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Full-Text Articles in Life Sciences
The Relationship Between Autoimmunity And Polyautoimmunity, David Schon
The Relationship Between Autoimmunity And Polyautoimmunity, David Schon
The Science Journal of the Lander College of Arts and Sciences
Autoimmune disease refers to a systemic immune response by the body against its own healthy tissue and cells. This results in various non-specific and systemic inflammatory processes that evolve into more than 100 individual diseases. Numerous biological similarities exist between the different pathophysiological pathways, including biochemical cascades and inflammasome mediators. This paper aims to investigate whether contracting one form of autoimmune disease can lead to the development of polyautoimmunity and multiple autoimmune syndrome. Scientists have identified chronic levels of high stress as a contributor to higher levels of C-reactive protein and several immune modulating interleukins, which can lead to both …
The Riddle Of The Fetal Allograft, Rachel Tepper
The Riddle Of The Fetal Allograft, Rachel Tepper
The Science Journal of the Lander College of Arts and Sciences
The immunological paradox of nurturing a fetus with paternal antigens poses some perplexing questions. Peter Medawar, an immunologist, asked at a lecture, “How does the pregnant mother contrive to nourish within itself, for many weeks or months, a fetus that is an antigenically foreign body?” Researchers have since then struggled to answer this question. The research on this topic has led to a few general hypotheses that try to explain this phenomenon. The downregulation of T cells toward paternal alloantigens is an accepted hypothesis. Another hypothesis discusses the significance of the decidua and its ability to impair dendritic cells, which …
Possible Mechanisms That Protect The Fetus From Maternal Rejection, Adina Ziemba-Goldfarb
Possible Mechanisms That Protect The Fetus From Maternal Rejection, Adina Ziemba-Goldfarb
The Science Journal of the Lander College of Arts and Sciences
There is no other foreign tissue transplant that has such a strongly parasitic relationship with its human host as the fetus. Although the fetus contains paternal genes, is completely tolerized by its maternal host in almost all pregnancies. This presents an immunological paradox and has generated a lot of attention from leading researchers in the reproductive and immunology fields. This paper reviews the leading explanations for this paradox; that it is attributed to a detailed mechanism of the maternal and fetal immune system in which tryptophan suppresses T-cells from attacking specific paternal cells, while maintaining a strong immune response against …