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Detection Of Inositol Polyphosphates By Polyacrylamide Gel Electrophoresis (Page) Under Apoptotic Conditions In Cultured Sw480 Cells, M. K. Zafar, R. Mohsin, S. Hassen, R. Agarwal, H. Mumtaz, N. Ali

Journal of the Arkansas Academy of Science

Inositol phosphates are naturally occurring compounds that regulate diverse cellular processes including apoptosis. Apoptosis is a mechanism by which cells undergo natural death to maintain cellular homeostasis. It causes cell death in areas during a state that is harmful to the body. It also regulates cellular development. Previous work has shown that exogenously administered, as well as endogenously manipulated inositol phosphates bring about apoptotic changes. It has been demonstrated that cellular levels of inositol phosphates, particularly higher inositol phosphates such as inositol hexakis-phosphate (IP6) and diphosphoinositol pentakis-phosphate (IP7) levels increase during apoptotic conditions. In this study, we have attempted to …