Life Sciences Commons^™

What Is The Best Treatment For Osteoporosis?, Joshua Sodden

The Science Journal of the Lander College of Arts and Sciences

Osteoporosis is a bone disease that leads to frail bones, caused by osteoclasts destroying more bone than osteoblasts can create. It is more common among elderly people due to a lack of growth factors that promote osteoblasts. Estrogen plays a very important role in bone homeostasis of women; therefore post-menopausal women are most commonly affected because of their lack of estrogen production. Currently the FDA has approved eleven different drug treatments for osteoporosis. These treatments include anabolic treatments such as parathyroid hormone and anti-sclerostin, as well as catabolic treatments which include bisphosphonates, estrogen hormone, SERMs and anti-RANKL. This paper describes …

The Efficiency Of Toltrazuril, Thymol, And Toltrazuril + Thymol Combination On Eimeriosis In Lamb, Mehmet Özüi̇çli̇, Ahmet Onur Gi̇ri̇şgi̇n, İhsan Kisadere, Ali̇ İhsan Di̇ker, Ali̇ Erdi̇ Candar, Levent Aydin

Turkish Journal of Veterinary & Animal Sciences

This study aimed to evaluate and compare the efficacy of the treatment with a single dose of toltrazuril 5% (Baycox), thymol (Versatile, Nine Life, United Arab Emirates), and toltrazuril + thymol combination to control Eimeria spp. infection in lambs in intensive feeding. The study was designed with five groups and these groups aligned as; group 1 (negative control group; NEG), group 2 (positive control group; POZ), group 3 (thymol; THY), group 4 (toltrazuril; TOL) and group 5 [(thymol + toltrazuril; (THY + TOL)]. Each group consisted of 26 Merino lambs which are 60-75 days old each. Treatment groups were administered …

Rgs1 Serves As An Anti-Tumor Target To Inhibit Proliferation Of Nicn87-Dr Cells And Tumor Growth In Gastric Cancer Mouse Model, Zhixiong Chen, Banglun Liu, Shouru Zhang, Lihui Chen, Yuyu Lv, Hao Sun

Turkish Journal of Biology

Gastric cancer is becoming the 4th leading cause of cancer-associated death worldwide. The purpose of this study was to investigate the role of RGS1 in gastric cancer in vitro and in vivo. Proliferation, migration, invasion, and colony formation of NCIN87 cells and drug-resistant NCIN87 cells (NCIN87-DR) were determined. Cell apoptosis and cell cycle were examined using a flow cytometry assay. RGS1 gene knock-down vector (pLVshshRGS1) and Xenograft tumor mouse model was generated. RGS1 and epithelial-mesenchymal transition (EMT) associated markers, including E-cadherin (E-cad), N-cadherin (N-cad), Slug, and Vimentin were detected using a western blotting assay. Tumor size of Xenograft tumor mouse …

Dermatology Technique: Mohs Micrographic Surgery, Michelle J. Volis

Mako: NSU Undergraduate Student Journal

This paper aims to educate the readers about a novel surgery approach that is becoming popular among dermatologists. This technique, Mohs surgery, is implemented in order to treat malignant skin cancer types. This paper incorporates the history of Mohs micrographic surgery, the advantages and disadvantages of the procedure, and alternatives to this approach. The main advantage is healthy tissue preservation while disadvantages include holes in fragmented tissue margins and tissue orientation complications.

العلاج بالعطور : نظرة علمية ورؤية شرعية, مهند الجزار

Hebron University Research Journal-A (Natural Sciences) - (مجلة جامعة الخليل للبحوث- أ (العلوم الطبيعيه

The scientific outlook for the use of alternative medicine in treatment of diseases is in progress at both medical and public levels. This is due to the fact that this type of medicine is cheaper, easy to use and has little side effects compared to conventional medicine. As a branch of alternative medicine, aromatherapy is considered as the most developing one because of its positive physiological and psychological effects on human’s health and for its simple application in clinics, hospitals, houses, and work places. This study provides an accurate review about aromatherapy from scientific and Islamic point of view. The …

The Formation And Manifestation Of Kidney Stones, Adina Peikes

The Science Journal of the Lander College of Arts and Sciences

Conclusion:

As more research is done on kidney stones it becomes abundantly clear that even more research is needed. There are an innumerable amount of factors to take into account when determining the best course of treatment for persons with renal calculi. The patient’s occupation, ethnicity, BMI, family history, and region of residence are all contributing aspects. Stone composition may be very varied from case to case. Treatment that was successful for one may be detrimental for the other. There is no one-size-fits-all solution. Each case is unique and requires its own analysis and diagnosis. One thing is universal though, …

Which Hypothesis Best Explains The Development Of Cancer?, Ariel M. Mayer

The Science Journal of the Lander College of Arts and Sciences

There are three theories of cancer development analyzed in this review. The first theory is the immunological theory, which states that cancer is a result of the immune system failing to detect a cancerous cell in which results in uncontrolled cell growth. The second theory is the somatic mutation theory, which states that genetic mutations are a direct cause cancer. The third theory is the stem cell theory which states that cancer results from an uncontrolled stem cell. The difference in each theory helps guide a clinician’s judgment in how to treat cancer. If a clinician believes in the immunological …

Effects Of Aerobic Exercise Modality On Cognition And Fitness In Breast Cancer Survivors, Julie A. Larsen, Judy Knuth

International Journal of Exercise Science

International Journal of Exercise Science 12(3): 1023-1033, 2019. Although cognitive dysfunction is a common occurrence among breast cancer survivors, there is no widely recognized intervention for this debilitating condition. The purpose of this study was to determine whether floor/step aerobics (FSA) and/or treadmill walking (TMW) interventions can improve outcomes when compared to standard care (STC). Recent breast cancer survivors participated in 12 weeks of FSA (n=8), TMW (n=7), or STC (n=10) with pre/post assessments of cognition and fitness. Interaction effects between group and time were assessed with repeated measures ANOVA. Throughout the extent of …

Prion Diseases: Causes, Symptoms, And Treatments

D.U.Quark

Prions are pathogenic molecules which cause prion proteins, found abundantly in the brain, to fold improperly. In the following review, I will discuss the source of prions and the fundamental biochemical pathways which cause the prion proteins to misfold. I will also elucidate the factors that determine which form of disease the prions differentiate into. Prion diseases include Creutzfeldt-Jakob Disease, Bovine Spongiform Encephalopathy, and Fatal Familial Insomnia. This discussion will also analyze various benchmarks in brain atrophy and symptoms by which the progression can be judged. The survival rate of prion diseases is zero percent, and current treatments only temporarily …

Snake Envenomation In Two Cattle: Clinical/Laboratory Aspects And Treatment Using Equine-Derived Antivenin Of Viperidae, Nuri̇ Altuğ, Cafer Tayer İşler

Turkish Journal of Veterinary & Animal Sciences

In this case report, specific antivenin treatment for Viperidae snake envenomation in two cattle was defined for the first time. The diagnosis of snake envenomation was made according to the history and clinical findings. Clinical examination revealed systemic (tachycardia, dyspnea, cyanosis, hypersalivation, ruminal hypotony) and local (swelling of the leg and head) findings depending on the location of snake bites. Laboratory analysis determined granulocytic leukocytosis, monocytosis, decreased iron binding capacity, and increased CK and LDH enzyme activities. In the specific treatment of cases, equine-derived polyvalent antivenin containing antitoxic immunoglobulins against Viperidae species was administered. Additionally, 5% dextrose, antibiotics, dexamethasone, antihistamines, …

Should Subclinical Hypothyroidism Be Treated?, Rachel Kaufman

The Science Journal of the Lander College of Arts and Sciences

Subclinical Hypothyroidism, SCH, has been detected with increasing frequency in recent years and has brought about major controversies regarding management and treatment [Meier et al., 2001]. The condition is characterized as having a high concentration of thyroid stimulating hormone, yet normal thyroid hormone levels and is often asymptomatic. Scientific articles retrieved from various databases helped determine some of the long term risk factors associated with SCH, including progression to overt hypothyroidism, fatty liver disease, cardiovascular disease, neuropsychiatric complications and reproductive malfunctions. Studies determining the clinical and metabolic effects of L-thyroxine hormone replacement therapy on symptoms and potential risks of SCH …

Impact Of Physical Activity On Type 2 Diabetes Mellitus, Marshall Schwartz

The Science Journal of the Lander College of Arts and Sciences

Type 2 diabetes mellites has become an increasingly prevalent worldwide epidemic. The tremendous economic burden, coupled with the numerous secondary risks associated with the disease, have encouraged researchers to search for causes as well as treatment methods. This research paper focuses on the effect of physical activity as a preventative measure for those at risk for diabetes and as a treatment method for those already diagnosed with the disease. The articles collected included meta-analysis, randomized controlled trials, cohort studies, surveys, etc. The studies that were analyzed have indicated an inverse relationship between physical activity and type 2 diabetes. Since there …

Endorphins, Endocannabinoids And Runners’ High, Elisheva Winiarz

The Science Journal of the Lander College of Arts and Sciences

Modern science takes at face value the fact that exercise is beneficial for man’s health. In recent years, medical health professionals have begun to harness exercise as a treatment for a broader range of maladies. Since various studies found increased exercise to correlate with higher levels of endorphins, most believed that the endorphins were directly responsible for what the vernacular dubbed “Runner’s High.” Scientists have sought to either augment or wholly disprove the endorphin hypothesis with further studies. Major Depressive Disorder, or MDD, is an affective condition affecting a significant portion of the general population. Aerobic exercise is increasingly being …

Exercise Can Potentially Cure Parkinson’S Disease: A Comprehensive Review, Ilana Tokarsky

The Science Journal of the Lander College of Arts and Sciences

Parkinson’s disease is the second most common neurodegenerative disease that negatively affects many American lives. It is characterized by the degeneration of dopamine-secreting neurons in the Substantia Nigra Pars Compacta (SNpc). Individuals with Parkinson’s Disease lack motor coordination and experience severe motor impairments. Unfortunately, there is currently no treatment method available that can successfully cure the disease. In fact, all of the mainstream available treatments only eliminate some PD symptoms, and they cause many negative side effects. Although nontraditional, exercise is a side effect free treatment method that can potentially slow the progression of the disease and alleviate some symptoms. …

Treatment And Management Of Idiopathic Thrombocytopenic Purpura (Itp) In A Collegiate Football Player, Angela Talaganis, Jordan Kocher

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

In Volume 3, Issue 1 of the JSMAHS you will find Professional research abstracts, as well as Under Graduate student research abstracts, case reports, and critically appraised topics.

Thank you for viewing this 3^rd Annual OATA Special Edition.

Patellar Dislocation: A Deeper Look At Various Knee Pathologies In Young Female Athletes, Cade Coulter

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

In Volume 3, Issue 1 of the JSMAHS you will find Professional research abstracts, as well as Under Graduate student research abstracts, case reports, and critically appraised topics.

Thank you for viewing this 3^rd Annual OATA Special Edition.

Fibroblast Proliferation In Response To Treatment By A Novel Tgf-Beta Pathway Inhibitor, Coray Preece, Robert Hyldahl

Journal of Undergraduate Research

Fibroblasts play a key role in repairing injured tissue by secreting collagen and growth factors into the tissue. In states of disease and overuse, fibroblast activity (i.e. greater fibroblast content and collagen secreting activity) can lead to skeletal muscle fibrosis, in which myofibers are replaced by collagen, decreasing strength and muscle elasticity. It has been shown in previous studies that TGF-beta signaling directly increases fibroblast proliferation and collagen secretion. It has also been shown that inhibition of TGF-beta signaling reduces known symptoms of muscular dystrophies including decreased fibrosis and increased muscular strength. SGI-1252 is a novel small molecule that our …

First Clinical Strongyloides Stercoralis Case In A Dog In Turkey, Şi̇nasi̇ Umur, Yücel Meral, Cenk Soner Bölükbaş, Ali̇ Tümay Gürler, Mustafa Açici

Turkish Journal of Veterinary & Animal Sciences

A 2.5-year-old small male Cavalier King Charles spaniel was brought to Ondokuz Mayıs University's Faculty of Veterinary Medicine Animal Hospital with symptoms of severe watery diarrhea, pain during defecation, intermittent cough, vomiting, and emaciation. Examination of the fecal smear revealed moderate infection of Strongyloides stercoralis larvae and two adult females. Counting of the larvae in feces was performed by Baermann method and 20 larvae were determined per gram of feces. The dog was treated with ivermectin (Avromec, 0.2 mg/kg subcutaneously) and multivitamin syrup (Vitabiol) for 5 days for supporting the body condition. This paper is the first clinical case report …

The Treatment Of Supracondylar And Diaphyseal Femoral Fractures Incats Using Intramedullary Two-Way Stacked Kirschner Wire Application, Kemal Altunatmaz, Murat Karabağli, Di̇dar Aydin, Özlem Güzel, Ebru Eravci Yalin, Ümi̇t Uğurlu, Defne Joan Şadalak, Hi̇mmet Eki̇ci̇

Turkish Journal of Veterinary & Animal Sciences

Femoral fractures in cats are treated using pin and wires, lag screws, Rush pins, intramedullary threaded pins, interlocking pins, clamp rod internal fixators, and plates or plate-rods. In this study, 14 cats brought to the surgery clinic between the years 2010 and 2015 for fracture, due to either a road traffic accident or falling from a height, were evaluated. Following clinical and radiological examination of the cases, the type and location of the fracture, details of the applied fixation method, and postoperative clinical and radiological results were assessed. Localization of the fractures was as follows: 4 comminuted diaphyseal (1 segmental), …

Treating Cocaine Dependency With Psychopharmacotherapy And Behavioral Therapy, Robyn Liebman

e-Research: A Journal of Undergraduate Work

Cocaine is an addictive drug that affects more than 14 million people globally, according to the United Nations. This paper is a conceptual meta-analysis of numerous studies that tested the effects of psychopharmacological therapy along with behavioral therapy in the treatment of cocaine addiction. It is hypothesized that cocaine dependent individuals treated with a combination of psychopharmacological and behavioral therapies will be less likely to use cocaine. Measurements of cocaine use throughout the experiments were generally assessed by urine screenings. Results indicate that there is more evidence that a combination of psychopharmacological and behavioral therapies will reduce cocaine use. There …

The Treatment Of Mental Disorders Through Medication, Jessica Jaynes

Sound Neuroscience: An Undergraduate Neuroscience Journal

Diagnosis plays a huge role in the successful treatment of mental disorders. Subtle differences in symptoms can lead to different diagnoses, and therefore different prescribed medications. The neurological causes of anxiety, depression, bipolar disorder, and ADHD are examined; as well as the mechanisms of the drugs commonly used to treat them.

Fractures In Young, Single-Humped Camels (Camelus Dromedarius), Ahmed F. Ahmed, Fahd Abdullah Al-Sobayil

Turkish Journal of Veterinary & Animal Sciences

The objectives were to study the frequencies and classification of fractures in young camels and to evaluate the clinical relevance of external fixation as a method of treatment. Cases of fractures (n = 75) in young camels (less than 2 years old) were studied. On admission, the cause, site, classification, and radiography of the fractures as well as the methods of treatment were investigated. Factors affecting fracture healing after treatment were investigated and analyzed. The frequencies of fracture were affected by breed (P = 0.001) and age (P = 0.01) but not sex. Trauma was the most common cause of …

Massive Toxoplasma Abortions In A Dairy Sheep Flock And Therapeutic Approach With Different Doses Of Sulfadimidine, Nektarios D. Giadinis, Konstantinos Terpsidis, Anastasia Diakou, Victoria Siarkou, Panayiotis Loukopoulos, Ridvan Osman, Harilaos Karatzias`, Margarita Papazahariadou

Turkish Journal of Veterinary & Animal Sciences

In a 500 head dairy sheep flock in Northern Greece, massive abortions (60%) were observed at 110-130 days of gestation. Attempts were made to treat the abortions with oxytetracyclin L.A. 20% but they were not successful. Toxoplasmosis was confirmed by laboratory examination of blood sera of ewes, aborted fetuses, and fetal brain samples. The remaining 200 pregnant sheep were divided in 2 groups of 100 ewes each. Animals of Group 1 were treated with 20 mg/kg b.w. sulfadimidine every other day 4 times, while the animals in Group 2 received 33 mg/kg b.w. sulfadimidine every other day 4 times via …

Repeat Breeder Syndrome In Dairy Cows: Influence Of Breed And Age On Its Prevalence And The Success Of A Hormone Therapy*, Robert Zobel, Suzana Tkalcic, Vlatka Buic, Ivana Pipal, Darko Geres, Marko Samardzija

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to establish the prevalence of repeat breeder syndrome (RBS) in different breeds and reproductive ages of cattle in central Croatia and to assess the effectiveness of hormone therapy as a treatment option. A total of 1088 dairy cows were observed, 218 heifers and 870 multiparous cows. After the third unsuccessful artificial insemination (n = 164) and a thorough clinical and gynecological examination, the cows were tested for sexually transmitted diseases. An RBS diagnosis was based on failure to conceive, negative laboratory tests for sexually transmitted diseases, and the absence of other reproductive disorders. The …

Nasal Squamous Cell Carcinoma In A Cow, Ali Baniadam, Navid Moezzi, Babak Mohammadian

Turkish Journal of Veterinary & Animal Sciences

A patient with a turgid, hemorrhagic mass infected by myiasis in the left nostril and diagnosed as squamous cell carcinoma (SCC) is presented. Complete blood count (CBC) showed moderate neutrophilia and eosinophilia and vital signs were in normal range. After aseptic surgical preparations and local anesthesia, the mass removed en bloc and submitted to the Department of Veterinary Pathology for histopathological evaluation. SCC was recognized microscopically by identifying malignant epithelial cells demonstrating various degrees of differentiation towards keratinocytes.

Haemobartonellosis In Van Cats, Hasan Altan Akkan, Mehmet Karaca, Mehmet Tütüncü, Nalan Özdal, Nazmi̇ Yüksek, Zahi̇d Ağaoğlu, Serdar Değer

Turkish Journal of Veterinary & Animal Sciences

The present study was conducted to determine prevalence of Haemobartonella felis in Van cats. 121 Van cats (82 female, 39 male, aged 1-9 years) were the materials of the study. To determine biochemical and haematological parameters, 2 ml blood with and without anticoagulant were taken according to technique from vena cephalica antebrachii. H. felis was detected in blood smears preparations of 18 (14.88%) by Papenheim staining. Among biochemical parameters aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), creatine phosphokinase (CPK) and bilirubin were in normal range as well as the packed cell volume (PCV) and red blood …

The Treatment Of Experimental Acute Ethylene Glycol (Antifreeze) Toxication Using 4-Methyl Pyrazol And Ethanol In Dogs, Vehbi̇ Güneş, Çeti̇nkaya Şendi̇l

Turkish Journal of Veterinary & Animal Sciences

The effects of ethanol and 4-methyl pyrazole were investigated in the treatment of 30 dogs toxicated with antifreeze (AF). The AF toxication produced significant increases in blood urea, creatinin and potassium and a decrease in blood calcium levels. Calcium-oxalate monohydrate, which is pathognomic for AF toxication, was consistently seen in urine sediment. Ethanol was rarely effective on the multisystemic effects that occurred in dogs or ADH inhibition. CNS findings were also observed after ethanol administration. The results indicated that 4-MP treatment provided earlier and safer healing than ethanol. It was deduced that 4-MP + NaHCO_3 was more effective than ethanol …

Natural Ovine Dermatophilosis: Clinical Aspects And Efficacy Of Penicillin/Streptomycin Treatment, Servet Seki̇n, Özgül Mukaddes Eli̇tok, Bülent Eli̇tok, Adnan Suay

Turkish Journal of Veterinary & Animal Sciences

This is the first report about natural Dermatophilus congolensis infection in Turkey. Presumptive and confirmatory diagnoses were made based on clinical signs and the demonstration of the bacteria frorn scab material by direct microscopic examination and by culturing the organism on bacteriological media and identifying it by conventional methods such as biochemical reactions. The study was carried out using two groups of animals. Seventy sheep and 20 goats, 8-11 months old were included in group 1 and 155, 1-4 weeks old lambs in group 2. Ten sheep and five goats in the first group and 10 lambs in the second …

A Case Of Aelurostrongylus Abstrusus Infection In A Cat In İstanbul, Turkey And Its Treatment With Moxidectin And Levamisole, Erkut Tüzer, Müfi̇t Toparlak, Ayşen Gargili, Vedat Keleş, Meltem Ulutaş Esatgi̇l

Turkish Journal of Veterinary & Animal Sciences

Larvae of Aelurostrongylus abstrusus were identified in the feces of a 2-year-old female cat suffering from dyspnea and incoordination for 18 months. The larvae had a terminal S-shaped projection and a subterminal dorsal spine. The larvae measured 363-378x15 µm (aver. 370x15 µm). Firstly, moxidectin (0.4 mg/kg) was given subcutaneously to 3 healthy stray cats over 1 year old to check adverse effects on cats. No adverse reaction was observed. Then a subcutaneous injection of moxidectin (0.4 mg/kg) was given to the infected cat for treatment on day 0 and this was repeated on day 51. Seventy-nine days after the 2nd …

Clinical And Laboratory Studies In Four Goats With Leptospirosis Out Of A Herd Of Goats, Murat Dabak, Yusuf Gül, Ömer Kizil, Vi̇ldan Özdemi̇r

Turkish Journal of Veterinary & Animal Sciences

Four male goats aged 10-12 months showing clinical signs of leptospirosis out of a herd of 90 goats in the province of Elazığ were used in this study. Having performed a systematic clinical examination of the sick animals, blood samples were taken from v. jugularis for heamatological (total leucocytes, erythrocytes, haemoglobin and PCV), biochemical (blood glucose, plasma proteins, albumin, globulin, total, direct and indirect bilirubin, aspartate amino transferase, urea and creatinin) and serological (microscopic agglutination test, MAT) analysis. Intramuscular penicillin+streptomycine, subcutaneous 40% urotropin solution and oral ammonioum chloride were administered daily. Two of the sick animals died while the other …