davis, Steven C. Ricke, Janet R. Donaldson
Faculty Publications
Listeria monocytogenes is a Gram positive foodborne pathogen that can colonize the gastrointestinal tract of a number of hosts, including humans. These environments contain numerous stressors such as bile, low oxygen and acidic pH, which may impact the level of colonization and persistence of this organism within the GI tract. The ability of L. monocytogenes to establish infections and colonize the gastrointestinal tract is directly related to its ability to overcome these stressors, which is mediated by the efficient expression of several stress response mechanisms during its passage. This review will focus upon how and when this occurs and how …
Host Lipids In Positive-Strand Rna Virus Genome Replication, Zhenlu Zhang, Guijuan He, Natalie A. Filipowicz, Glenn Randall, George A. Belov, Benjamin G. Kopek, Xiaofeng Wang
Host Lipids In Positive-Strand Rna Virus Genome Replication, Zhenlu Zhang, Guijuan He, Natalie A. Filipowicz, Glenn Randall, George A. Belov, Benjamin G. Kopek, Xiaofeng Wang
Faculty Publications
Membrane association is a hallmark of the genome replication of positive-strand RNA viruses [(+)RNA viruses]. All well-studied (+)RNA viruses remodel host membranes and lipid metabolism through orchestrated virus-host interactions to create a suitable microenvironment to survive and thrive in host cells. Recent research has shown that host lipids, as major components of cellular membranes, play key roles in the replication of multiple (+)RNA viruses. This review focuses on how (+)RNA viruses manipulate host lipid synthesis and metabolism to facilitate their genomic RNA replication, and how interference with the cellular lipid metabolism affects viral replication.
Diversity And Shifts Of The Bacterial Community Associated With Baikal Sponge Mass Mortalities, Sergei Belikov, Natalia Belkova, Tatiana Butina, Lubov Chernogor, Alexandra Martynova-Van Kley, Armen Nalian, Colin Rorex, Igor Khanaev, Olga Maikova, Sergey Feranchuk
Diversity And Shifts Of The Bacterial Community Associated With Baikal Sponge Mass Mortalities, Sergei Belikov, Natalia Belkova, Tatiana Butina, Lubov Chernogor, Alexandra Martynova-Van Kley, Armen Nalian, Colin Rorex, Igor Khanaev, Olga Maikova, Sergey Feranchuk
Faculty Publications
The disease of freshwater sponges was first discovered in 2011, when pink samples were found in the Central Basin of Lake Baikal. Subsequently, the visible signs of the disease have changed, and now sponges appear with various symptoms of damage to the body, such as discoloration, tissue necrosis, the formation of brown patches and dirty-purple biofilms on some branches. These signs of the disease are accompanied by the mass death of sponges. We identified differences in microbiomes by sequencing 16S rRNA genes and found changes in the consortium of microorganisms of freshwater Baikal sponges. We found that the observed imbalance …
A Novel Sparse Compositional Technique Reveals Microbial Perturbations, Cameron Martino, James T. Morton, Clarisse A. Martoz, Luke R. Thompson, Anupriya Tripathi, Rob Knight, Karsten Zengler
A Novel Sparse Compositional Technique Reveals Microbial Perturbations, Cameron Martino, James T. Morton, Clarisse A. Martoz, Luke R. Thompson, Anupriya Tripathi, Rob Knight, Karsten Zengler
Faculty Publications
The central aims of many host or environmental microbiome studies are to elucidate factors associated with microbial community compositions and to relate microbial features to outcomes. However, these aims are often complicated by difficulties stemming from high-dimensionality, non-normality, sparsity, and the compositional nature of microbiome data sets. A key tool in microbiome analysis is beta diversity, defined by the distances between microbial samples. Many different distance metrics have been proposed, all with varying discriminatory power on data with differing characteristics. Here, we propose a compositional beta diversity metric rooted in a centered log-ratio transformation and matrix completion called robust Aitchison …