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Full-Text Articles in Life Sciences
Exploring New Chemotherapeutic Strategies Against Brain Cancer, Seol Kim, Anthony J. Berdis
Exploring New Chemotherapeutic Strategies Against Brain Cancer, Seol Kim, Anthony J. Berdis
Undergraduate Research Posters 2013
Approximately 4,000 children in the United States are diagnosed each year with a brain tumor. Brain cancers are the deadliest of all pediatric cancers as they have survival rates of less than 20%. Typical treatments include surgery and radiation therapy. However, chemotherapy is the primary therapeutic option for children, especially against aggressive brain tumors. An important chemotherapeutic agent is temozolomide, an alkylating agent that causes cell death by damaging DNA. In this project, we tested the ability of non-natural nucleosides developed in our lab in order to increase the ability of temozolomide to kill brain cancer cells. Our results show …
Function Of A Novel Checkpoint Protein In The Germ Line, Steven Drellishak, Marina Bykova, G. Valentin Börner
Function Of A Novel Checkpoint Protein In The Germ Line, Steven Drellishak, Marina Bykova, G. Valentin Börner
Undergraduate Research Posters 2013
Successful reproduction of Saccharomyces cerevisiae relies on the organism’s ability to complete the meiotic cell cycle and produce viable gametes. Zip1 is a protein that constitutes the central component of a protein structure that connects homologous chromosomes known as the synaptonemal complex. Zip1 is important for progression through the meiotic cell cycle. The C terminus of the coiled-coil Zip 1 protein is responsible for localization to the axes of the chromosomes. An internal deletion near the C terminus of Zip1, called zip1-c1, yields a stronger meiotic arrest than a mutation where Zip1 is completely deleted. The more efficient meiotic progression …