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Full-Text Articles in Life Sciences
Light Scattering Characterization Of Elastin-Like Polypeptide Trimer Micelles, Ilona Tsuper, Daniel Terrano, Adam Maraschky
Light Scattering Characterization Of Elastin-Like Polypeptide Trimer Micelles, Ilona Tsuper, Daniel Terrano, Adam Maraschky
Undergraduate Research Posters 2016
Elastin-Like Polypeptides (ELP) can be used to form thermo-reversible vehicles for drug delivery systems. The ELP nanoparticles are composed of three-armed star polypeptides. Each of the three arms extending from the negatively charged foldon domain includes 20 repeats of the (GVGVP) amino acid sequence. The ELP polymer chains are soluble at room temperature and become insoluble at the transition temperature (close to 50 oC), forming micelles. The size and shape of the micelle is dependent on the temperature and the pH of solution, along with the concentration of the Phosphate Buffered Saline (PBS) solvent. The technique of Depolarized Dynamic Light …
African Clawed Toads’ Responses To Visual And Lateral Line Stimuli, Marko Milosavljevic, Kevin Goth
African Clawed Toads’ Responses To Visual And Lateral Line Stimuli, Marko Milosavljevic, Kevin Goth
Undergraduate Research Posters 2016
The African Clawed Toad, Xenopus laevis, is an aquatic species commonly found throughout Sub-Saharan Africa. Adults use vision to sense movements and lateral line to sense vibrations in the water. Here, we analyze the effectiveness of the toads' vision and lateral line systems individually and in combination. This study will help us understand how Xenopus utilizes sensory information to capture prey. We tested which sensory system elicits greater responses, how stimulus angle and distance affect the probability of a response, and if the toads respond equally to visual and lateral line stimuli. We found that a combination of both visual …
Light Scattering Study Of Mixed Micelles Made From Elastin-Like Polypeptide Linear Chains And Trimers, Ilona Tsuper, Daniel Terrano, Adam Maraschky
Light Scattering Study Of Mixed Micelles Made From Elastin-Like Polypeptide Linear Chains And Trimers, Ilona Tsuper, Daniel Terrano, Adam Maraschky
Undergraduate Research Posters 2016
Temperature sensitive nanoparticles (E20F) were generated from a construct of three chains of Elastin- Like Polypeptides (ELP) linked to a negatively charged foldon domain. This ELP system was mixed at different ratios with a single linear chain of ELP (H40L) which was deprived of the foldon domain. The mixed system is soluble at room temperature and at a transition temperature will form swollen micelles with the hydrophobic linear chains hidden inside. This system was studied using Depolarized Dynamic Light Scattering (DDLS) and Static Light Scattering (SLS) to model the size, shape, and internal structure of the mixed micelles. The mixed …
Identifying Patterns Of Stress Through Biological Markers, Kristyn Oravec
Identifying Patterns Of Stress Through Biological Markers, Kristyn Oravec
Undergraduate Research Posters 2016
technique, the angle of incidence of the ion beam was 67° from the surface normal,
Bioinformatic Analysis Of The Sodium Hydrogen Exchanger Protein In Plasmodium Yoelii, Jamira Virk, Raghavendra Yadavalli
Bioinformatic Analysis Of The Sodium Hydrogen Exchanger Protein In Plasmodium Yoelii, Jamira Virk, Raghavendra Yadavalli
Undergraduate Research Posters 2016
Since its discovery over 100 years ago, malaria has been the most important parasitic disease in the world. Malaria affects about 300 to 500 million people every year; killing 5 million people every year. The most virulent causative agent in humans is Plasmodium falciparum; it is an important member of the phylum Apicomplexa, which also includes Toxoplasma gondii. These organisms contain specialized, unique structures, including rhoptry organelles. In Plasmodium and Toxoplasma gondii, they assist invasion into the host cell. Analyses have been performed on proteins located in rhoptries in Toxoplasma and Plasmodium. Among the proteins that have been analyzed, the …
Expression Of Recombinant Proteins In Bacteria For Antibody Production, John Sabljic, Anton Denisyuk, Hallie Schmolz, Olivera Prica
Expression Of Recombinant Proteins In Bacteria For Antibody Production, John Sabljic, Anton Denisyuk, Hallie Schmolz, Olivera Prica
Undergraduate Research Posters 2016
The protozoan parasite Trypanosoma brucei causes fatal African trypanosomiasis in humans and nagana in cattle. Transmitted by the tsetse fly, T. brucei proliferates in the bloodstream of its mammalian host and evades the host's immune response by regularly switching its major surface antigen, VSG, which forms a thick coat on its cell membrane. VSGs are exclusively expressed from sub-telomeric regions of the T. brucei genome in a strictly monoallelic fashion. Telomeres, DNA-protein complexes located at chromosome ends, help maintain chromosome stability and integrity. We have also found that telomere proteins are important for regulating VSG expression and switching. We are …
Identification Of Factors That Mediate Strand Exchange During Early Meiosis At Low Double Strand Break Levels, Isaac Kuragayla, Rima Sandhu
Identification Of Factors That Mediate Strand Exchange During Early Meiosis At Low Double Strand Break Levels, Isaac Kuragayla, Rima Sandhu
Undergraduate Research Posters 2016
Genetic recombination is essential in order to create diversity amongst all of the genetic information. Crossovers also contribute to segregation of homologous chromosomes to opposite spindle poles during the first meiotic division. Meiotic strand exchange in Saccharomyces cerevisiae, budding yeast, aims to diversify genetic information in the resulting gametes which in budding yeast are called spores. While Dmc1 and Rad51 are two proteins that are known to play a role in double strand break (DSB) repair, the exact function of Rad51 is still unclear. It is known that Rad51 is responsible for strand exchange in mitosis, but it is still …
Phosphorus Concentrations In The Cuyahoga River Watershed Linked To Anthropogenic Inputs, Christopher Kasden
Phosphorus Concentrations In The Cuyahoga River Watershed Linked To Anthropogenic Inputs, Christopher Kasden
Undergraduate Research Posters 2016
Twenty-four water samples were taken from twelve sites throughout the Cuyahoga watershed from upstream to downstream within two separate occasions. Twelve samples were taken on May 25th, 2016 with no prior precipitation and the conditions were calm, and twelve samples were taken on July14, 2016 when high precipitation had occurred and water conditions were much more diverse. Using the Automated Discrete Analyzer, the concentrations of phosphorus could be analyzed and differentiated between Total Phosphorus and Soluble Reactive Phosphorus. In comparison to the Environmental Protection Agency whose target concentrations for rivers is .05ppm, in both cases of the experiment the hypothesis …