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Full-Text Articles in Life Sciences
Which Hypothesis Best Explains The Development Of Cancer?, Ariel M. Mayer
Which Hypothesis Best Explains The Development Of Cancer?, Ariel M. Mayer
The Science Journal of the Lander College of Arts and Sciences
There are three theories of cancer development analyzed in this review. The first theory is the immunological theory, which states that cancer is a result of the immune system failing to detect a cancerous cell in which results in uncontrolled cell growth. The second theory is the somatic mutation theory, which states that genetic mutations are a direct cause cancer. The third theory is the stem cell theory which states that cancer results from an uncontrolled stem cell. The difference in each theory helps guide a clinician’s judgment in how to treat cancer. If a clinician believes in the immunological …
What Are The Most Appropriate Treatments, Preventions And Family Planning Options For Patients With Factor V Leiden?, Simha Wolf
The Science Journal of the Lander College of Arts and Sciences
The management of Venous Thromboembolism in terms of treatments and prevention has been well researched for patients who have been discovered as positive for Factor V Leiden genetic clotting disorder, in either the homozygous or the heterozygous genotype. In fact, the research and development of new agents called Direct oral anticoagulants aim to treat and prevent clotting events while minimizing the risks of bleeding. Although several risk factors have been identified in relation to VTE, Factor V Leiden mutation presents a seemingly higher risk due to its unpredictable incidences of clotting events, even in patients with optimal health characteristics. Yet, …
Uvb Induced Mutation Of P53 In Non Melanoma Skin Cancer, Raizy Berger
Uvb Induced Mutation Of P53 In Non Melanoma Skin Cancer, Raizy Berger
The Science Journal of the Lander College of Arts and Sciences
There is a clear correlation between excessive sun exposure and the development of skin cancer. UVB radiation from the sun is potent, and as the ozone layer gets depleted, more UVB can reach Earth and cause cell damage. UV radiation causes DNA lesions, such as 6-4 photoproducts and cyclobutane pyrimidine dimers. Cyclobutane pyrimidine dimers are more abundant and take longer to be repaired and therefore are responsible for most of the mutation and DNA damage. These DNA lesions lead to mutation of the p53 gene. The signature mutation on p53 from UV radiation is a CC to TT mutation, which …