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Full-Text Articles in Life Sciences
Effect Of Eosinophils In Purinergic Receptor P2x3 Expression In Mouse Sensory Neurons, Emily J. Mize
Effect Of Eosinophils In Purinergic Receptor P2x3 Expression In Mouse Sensory Neurons, Emily J. Mize
Student Research Symposium
P2X3 purinoceptors are expressed by airway sensory neurons and activated by extracellular ATP released during periods of cell stress. In asthma, sensitivity to ATP is increased. Airway eosinophilia, which is common in a majority of asthmatics, increases airway sensory nerve density in mice and humans. Whether eosinophils increase neuronal P2X3 expression in asthma is unknown.
P2X3 expression was quantified in vagal ganglia from wild-type (WT) mice and transgenic mice with airway eosinophilia (NJ1726), systemic eosinophilia (NJ1638), and eosinophil-deficiency (PHIL) using RNAscope in situ hybridization. Images were obtained using confocal microscopy. The percentage of P2X3 positive pixels …
Understanding The Comorbidity Of Asthma And Anxiety In Childhood: Characteristics, Vulnerabilities, And Treatment Implications, Nicole Fleischer, Elizabeth Gosch, Phil Kendall
Understanding The Comorbidity Of Asthma And Anxiety In Childhood: Characteristics, Vulnerabilities, And Treatment Implications, Nicole Fleischer, Elizabeth Gosch, Phil Kendall
Research Day
Introduction: Given the high incidence of asthma and anxiety comorbidity, clinicians should be informed of the unique presentation of these clients in clinical practice. Although much is known about the development and characteristics of childhood anxiety, less is known about children with anxiety and comorbid asthma.
Methods: This study, using archival data, examined the potential differences in children with comorbid asthma and anxiety compared to children with anxiety from a random controlled trial. These two groups were compared on negative self-talk, number of physical symptoms, parent anxiety, content of their worries, and presence of panic, generalized anxiety, and …