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Full-Text Articles in Life Sciences
Comparison Of Therapeutic Exercise Accuracy During Completion Of A Home Exercise Program Using The Exercise Tutor Versus A Written Home Exercise Program, James Flis, Riana Stanko, Megan Stang, Ann Reinthal, Deborah Espy
Comparison Of Therapeutic Exercise Accuracy During Completion Of A Home Exercise Program Using The Exercise Tutor Versus A Written Home Exercise Program, James Flis, Riana Stanko, Megan Stang, Ann Reinthal, Deborah Espy
Undergraduate Research Posters 2014
Exercise is powerful in rehabilitation and prevention of disability; however, patient adherence to home exercises is difficult, learning new movements requires a great deal of practice, and incorrectly performed exercises are ineffective or even dangerous. We have developed a system comprised of a Kinect device with wearable inertial sensors to capture, record, and process the exerciser’s movement while concurrently providing targeted feedback to guide correct exercise completion. This pilot study allowed us to perform initial testing of this system, specifically, the effectiveness of this system in improving exercise accuracy, with and without the addition of inertial sensors to the Kinect …
Cholesterol Conjugated Hdac Inhibitor As Novel Anticancer Agent, Paul Orefice, Jane Peterson, Bin Sun
Cholesterol Conjugated Hdac Inhibitor As Novel Anticancer Agent, Paul Orefice, Jane Peterson, Bin Sun
Undergraduate Research Posters 2014
Histone deacetylase (HDAC) inhibitors are a class of promising new multifunctional anticancer agents. These agents are able to affect multiple epigenetic changes in aberrant cells. In addition to regulating the gene expression and transcription via chromatin remodeling, HDAC inhibitors can also modulate a variety of cellular functions including proliferation, differentiation, and apoptosis. Vorinostat (SuberAniloHydroxamic Acid, SAHA), the first HDAC inhibitor approved by FDA, inhibited the metastasis of various cancer cells. However, SAHA distributes in cancer tissue and normal tissue in a similar level. It will be ideal to selectively delivery SAHA into cancer cells. Rapidly growing cancer cells have a …
Is Steering Practice Task Dependent?, Dale Lewis, Seyed Amirhossein Hosseini, Jacqueline Jenkins
Is Steering Practice Task Dependent?, Dale Lewis, Seyed Amirhossein Hosseini, Jacqueline Jenkins
Undergraduate Research Posters 2014
A driving simulation experiment was conducted to examine the performance improvement of participants while conducting a lane keeping task and two lane changing tasks on a straight road. Forty-four participants, sixteen females and twenty-eight males, drove one of three driving conditions. The data was analyzed to test whether 1) practice is better than no practice; 2) practicing a less challenging but similar steering task is good practice for a more challenging steering task; and 3) practicing a more challenging but similar steering task is good practice for a less challenging steering task. The results indicate that practicing the more challenging …
Motor Output Structure In Targeted Aiming: A Mechanistic Model, Dale Lewis, Roger Young, Jeffrey Eder, Andrew B, Slifkin
Motor Output Structure In Targeted Aiming: A Mechanistic Model, Dale Lewis, Roger Young, Jeffrey Eder, Andrew B, Slifkin
Undergraduate Research Posters 2014
Studies using a variety of experimental tasks have established that when humans repeatedly produce an action, fluctuations in action output are highest at the lowest frequencies and fluctuation magnitude (power) systematically declines as frequency increases. Such time series structure is termed pink noise. However, the appearance of pink noise seems to be limited to tasks where action is executed in the absence of task-related feedback. A few studies have demonstrated that when action was executed in the presence of task-related feedback, power was evenly distributed across all spectral frequencies—i.e., white noise was revealed. Here, participants produced cyclical aiming movements under …
Activation Of Dna Damage Checkpoint Pathways During Skeletal Myoblast Differentiation And Apoptosis, Mofetoluwa Oluwasanmi, Greg Kliment, Crystal M. Weyman
Activation Of Dna Damage Checkpoint Pathways During Skeletal Myoblast Differentiation And Apoptosis, Mofetoluwa Oluwasanmi, Greg Kliment, Crystal M. Weyman
Undergraduate Research Posters 2014
A subset of skeletal myoblasts undergo apoptosis rather than differentiation when cultured in differentiation media (DM: absence of growth factors). While the muscle regulatory transcription factor MyoD is known to control the process of differentiation, our lab has recently discovered that MyoD is also controlling the apoptotic process in response to culture in DM by direct up-regulation of the pro-apoptotic Bcl2 family member PUMA. We similarly discovered that MyoD plays a role in the increased expression of PUMA and apoptosis in response to the DNA damaging agent, etoposide. This led to the hypothesis that culture in DM may lead to …
Fun Versus Practical: Physiological Responses And Preference Of Exercise Equipment, Shana Strunk, Courtney Perkins, Brandon Musarra, Megan O’Keefe, Katie Webb, Kenneth E. Sparks, Emily Kullman, Eddie T.C. Lam
Fun Versus Practical: Physiological Responses And Preference Of Exercise Equipment, Shana Strunk, Courtney Perkins, Brandon Musarra, Megan O’Keefe, Katie Webb, Kenneth E. Sparks, Emily Kullman, Eddie T.C. Lam
Undergraduate Research Posters 2014
The elliptical cross trainer has become a popular a mode of exercise, but can only be used indoors. The StreetStrider was designed as an outdoor elliptical-bike. PURPOSE: The purpose of this study is to determine whether the elliptical or the StreetStrider was more enjoyable, and to compare the physiological variables for energy expenditure, heart rate (HR), VO2, and Rate of Perceived Exertion (RPE). METHODS: Thirty participants (15 male, 15 female, mean age=22±2) from Cleveland State University exercised for 20 minutes at 75% of their age predicted maximal heart rate on the StreetStrider and elliptical. Energy expenditure was measured with a …
Validating Tbtif2-Interacting Candidates, Fan Wu, Jennifer Berkey, Joshua Hellsing, Nisha Thaker, Bibo Li
Validating Tbtif2-Interacting Candidates, Fan Wu, Jennifer Berkey, Joshua Hellsing, Nisha Thaker, Bibo Li
Undergraduate Research Posters 2014
Transmitted by the tsetse fly, Trypanosoma brucei is a protozoan parasite that causes sleeping sickness in human and nagana in cattle. While infecting the bloodstream and central nervous system, T. brucei evades the immune system by altering its major surface antigen, Variant Surface Glycoproteins (VSGs), which forms a thick coat on its cell membrane. The expression sites for VSGs are at the sub-telomeric regions of T. brucei chromosomes. Telomeres, DNA-protein complexes located at the end of chromosomes, provide chromosome stability by preventing degradation of the chromosome ends. The telomere complex also regulates the sub-telomeric VSG expression and switching in T. …