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Full-Text Articles in Life Sciences
Mechanism By Which Insulin And Its Mimetics, Selenite And Vanadate, Regulate Glucose-6-Phosphate Dehydrogenase Gene Expression, Sanjay M. Jivarj
Mechanism By Which Insulin And Its Mimetics, Selenite And Vanadate, Regulate Glucose-6-Phosphate Dehydrogenase Gene Expression, Sanjay M. Jivarj
Masters Theses
Glucose-6-phosphate dehydrogenase (G6PDH) is a key enzyme of the pentose phosphate pathway. It controls the carbon flow through this pathway, producing reducing equivalents in the form of NADPH to meet the cellular need for reductive biosynthesis and the maintenance of the cellular redox state. Hepatic expression of G6PDH has been shown to be regulated by hormones, nutrients and some growth factors, however the mechanism by which these factors regulate G6PDH gene expression has not been characterized. Here we investigate the mechanism by which insulin and its mimetics, selenate and vanadate, regulate G6PDH gene expression.
Insulin exerts its tissue specific affect …
Stage-Dependent Expression Of Target-Derived Influences Stimulates Axon Outgrowth In Hirudo Medicinalis, Tina M. Harik
Stage-Dependent Expression Of Target-Derived Influences Stimulates Axon Outgrowth In Hirudo Medicinalis, Tina M. Harik
Masters Theses
Our lab has been investigating the development of neuronal phenotype and circuitry in Hirudo medicinalis. Early in embryogenesis the heart excitor (HE) motor neuron selectively extends multiple arbors into the body wall prior to heart tube (HT) formation. HE contact with HT primordium at later stages of development results in remodeling such that arbors are elaborated on the HT, while those in the body wall are retracted. HT-derived cues are necessary for HE remodeling (Jellies, 1995. Am. Zool. 35:529; Jellies and Kopp, 1995. Invert. Neurosci. 1:145). HT and body wall explants were co-cultured to investigate the possible influences of …
Characterization Of Swinepox Virus Secretory Polypeptides, Takeshi Shimamura
Characterization Of Swinepox Virus Secretory Polypeptides, Takeshi Shimamura
Masters Theses
Swinepox virus (SPV) is the only known member of the genus Suispoxvirus. SPV causes a mild disease in swine characterized by slight fever, and weight loss, associated with lesions restricted to the skin. There have been few studies on SPV. Other poxviruses, such as vaccinia virus, have been well characterized and the biological activities of their secretory polypeptides have been analyzed. This study describes a major SPV secretory polypeptide with an apparent molecular mass of 35kDa. Poxvirus encoded polypeptides secreted during infection are known to exhibit immunomodulatory activities. The 35kDa SPV secretory polypeptide was tested.for its ability to inhibit …