Life Sciences Commons^™

Increased Diphacinone And Chlorophacinone Metabolism In Previously Exposed Wild Caught Voles, Microtus Californicus, Katherine E. Horak, Steven F. Volker, Christopher M. Campton

USDA Wildlife Services: Staff Publications

Rodents have been noteworthy pests in agricultural areas for decades. Because rodents impact diverse ecosystems, anticoagulant rodenticides have been heavily used throughout the world to control rodent populations. This continued use has led to the development of resistance to anticoagulant rodenticides in some populations of targeted rodents. Although many studies have investigated the genetic and molecular basis of anticoagulant resistance, few have focused on potential changes in metabolic function of resistant animals. In this study, vole (Microtus californicus, Peale) liver microsome preparations were made from unexposed animals living in areas that had never used anticoagulant rodenticides for either crop protection …