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Cpsf30 At The Interface Of Alternative Polyadenylation And Cellular Signaling In Plants, Manohar Chakrabarti, Arthur G. Hunt
Cpsf30 At The Interface Of Alternative Polyadenylation And Cellular Signaling In Plants, Manohar Chakrabarti, Arthur G. Hunt
Plant and Soil Sciences Faculty Publications
Post-transcriptional processing, involving cleavage of precursor messenger RNA (pre mRNA), and further incorporation of poly(A) tail to the 3' end is a key step in the expression of genetic information. Alternative polyadenylation (APA) serves as an important check point for the regulation of gene expression. Recent studies have shown widespread prevalence of APA in diverse systems. A considerable amount of research has been done in characterizing different subunits of so-called Cleavage and Polyadenylation Specificity Factor (CPSF). In plants, CPSF30, an ortholog of the 30 kD subunit of mammalian CPSF is a key polyadenylation factor. CPSF30 in the model plant Arabidopsis …