Life Sciences Commons^™

Autoantibodies To The Ny-Eso-1 Tumor Antigen In Metastatic Melanoma: Sialylation Of The Fc Region Of Immunoglobulin G Induces Differential Expression Signatures Of Inflammatory Molecules During Dendritic Cell Differentiation And Maturation, Martin Oaks, Nathaniel Rein, John O. Richards, James Shaffer

Journal of Patient-Centered Research and Reviews

Purpose: We tested the hypothesis that different glycoforms of antibodies from patients with metastatic melanoma have different functional effects on human dendritic cell differentiation and maturation.

Methods: Antibodies to the cancer antigen NY-ESO-1 were affinity-purified from patients with melanoma and further fractionated into different glycoforms by lectin chromatography. Sialic acid-rich and sialic acid-poor fractions of these immunoglobulin G antibodies (IgG) were added to dendritic cell cultures during both differentiation and maturation, and the resulting cellular messenger RNA (mRNA) and culture supernatants were tested by microarray and enzyme-linked immunoassay for molecules related to inflammatory pathways.

Results: We identified unique mRNA and …

Human Papillomavirus And The Gardasil Vaccine: Medicalization And The Gendering Of Bodies And Bodily Risk, Lauren Camara

Laurier Undergraduate Journal of the Arts

No abstract provided.

Survey Of The Ectoparasites Of The Invasive Small Indian Mongoose (Herpestes Auropunctatus [Carnivora: Herpestidae]) On St. John, U.S. Virgin Islands, Kelsey L. Townsend, Karen E. Powers

Virginia Journal of Science

In March 2012, live trapping surveys were conducted for invasive small Indian mongoose (Herpestes auropunctatus) on St. John, U.S. Virgin Islands. Forty mongoose were sampled (31%, 9&) for ectoparasites, and cat fleas (Ctenocephalides felis) were discovered on 17 individuals. There was no difference in the number of ectoparasites per mongoose across age classifications (r = 0.109, P = 0.579). However, males had more cat fleas than females, even when mass was taken into account (males are generally heavier). Future behavioral studies may explain these sex differences. Although management suggestions from this research are limited, these …

The Hot Zone And The Cold War, Peter Nichols

Colby Magazine

It was a time when, in the nation's schools, drills for nuclear war were as frequent as fire drills- when Americans and their Soviet counterparts lived with a constant fear of imminent worldwide destruction. "You had a cultural mindset that was apocalyptic," said Robert S. Weisbrot, Christian A. Johnson Distinguished Teaching Professor of History at Colby, "that believed you could not guarantee that your wonderful suburban home and family and community...would survive ten more seconds."

"It was not simply a matter of two countries that are adversaries building up weapons," said Weisbrot. "Each saw the other as the incarnation of …

Maine’S Contested Waterfront: The Project To Remake Sebago Lake’S Lower Bay, 1906-1930, David B. Cohen

Maine History

Throughout the nation’s history, few resources have been considered as ubiquitous as water. The issue of who controls the use of water, however, has seldom been straight forward. This was no less true in the Progressive Era, when many growing urban areas significantly altered their water infrastructure to meet increased demands. When debate arose over water use, these municipalities often relied on the relatively new authority of scientific knowledge, particularly in the area of public health and safety. In this article, the author describes how the Portland Water District was able to conserve Sebago Lake’s Lower Bay as a clean, …

Fty720 (Fingolimod) Provides Insight Into The Molecular Mechanisms Of Multiple Sclerosis, Madelyn Elizabeth Crawford

Pursuit - The Journal of Undergraduate Research at The University of Tennessee

Multiple sclerosis (MS) is a neurodegenerative disorder caused by a prolonged immune- mediated inflammatory response that targets myelin. Nearly all of the drugs approved for the treatment of MS are general immunosuppressants or only function in symptom management. The oral medication fingolimod, however, is reported to have direct therapeutic effects on cells of the central nervous system in addition to immunomodulatory functions. Fingolimod is known to interact with sphingosine-1-phosphate (S1P) receptors, and the most widely- accepted theory for its mechanism of action is functional antagonism of the receptor. This review examines significant neuromodulatory effects achieved by functional antagonism of the …

Analysis Of The Morbidity And Mortality Of Severe Influenza Infection In Clark County, Nevada For The 2010-2011 Influenza Season, Kindra St. Jacques, Patricia Cruz, Brian Labus

Nevada Journal of Public Health

Throughout the duration of any influenza season, influenza strains have the ability to evolve through mutation causing alterations in virulence. These changes may result in severe illness or death among susceptible populations; therefore, it is important to closely monitor influenza-associated hospitalizations and deaths. The University of Nevada, Las Vegas in collaboration with the Southern Nevada Health District analyzed data from the hospitalized influenza morbidity and mortality surveillance project for Clark County for the 2010-2011 influenza season. Among the study population (N= 158): the influenza strain type was found to be significantly associated with deaths (n= 25), vaccination status was not …

Post-Apartheid South Africa’S Ultimate Challenge, Nahomie Julien

DISCOVERY: Georgia State Honors College Undergraduate Research Journal

Throughout time, South Africa has experienced many upheavals, be they slavery and apartheid or natural, socioeconomic, and political misfortunes.Just after overcoming the oppression of Apartheid, South Africans have to face one of the deadliest illness in the world: HIV/AIDS. HIV/AIDS is currently the number one killer in South Africa(WHO, 2012). This pandemic further worsen the struggles of the nation, obstructing its educational, financial, and political recovery (Oglethorpe, & Gelman, (2008).; Weiser, et al., 2007.). This paper seeks to analyze how apartheid—or rather, its demise—contributed to the alarmingly rapid spread of this pandemic in South Africa. In so doing, the current …