Open Access. Powered by Scholars. Published by Universities.®
- Keyword
- File Type
Articles 1 - 4 of 4
Full-Text Articles in Life Sciences
Anti-Inflammatory Protein Of Schistosoma Japonicum Directs The Differentiation Of The Wehi-3b Jcs Cells And Mouse Bone Marrow Cells To Macrophages, Shaomin Hu, Linlin Yang, Zhongdao Wu, Nai Ki Mak, Kwok Nam Leung, Ming Chiu Fung
Anti-Inflammatory Protein Of Schistosoma Japonicum Directs The Differentiation Of The Wehi-3b Jcs Cells And Mouse Bone Marrow Cells To Macrophages, Shaomin Hu, Linlin Yang, Zhongdao Wu, Nai Ki Mak, Kwok Nam Leung, Ming Chiu Fung
Professor MAK, Nai Ki
Sj16 is an anti-inflammatory protein identified from Schistosoma japonicum. Our previous studies showed that recombinant Sj16 (rSj16) could suppress host's inflammatory responses and inhibit macrophage maturation. In the present study, the effects of rSj16 on the differentiation of the murine myeloid leukemia WEHI-3B JCS cell line and on mouse hematopoiesis were investigated. Our data demonstrated that rSj16 expressed and purified from Escherichia coli could suppress the proliferation of the WEHI-3B JCS cells in a time- and concentration-dependent manner, while not affect the viability of the cells. Further studies indicated that rSj16 induced macrophage differentiation of the WEHI-3B JCS cells, and …
Role Of Stat3/5 And Bcl-2/Xl In 2-Methoxyestradiol-Induced Endoreduplication Of Nasopharyngeal Carcinoma Cells, Cm Ting, Ck Wong, Rn Wong, Kw Lo, Aw Lee, Gs Tsao, Ml Lung, N.K. Mak
Role Of Stat3/5 And Bcl-2/Xl In 2-Methoxyestradiol-Induced Endoreduplication Of Nasopharyngeal Carcinoma Cells, Cm Ting, Ck Wong, Rn Wong, Kw Lo, Aw Lee, Gs Tsao, Ml Lung, N.K. Mak
Professor MAK, Nai Ki
2-methoxyestradiol (2ME2), an endogenous metabolite of 17-b-estradiol, has been shown to induce apoptosis and cell cycle arrest in various tumor models. We have previously shown that 2ME2 induced endoreduplication in a welldifferentiated nasopharyngeal carcinoma (NPC) HK-1 and a poorly differentiated C666-1 cell line. In the present study, we studied the survival factors involved in 2ME2-induced endoreduplicating NPC cells. In the HK-1 cells, knockdown of BcL-xL expression by siRNA resulted in the reduction of endoreduplication and an increase in the percentage of apoptosis. Further mechanistic study revealed that 2ME2 enhanced the expression of the phosphorylated form of STAT5 (p-STAT5-Y694), but not …
Targeted Inhibition Of The Egfr Pathways Enhances Zn-Bc-Am Pdt-Induced Apoptosis In Well-Differentiated Nasopharyngeal Carcinoma Cells, Hk Koon, Ps Chan, Rns Wong, Zg Wu, Ml Lung, Ck Chang, N.K. Mak
Targeted Inhibition Of The Egfr Pathways Enhances Zn-Bc-Am Pdt-Induced Apoptosis In Well-Differentiated Nasopharyngeal Carcinoma Cells, Hk Koon, Ps Chan, Rns Wong, Zg Wu, Ml Lung, Ck Chang, N.K. Mak
Professor MAK, Nai Ki
No abstract provided.
Photosensitizers As Novel Compounds In Apoptosis Research, N.K. Mak, M.L. Lung, C.K. Chang, K.N. Leung
Photosensitizers As Novel Compounds In Apoptosis Research, N.K. Mak, M.L. Lung, C.K. Chang, K.N. Leung
Professor MAK, Nai Ki
No abstract provided.